U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fchsd2 FCH and double SH3 domains 2 [ Mus musculus (house mouse) ]

Gene ID: 207278, updated on 26-Sep-2022

Summary

Go to the top of the page Help
Official Symbol
Fchsd2provided by MGI
Official Full Name
FCH and double SH3 domains 2provided by MGI
Primary source
MGI:MGI:2448475
See related
Ensembl:ENSMUSG00000030691 AllianceGenome:MGI:2448475
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NWK1; Sh3md3; mKIAA0769
Summary
Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in multi-organism membrane organization and positive regulation of actin filament polymerization. Located in stereocilium shaft. Is expressed in tail dorsal root ganglion and trigeminal ganglion. Orthologous to human FCHSD2 (FCH and double SH3 domains 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 15.4), whole brain E14.5 (RPKM 12.6) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Fchsd2 in Genome Data Viewer
Location:
7; 7 E2
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100757836..100933613)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101108499..101284405)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2Y, G-protein coupled 2 Neighboring gene ribosomal protein S29 pseudogene Neighboring gene ribosomal protein L27 pseudogene Neighboring gene predicted gene, 47324 Neighboring gene uncharacterized LOC115486538 Neighboring gene predicted gene, 50587 Neighboring gene autophagy related 16-like 2 (S. cerevisiae) Neighboring gene START domain containing 10 Neighboring gene predicted gene 20476

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification and characterization of human FCHSD1 and FCHSD2 genes in silico. Katoh M, et al. Int J Mol Med, 2004 May. PMID 15067381
  2. Formation of membrane ridges and scallops by the F-BAR protein Nervous Wreck. Becalska AN, et al. Mol Biol Cell, 2013 Aug. PMID 23761074, Free PMC Article
  3. FCHSD1 and FCHSD2 are expressed in hair cell stereocilia and cuticular plate and regulate actin polymerization in vitro. Cao H, et al. PLoS One, 2013. PMID 23437151, Free PMC Article
  4. Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice. Lenihan JA, et al. Mol Neurobiol, 2017 Dec. PMID 27889896
  5. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article

See all (19) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our results suggest that FCHSD1 and FCHSD2 could modulate F-actin assembly or maintenance in hair cell stereocilia and cuticular plate.
    Title: FCHSD1 and FCHSD2 are expressed in hair cell stereocilia and cuticular plate and regulate actin polymerization in vitro.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuromuscular synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuromuscular junction IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in stereocilium shaft IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
F-BAR and double SH3 domains protein 2
Names
FCH and double SH3 domains protein 2
SH3 multiple domains 3
SH3 multiple domains protein 3
protein nervous wreck 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146010.1 → NP_001139482.1  F-BAR and double SH3 domains protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001139482.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the mid coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AK140322, AK141949, BC060647
    Consensus CDS
    CCDS52328.1
    UniProtKB/Swiss-Prot
    Q3USJ8, Q80TS2
    UniProtKB/TrEMBL
    A0A6P5PVR8, A0A8C6I908
    Related
    ENSMUSP00000095850.4, ENSMUST00000098250.10
    Conserved Domains (3) summary
    cd07677
    Location:16 → 275
    F-BAR_FCHSD2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH and double SH3 domains 2 (FCHSD2)
    cd11761
    Location:471 → 527
    SH3_FCHSD_1; First Src Homology 3 domain of FCH and double SH3 domains proteins
    cd11894
    Location:571 → 626
    SH3_FCHSD2_2; Second Src Homology 3 domain of FCH and double SH3 domains protein 2

  2. NM_199012.2 → NP_950177.2  F-BAR and double SH3 domains protein 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK141949, BC060647
    Consensus CDS
    CCDS52327.1
    UniProtKB/Swiss-Prot
    Q3USJ8
    UniProtKB/TrEMBL
    A0A6P5Q7L5, A0A8C6IAG0
    Related
    ENSMUSP00000032931.8, ENSMUST00000032931.9
    Conserved Domains (3) summary
    cd07677
    Location:16 → 275
    F-BAR_FCHSD2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH and double SH3 domains 2 (FCHSD2)
    cd11761
    Location:495 → 551
    SH3_FCHSD_1; First Src Homology 3 domain of FCH and double SH3 domains proteins
    cd11894
    Location:595 → 650
    SH3_FCHSD2_2; Second Src Homology 3 domain of FCH and double SH3 domains protein 2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    100757836..100933613
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507518.4 → XP_006507581.1  F-BAR and double SH3 domains protein 2 isoform X3

    Conserved Domains (3) summary
    cd11761
    Location:335 → 391
    SH3_FCHSD_1; First Src Homology 3 domain of FCH and double SH3 domains proteins
    cd11894
    Location:435 → 490
    SH3_FCHSD2_2; Second Src Homology 3 domain of FCH and double SH3 domains protein 2
    cl12013
    Location:1 → 115
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. XM_036152850.1 → XP_036008743.1  F-BAR and double SH3 domains protein 2 isoform X4

    Conserved Domains (3) summary
    cd11761
    Location:311 → 367
    SH3_FCHSD_1; First Src Homology 3 domain of FCH and double SH3 domains proteins
    cd11894
    Location:411 → 466
    SH3_FCHSD2_2; Second Src Homology 3 domain of FCH and double SH3 domains protein 2
    cl12013
    Location:1 → 115
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. XM_030242304.2 → XP_030098164.1  F-BAR and double SH3 domains protein 2 isoform X2

    Conserved Domains (3) summary
    cd11761
    Location:389 → 445
    SH3_FCHSD_1; First Src Homology 3 domain of FCH and double SH3 domains proteins
    cd11894
    Location:489 → 544
    SH3_FCHSD2_2; Second Src Homology 3 domain of FCH and double SH3 domains protein 2
    cl12013
    Location:1 → 193
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  4. XM_006507517.4 → XP_006507580.1  F-BAR and double SH3 domains protein 2 isoform X1

    Conserved Domains (3) summary
    cd11761
    Location:413 → 469
    SH3_FCHSD_1; First Src Homology 3 domain of FCH and double SH3 domains proteins
    cd11894
    Location:513 → 568
    SH3_FCHSD2_2; Second Src Homology 3 domain of FCH and double SH3 domains protein 2
    cl12013
    Location:1 → 193
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3USJ8.2 GenPept UniProtKB/Swiss-Prot:Q3USJ8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous