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Larp4 La ribonucleoprotein 4 [ Mus musculus (house mouse) ]

Gene ID: 207214, updated on 5-Jan-2023

Summary

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Official Symbol
Larp4provided by MGI
Official Full Name
La ribonucleoprotein 4provided by MGI
Primary source
MGI:MGI:2443114
See related
Ensembl:ENSMUSG00000023025 AllianceGenome:MGI:2443114
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DXErtd793; DXErtd793e
Summary
Predicted to enable mRNA 3'-UTR binding activity and poly(A) binding activity. Predicted to be involved in cytoskeleton organization; positive regulation of translation; and regulation of cell morphogenesis. Predicted to act upstream of or within translation. Predicted to be located in cytoplasm. Predicted to be part of cytosolic small ribosomal subunit and polysome. Predicted to be active in cytoplasmic stress granule and cytosol. Orthologous to human LARP4 (La ribonucleoprotein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 11.6), CNS E11.5 (RPKM 5.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Larp4 in Genome Data Viewer
Location:
15; 15 F1
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99867946..99914239)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99970065..100016358)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700121M21 gene Neighboring gene ribosomal protein S10 pseudogene Neighboring gene family with sequence similarity 186, member A Neighboring gene predicted gene, 21917 Neighboring gene RIKEN cDNA 2310068J16 gene Neighboring gene disco interacting protein 2 homolog B Neighboring gene activating transcription factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LARP4 mRNA codon-tRNA match contributes to LARP4 activity for ribosomal protein mRNA poly(A) tail length protection. Mattijssen S, et al. Elife, 2017 Sep 12. PMID 28895529, Free PMC Article
  2. Transcriptome-wide stability analysis uncovers LARP4-mediated NFκB1 mRNA stabilization during T cell activation. Tian Y, et al. Nucleic Acids Res, 2020 Sep 4. PMID 32735645, Free PMC Article
  3. LARP4 Is Regulated by Tumor Necrosis Factor Alpha in a Tristetraprolin-Dependent Manner. Mattijssen S, et al. Mol Cell Biol, 2016 Feb 15. PMID 26644407, Free PMC Article
  4. TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability. Venuto S, et al. Cancer Lett, 2020 Mar 31. PMID 31904480
  5. Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network. Cassar PA, et al. EMBO Rep, 2015 Oct. PMID 26265008, Free PMC Article

See all (29) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transcriptome-wide stability analysis uncovers LARP4-mediated NFkappaB1 mRNA stabilization during T cell activation.
    Title: Transcriptome-wide stability analysis uncovers LARP4-mediated NFκB1 mRNA stabilization during T cell activation.
  2. Mouse LARP4 is regulated by TNF-alpha in a TTP-dependent manner.
    Title: LARP4 Is Regulated by Tumor Necrosis Factor Alpha in a Tristetraprolin-Dependent Manner.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • C530046N12, D330037H05Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in post-transcriptional regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
colocalizes_with cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of polysome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
la-related protein 4
Names
La ribonucleoprotein domain family, member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024526.2 → NP_001019697.2  la-related protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001019697.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (1).
    Source sequence(s)
    AC133868, AK049756, AK139909, BP757308, CJ080411
    Consensus CDS
    CCDS37208.1
    UniProtKB/Swiss-Prot
    Q8BWW4
    UniProtKB/TrEMBL
    G3X9Q6, Q3UT02
    Related
    ENSMUSP00000097780.3, ENSMUST00000100206.4
    Conserved Domains (2) summary
    cd08035
    Location:116 → 190
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:195 → 271
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

  2. NM_001080948.2 → NP_001074417.1  la-related protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5'-terminal exon, initiates translation at an alternate start codon, and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AI853685, AK052358, AK139636, AK139909, AK141743, BE951991, CJ083603
    Consensus CDS
    CCDS49730.1
    UniProtKB/Swiss-Prot
    Q8BWW4
    UniProtKB/TrEMBL
    E9Q066, Q3UT02
    Related
    ENSMUSP00000086964.6, ENSMUST00000057632.16
    Conserved Domains (2) summary
    cd08035
    Location:115 → 189
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:194 → 270
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

  3. NM_001284521.1 → NP_001271450.1  la-related protein 4 isoform 3

    See identical proteins and their annotated locations for NP_001271450.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AI853685, AK052358, AK139636, AK139909, AK141743, BE951991, CJ080411
    Consensus CDS
    CCDS88842.1
    UniProtKB/Swiss-Prot
    Q8BWW4
    UniProtKB/TrEMBL
    A0A2R8VKL5, Q3UT02
    Related
    ENSMUSP00000155661.2, ENSMUST00000231160.2
    Conserved Domains (3) summary
    cd08035
    Location:57 → 131
    LARP_4; La RNA-binding domain of La-related protein 4
    PHA03247
    Location:260 → 657
    PHA03247; large tegument protein UL36; Provisional
    cd12707
    Location:136 → 212
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

  4. NM_001284522.1 → NP_001271451.1  la-related protein 4 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5'-terminal exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AI853685, AK052358, AK139636, AK139909, AK141743, BE951991, CJ083603
    UniProtKB/Swiss-Prot
    Q8BWW4
    UniProtKB/TrEMBL
    Q3UT02
    Conserved Domains (2) summary
    cd08035
    Location:114 → 188
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:193 → 269
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

  5. NM_001284523.1 → NP_001271452.1  la-related protein 4 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (5) is longer, compared to isoform 1.
    Source sequence(s)
    AI853685, AK052358, AK139636, AK139909, AK141743, BE951991, CJ080411
    UniProtKB/Swiss-Prot
    Q8BWW4
    UniProtKB/TrEMBL
    Q3UT02
    Related
    ENSMUSP00000155601.2, ENSMUST00000230956.2
    Conserved Domains (2) summary
    cd08035
    Location:117 → 191
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:196 → 272
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    99867946..99914239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520675.1 → XP_006520738.1  la-related protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006520738.1

    UniProtKB/TrEMBL
    A0A2R8VKL5
    Conserved Domains (3) summary
    cd08035
    Location:57 → 131
    LARP_4; La RNA-binding domain of La-related protein 4
    PHA03247
    Location:260 → 657
    PHA03247; large tegument protein UL36; Provisional
    cd12707
    Location:136 → 212
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

  2. XM_017316524.1 → XP_017172013.1  la-related protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A2R8VKL5
    Conserved Domains (3) summary
    cd08035
    Location:57 → 131
    LARP_4; La RNA-binding domain of La-related protein 4
    PHA03247
    Location:260 → 657
    PHA03247; large tegument protein UL36; Provisional
    cd12707
    Location:136 → 212
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BWW4.2 GenPept UniProtKB/Swiss-Prot:Q8BWW4

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