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Spta1 spectrin alpha, erythrocytic 1 [ Mus musculus (house mouse) ]

Gene ID: 20739, updated on 12-Aug-2019

Summary

Official Symbol
Spta1provided by MGI
Official Full Name
spectrin alpha, erythrocytic 1provided by MGI
Primary source
MGI:MGI:98385
See related
Ensembl:ENSMUSG00000026532
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ha; ihj; sph; nmf4; Spna1; Spna-1; AF093576; AI451697
Expression
Biased expression in liver E14 (RPKM 25.0), liver E14.5 (RPKM 21.2) and 5 other tissues See more
Orthologs

Genomic context

See Spta1 in Genome Data Viewer
Location:
1 H3; 1 80.97 cM
Exon count:
53
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (174172739..174248449)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (176102907..176178580)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene olfactory receptor 421, pseudogene 1 Neighboring gene olfactory receptor 420 Neighboring gene predicted gene, 36196 Neighboring gene olfactory receptor 419 Neighboring gene mucosal pentraxin 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin filament capping IEA
Inferred from Electronic Annotation
more info
 
hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
lymphocyte homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
porphyrin-containing compound biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein binding IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
axon ISO
Inferred from Sequence Orthology
more info
 
cortical cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cuticular plate IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
spectrin IMP
Inferred from Mutant Phenotype
more info
PubMed 
spectrin TAS
Traceable Author Statement
more info
PubMed 
spectrin-associated cytoskeleton IMP
Inferred from Mutant Phenotype
more info
PubMed 
spectrin-associated cytoskeleton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
spectrin alpha chain, erythrocytic 1
Names
alpha-spectrin 1, erythroid
erythroid alpha-spectrin
hemolytic anemia
neuroscience mutagenesis facility, 4
spectrin alpha 1
spectrin alpha chain, erythrocyte
spherocytosis

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011465.4NP_035595.2  spectrin alpha chain, erythrocytic 1

    See identical proteins and their annotated locations for NP_035595.2

    Status: VALIDATED

    Source sequence(s)
    AF093576, AK143823, BY005246
    Consensus CDS
    CCDS35795.1
    UniProtKB/Swiss-Prot
    P08032
    Related
    ENSMUSP00000027817.7, ENSMUST00000027817.7
    Conserved Domains (5) summary
    cd00176
    Location:16061817
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:685783
    Spectrin; Spectrin repeat
    pfam08726
    Location:23462414
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cl08302
    Location:22712339
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl17036
    Location:9801031
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p6 C57BL/6J

    Range
    174172739..174248449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_373600.4 RNA Sequence

  2. XR_001783648.2 RNA Sequence

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