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Serpinb5 serine (or cysteine) peptidase inhibitor, clade B, member 5 [ Mus musculus (house mouse) ]

Gene ID: 20724, updated on 11-Sep-2018

Summary

Official Symbol
Serpinb5provided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade B, member 5provided by MGI
Primary source
MGI:MGI:109579
See related
Ensembl:ENSMUSG00000067006 Vega:OTTMUSG00000020990
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PI-5; Spi7; Maspin; AI462524; AI646751; ovalbumin; 1110036M19Rik
Expression
Biased expression in bladder adult (RPKM 5.5), colon adult (RPKM 2.3) and 7 other tissues See more
Orthologs

Genomic context

See Serpinb5 in Genome Data Viewer
Location:
1; 1 E2.1
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (106861180..106883348)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (108757757..108779925)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene 3-ketodihydrosphingosine reductase Neighboring gene vacuolar protein sorting 4B Neighboring gene POU domain, class 2, transcription factor 3, related sequence 1 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 12

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • p53 signaling, organism-specific biosystem (from WikiPathways)
    p53 signaling, organism-specific biosystemhttp://www.kegg.jp/ (mmu04115) p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcription...
  • p53 signaling pathway, organism-specific biosystem (from KEGG)
    p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
  • p53 signaling pathway, conserved biosystem (from KEGG)
    p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
morphogenesis of an epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prostate gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serpin B5
Names
peptidase inhibitor 5
protease inhibitor 5
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5
serine (or cysteine) proteinase inhibitor, clade B, member 5
serine protease inhibitor 7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360853.1NP_001347782.1  serpin B5 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC025047, AC163626, AK136532, U54705
    Conserved Domains (1) summary
    cd02057
    Location:4375
    maspin_like; Maspin (mammary serine proteinase inhibitor), a member of the serpin superfamily, with a multitude of effects on cells and tissues at an assortment of developmental stages. Maspin has tumor suppressing activity against breast and prostate cancer. In ...
  2. NM_001360854.1NP_001347783.1  serpin B5 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC025047, AC163626
    Conserved Domains (1) summary
    cl00137
    Location:1204
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
  3. NM_009257.4NP_033283.1  serpin B5 isoform a

    See identical proteins and their annotated locations for NP_033283.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC025047, AC163626, AK136532
    Consensus CDS
    CCDS35684.1
    UniProtKB/Swiss-Prot
    P70124
    Related
    ENSMUSP00000083908.6, OTTMUSP00000023027, ENSMUST00000086701.12
    Conserved Domains (1) summary
    cd02057
    Location:4375
    maspin_like; Maspin (mammary serine proteinase inhibitor), a member of the serpin superfamily, with a multitude of effects on cells and tissues at an assortment of developmental stages. Maspin has tumor suppressing activity against breast and prostate cancer. In ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

    Range
    106861180..106883348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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