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Wdr37 WD repeat domain 37 [ Mus musculus (house mouse) ]

Gene ID: 207615, updated on 9-Mar-2023

Summary

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Official Symbol
Wdr37provided by MGI
Official Full Name
WD repeat domain 37provided by MGI
Primary source
MGI:MGI:1920393
See related
Ensembl:ENSMUSG00000021147 AllianceGenome:MGI:1920393
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be located in cytoplasm and nucleus. Predicted to be part of preribosome, large subunit precursor. Is expressed in nervous system and neural retina. Human ortholog(s) of this gene implicated in neurooculocardiogenitourinary syndrome. Orthologous to human WDR37 (WD repeat domain 37). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 6.0), whole brain E14.5 (RPKM 5.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Wdr37 in Genome Data Viewer
Location:
13; 13 A1
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (8853002..8922136, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (8802966..8872100, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene basic leucine zipper and W2 domains 1 pseudogene Neighboring gene adenosine deaminase, RNA-specific, B2 Neighboring gene ribosomal protein L10A, pseudogene 2 Neighboring gene isopentenyl-diphosphate delta isomerase Neighboring gene isopentenyl-diphosphate delta isomerase 2 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Calcium flux control by Pacs1-Wdr37 promotes lymphocyte quiescence and lymphoproliferative diseases. Nair-Gill E, et al. EMBO J, 2021 May 3. PMID 33630350, Free PMC Article
  2. WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy. Kannan M, et al. Proc Natl Acad Sci U S A, 2017 Oct 31. PMID 29078390, Free PMC Article
  3. Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen. Liakath-Ali K, et al. Nat Commun, 2014 Apr 11. PMID 24721909, Free PMC Article
  4. Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis. Cirilli M, et al. Biochim Biophys Acta Gen Subj, 2017 Feb. PMID 27746211
  5. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538

See all (31) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Calcium flux control by Pacs1-Wdr37 promotes lymphocyte quiescence and lymphoproliferative diseases.
    Title: Calcium flux control by Pacs1-Wdr37 promotes lymphocyte quiescence and lymphoproliferative diseases.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • mKIAA0982, 6430603N07, 3110035P10Rik, 4933417A01Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within corpus callosum development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lymphocyte homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
WD repeat-containing protein 37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039388.2 → NP_001034477.1  WD repeat-containing protein 37 isoform a

    See identical proteins and their annotated locations for NP_001034477.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC132433, AK036203, BB611667, BY122174
    Consensus CDS
    CCDS26232.1
    UniProtKB/Swiss-Prot
    Q8CBE3, Q8CCL2
    UniProtKB/TrEMBL
    A0A8C6H0P4
    Related
    ENSMUSP00000062174.7, ENSMUST00000054251.13
    Conserved Domains (2) summary
    cd00200
    Location:148 → 486
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:159 → 197
    7WD40; WD40 repeat [structural motif]

  2. NM_001039389.2 → NP_001034478.1  WD repeat-containing protein 37 isoform b

    See identical proteins and their annotated locations for NP_001034478.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several exons, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC124732, AK044740, CJ134699
    Consensus CDS
    CCDS49204.1
    UniProtKB/TrEMBL
    Q05BF4, Q8C8P3
    Related
    ENSMUSP00000135742.2, ENSMUST00000176922.8

  3. NM_172445.3 → NP_766033.1  WD repeat-containing protein 37 isoform a

    See identical proteins and their annotated locations for NP_766033.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC132433, AK036203, CJ134699
    Consensus CDS
    CCDS26232.1
    UniProtKB/Swiss-Prot
    Q8CBE3, Q8CCL2
    UniProtKB/TrEMBL
    A0A8C6H0P4
    Related
    ENSMUSP00000021572.5, ENSMUST00000021572.11
    Conserved Domains (2) summary
    cd00200
    Location:148 → 486
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:159 → 197
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    8853002..8922136 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516470.3 → XP_006516533.1  WD repeat-containing protein 37 isoform X1

    See identical proteins and their annotated locations for XP_006516533.1

    UniProtKB/Swiss-Prot
    Q8CBE3, Q8CCL2
    UniProtKB/TrEMBL
    A0A8C6H0P4
    Conserved Domains (2) summary
    cd00200
    Location:148 → 486
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:159 → 197
    7WD40; WD40 repeat [structural motif]

  2. XM_036157955.1 → XP_036013848.1  WD repeat-containing protein 37 isoform X1

    UniProtKB/Swiss-Prot
    Q8CCL2
    UniProtKB/TrEMBL
    A0A8C6H0P4
    Conserved Domains (2) summary
    cd00200
    Location:148 → 486
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:159 → 197
    7WD40; WD40 repeat [structural motif]

  3. XM_006516469.4 → XP_006516532.1  WD repeat-containing protein 37 isoform X1

    See identical proteins and their annotated locations for XP_006516532.1

    UniProtKB/Swiss-Prot
    Q8CBE3, Q8CCL2
    UniProtKB/TrEMBL
    A0A8C6H0P4
    Conserved Domains (2) summary
    cd00200
    Location:148 → 486
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:159 → 197
    7WD40; WD40 repeat [structural motif]

  4. XM_006516471.5 → XP_006516534.1  WD repeat-containing protein 37 isoform X2

    UniProtKB/TrEMBL
    A0A8C6H2G5
    Conserved Domains (3) summary
    cd00200
    Location:103 → 441
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:114 → 152
    7WD40; WD40 repeat [structural motif]
    pfam05103
    Location:19 → 46
    DivIVA; DivIVA protein

RNA

  1. XR_003950440.2 RNA Sequence

  2. XR_382013.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CBE3.1 GenPept UniProtKB/Swiss-Prot:Q8CBE3

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