Sprr2f small proline-rich protein 2F [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sprr2fprovided by MGI
Official Full Name: small proline-rich protein 2Fprovided by MGI
Primary source: MGI:MGI:1330349
See related: Ensembl:ENSMUSG00000050635 AllianceGenome:MGI:1330349
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Acts upstream of or within response to estradiol. Located in cytoplasm and nucleus. Is expressed in ureteric trunk. [provided by Alliance of Genome Resources, Mar 2025]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 59.5) and ovary adult (RPKM 30.4) See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 3 F1; 3 40.14 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (92272494..92273754)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (92365187..92366442)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sprr2f protects against renal injury by decreasing the level of reactive oxygen species in female mice.
Title: Sprr2f protects against renal injury by decreasing the level of reactive oxygen species in female mice.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

General gene information

Go to the top of the page Help

Markers

NoName (e-PCR)
- UniSTS:495497

BB284336 (e-PCR)
- UniSTS:207530

NoName (e-PCR)
- UniSTS:489168

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in epidermis development	NAS Non-traceable Author Statement more info	PubMed
involved_in keratinization	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte differentiation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to estradiol	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cornified envelope	NAS Non-traceable Author Statement more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: small proline-rich protein 2F

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.