Format

Send to:

Choose Destination

Skor1 SKI family transcriptional corepressor 1 [ Mus musculus (house mouse) ]

Gene ID: 207667, updated on 24-Dec-2019

Summary

Official Symbol
Skor1provided by MGI
Official Full Name
SKI family transcriptional corepressor 1provided by MGI
Primary source
MGI:MGI:2443473
See related
Ensembl:ENSMUSG00000022245
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Corl1; Lbxcor1; AV273001; C230094B15Rik
Expression
Biased expression in CNS E14 (RPKM 2.7), whole brain E14.5 (RPKM 2.5) and 4 other tissues See more
Orthologs

Genomic context

See Skor1 in Genome Data Viewer
Location:
9; 9 B
Exon count:
11
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (63138164..63148961, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (62985971..62996768, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A (Ppia) pseudogene 9_818.1 Neighboring gene predicted gene, 25064 Neighboring gene mitogen-activated protein kinase kinase 5 Neighboring gene predicted gene, 39355 Neighboring gene RIKEN cDNA 2300009A05 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
negative regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
SKI family transcriptional corepressor 1
Names
Lbx1 corepressor 1
fussel-15 homolog
ladybird homeobox 1 homolog corepressor 1
ladybird homeobox corepressor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163755.1NP_001157227.1  SKI family transcriptional corepressor 1 isoform 2

    See identical proteins and their annotated locations for NP_001157227.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC159821, AC160392, BC138063
    Consensus CDS
    CCDS52829.1
    UniProtKB/Swiss-Prot
    Q8BX46
    Related
    ENSMUSP00000113924.1, ENSMUST00000119146.7
    Conserved Domains (3) summary
    smart01046
    Location:152244
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    pfam02437
    Location:47140
    Ski_Sno; SKI/SNO/DAC family
    cl23720
    Location:815913
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  2. NM_001163757.1NP_001157229.1  SKI family transcriptional corepressor 1 isoform 3

    See identical proteins and their annotated locations for NP_001157229.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 5' and 3' coding regions, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC159821, AC160392, AK134840
    UniProtKB/Swiss-Prot
    Q8BX46
    Conserved Domains (3) summary
    smart01046
    Location:152244
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    pfam02437
    Location:47140
    Ski_Sno; SKI/SNO/DAC family
    cl23720
    Location:815880
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  3. NM_001163758.1NP_001157230.1  SKI family transcriptional corepressor 1 isoform 4

    See identical proteins and their annotated locations for NP_001157230.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC159821, AC160392, AK029916
    Consensus CDS
    CCDS52828.1
    UniProtKB/TrEMBL
    D3YX64
    Related
    ENSMUSP00000112312.2, ENSMUST00000116613.8
    Conserved Domains (3) summary
    smart01046
    Location:141233
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    pfam02437
    Location:36129
    Ski_Sno; SKI/SNO/DAC family
    cl23720
    Location:804902
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  4. NM_172446.3NP_766034.2  SKI family transcriptional corepressor 1 isoform 1

    See identical proteins and their annotated locations for NP_766034.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC159821, AK049035
    Consensus CDS
    CCDS23268.1
    UniProtKB/Swiss-Prot
    Q8BX46
    Related
    ENSMUSP00000055037.7, ENSMUST00000055281.7
    Conserved Domains (3) summary
    smart01046
    Location:180272
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    pfam02437
    Location:75168
    Ski_Sno; SKI/SNO/DAC family
    cl23720
    Location:843941
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p6 C57BL/6J

    Range
    63138164..63148961 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510910.4XP_006510973.1  SKI family transcriptional corepressor 1 isoform X1

    See identical proteins and their annotated locations for XP_006510973.1

    UniProtKB/TrEMBL
    D3YX64
    Conserved Domains (3) summary
    smart01046
    Location:141233
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    pfam02437
    Location:36129
    Ski_Sno; SKI/SNO/DAC family
    cl23720
    Location:804902
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  2. XM_006510909.4XP_006510972.1  SKI family transcriptional corepressor 1 isoform X1

    See identical proteins and their annotated locations for XP_006510972.1

    UniProtKB/TrEMBL
    D3YX64
    Conserved Domains (3) summary
    smart01046
    Location:141233
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    pfam02437
    Location:36129
    Ski_Sno; SKI/SNO/DAC family
    cl23720
    Location:804902
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
Support Center