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Camkk2 calcium/calmodulin-dependent protein kinase kinase 2, beta [ Mus musculus (house mouse) ]

Gene ID: 207565, updated on 27-Feb-2024

Summary

Official Symbol
Camkk2provided by MGI
Official Full Name
calcium/calmodulin-dependent protein kinase kinase 2, betaprovided by MGI
Primary source
MGI:MGI:2444812
See related
Ensembl:ENSMUSG00000029471 AllianceGenome:MGI:2444812
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0787; 6330570N16Rik
Summary
Predicted to enable calcium ion binding activity; calmodulin binding activity; and calmodulin-dependent protein kinase activity. Predicted to be involved in CAMKK-AMPK signaling cascade; activation of protein kinase activity; and protein autophosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytosol. Is expressed in nervous system; neural retina; and testis. Orthologous to human CAMKK2 (calcium/calmodulin dependent protein kinase kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 29.2), cerebellum adult (RPKM 25.5) and 26 other tissues See more
Orthologs
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Genomic context

See Camkk2 in Genome Data Viewer
Location:
5 F; 5 62.55 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (122856064..122918295, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (122718380..122779522, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 7 Neighboring gene microRNA 8115 Neighboring gene STARR-seq mESC enhancer starr_14295 Neighboring gene predicted gene 10064 Neighboring gene purinergic receptor P2X, ligand-gated ion channel 4 Neighboring gene STARR-positive B cell enhancer ABC_E3614 Neighboring gene STARR-seq mESC enhancer starr_14298 Neighboring gene anaphase-promoting complex subunit 5 Neighboring gene STARR-positive B cell enhancer ABC_E10348 Neighboring gene STARR-positive B cell enhancer ABC_E1307 Neighboring gene STARR-positive B cell enhancer ABC_E2762 Neighboring gene predicted gene, 33044

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (7)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in CAMKK-AMPK signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in CAMKK-AMPK signaling cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase kinase 2
Names
caM-KK 2
caM-KK beta
caM-kinase kinase 2
caM-kinase kinase beta
caMKK 2
caMKK beta
calcium/calmodulin-dependent protein kinase kinase beta
NP_001186605.1
NP_663333.1
XP_006530293.1
XP_006530294.1
XP_006530295.1
XP_006530296.1
XP_006530297.1
XP_006530298.1
XP_006530299.1
XP_017176252.1
XP_030110166.1
XP_030110167.1
XP_036020841.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199676.1NP_001186605.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_001186605.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AC115728, AK031399, AK032070, AK042935, AW045178
    Consensus CDS
    CCDS80395.1
    UniProtKB/Swiss-Prot
    Q80TS0, Q8BXM8, Q8C078, Q8C0G3, Q8CH42, Q8QZT7
    Related
    ENSMUSP00000107297.5, ENSMUST00000111668.8
    Conserved Domains (1) summary
    cl21453
    Location:162447
    PKc_like; Protein Kinases, catalytic domain
  2. NM_145358.2NP_663333.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform 2

    See identical proteins and their annotated locations for NP_663333.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region which shifts the reading frame, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AC115728, AK031399, AK042935, AW045178, CK625345
    Consensus CDS
    CCDS19655.1
    UniProtKB/Swiss-Prot
    Q8C078
    Related
    ENSMUSP00000143732.2, ENSMUST00000200109.5
    Conserved Domains (2) summary
    smart00220
    Location:165446
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:162447
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    122856064..122918295 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530234.5XP_006530297.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X5

    Conserved Domains (1) summary
    cl21453
    Location:162447
    PKc_like; Protein Kinases, catalytic domain
  2. XM_030254306.2XP_030110166.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:162442
    PKc_like; Protein Kinases, catalytic domain
  3. XM_006530235.5XP_006530298.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:162442
    PKc_like; Protein Kinases, catalytic domain
  4. XM_006530233.5XP_006530296.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:162442
    PKc_like; Protein Kinases, catalytic domain
  5. XM_017320763.3XP_017176252.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X2

    UniProtKB/Swiss-Prot
    Q80TS0, Q8BXM8, Q8C078, Q8C0G3, Q8CH42, Q8QZT7
    Conserved Domains (1) summary
    cl21453
    Location:162447
    PKc_like; Protein Kinases, catalytic domain
  6. XM_030254307.1XP_030110167.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X9

    Conserved Domains (1) summary
    cl21453
    Location:1255
    PKc_like; Protein Kinases, catalytic domain
  7. XM_036164948.1XP_036020841.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X10

    Conserved Domains (1) summary
    cl21453
    Location:1255
    PKc_like; Protein Kinases, catalytic domain
  8. XM_006530230.5XP_006530293.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X1

    See identical proteins and their annotated locations for XP_006530293.1

    UniProtKB/Swiss-Prot
    Q8C078
    Conserved Domains (1) summary
    cl21453
    Location:162447
    PKc_like; Protein Kinases, catalytic domain
  9. XM_006530231.5XP_006530294.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X1

    See identical proteins and their annotated locations for XP_006530294.1

    UniProtKB/Swiss-Prot
    Q8C078
    Conserved Domains (1) summary
    cl21453
    Location:162447
    PKc_like; Protein Kinases, catalytic domain
  10. XM_006530236.5XP_006530299.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X8

    UniProtKB/TrEMBL
    A0A0G2JET2
    Related
    ENSMUSP00000142896.2, ENSMUST00000198029.5
    Conserved Domains (1) summary
    cl21453
    Location:1255
    PKc_like; Protein Kinases, catalytic domain
  11. XM_006530232.5XP_006530295.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:162442
    PKc_like; Protein Kinases, catalytic domain