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Serpinb6a serine (or cysteine) peptidase inhibitor, clade B, member 6a [ Mus musculus (house mouse) ]

Gene ID: 20719, updated on 31-Jan-2019

Summary

Official Symbol
Serpinb6aprovided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade B, member 6aprovided by MGI
Primary source
MGI:MGI:103123
See related
Ensembl:ENSMUSG00000060147
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PI-6; Spi3; Serpinb6; ovalbumin; 4930482L21Rik; D330015H01Rik
Expression
Ubiquitous expression in large intestine adult (RPKM 75.9), bladder adult (RPKM 55.9) and 27 other tissues See more

Genomic context

See Serpinb6a in Genome Data Viewer
Location:
13 A3.3; 13 14.0 cM
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (33917918..34002794, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (34009787..34094618, complement)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 6e Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 6c Neighboring gene RIKEN cDNA 1110046J04 gene Neighboring gene N-ribosyldihydronicotinamide quinone reductase 2 Neighboring gene receptor (TNFRSF)-interacting serine-threonine kinase 1 Neighboring gene biphenyl hydrolase-like (serine hydrolase, breast epithelial mucin-associated antigen) Neighboring gene tubulin, beta 2A class IIA

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • Amoebiasis, organism-specific biosystem (from KEGG)
    Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • Amoebiasis, conserved biosystem (from KEGG)
    Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
protease binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
serine-type endopeptidase inhibitor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cellular response to osmotic stress ISO
Inferred from Sequence Orthology
more info
 
gonad development NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endopeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
sensory perception of sound ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
collagen-containing extracellular matrix HDA PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine protease inhibitor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serpin B6
Names
placental thrombin inhibitor
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6
serine (or cysteine) proteinase inhibitor, clade B, member 6a
serine protease inhibitor 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164117.1NP_001157589.1  serpin B6 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AL450406
    Consensus CDS
    CCDS49228.1
    UniProtKB/TrEMBL
    F8WIV2
    Related
    ENSMUSP00000017188.7, ENSMUST00000017188.13
    Conserved Domains (1) summary
    cl00137
    Location:25399
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
  2. NM_001164118.1NP_001157590.1  serpin B6 isoform b

    See identical proteins and their annotated locations for NP_001157590.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream, in-frame start site, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3 and 4 encode the same isoform.
    Source sequence(s)
    AL450406
    Consensus CDS
    CCDS26441.1
    UniProtKB/Swiss-Prot
    Q60854
    UniProtKB/TrEMBL
    Q4FJQ6
    Related
    ENSMUSP00000131115.1, ENSMUST00000167163.7
    Conserved Domains (1) summary
    cl00137
    Location:4378
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
  3. NM_001243192.1NP_001230121.1  serpin B6 isoform b

    See identical proteins and their annotated locations for NP_001230121.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses a downstream, in-frame start site, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3 and 4 encode the same isoform.
    Source sequence(s)
    AC161117, AL450406, CF732441
    Consensus CDS
    CCDS26441.1
    UniProtKB/Swiss-Prot
    Q60854
    UniProtKB/TrEMBL
    Q4FJQ6
    Related
    ENSMUSP00000075848.7, ENSMUST00000076532.13
    Conserved Domains (1) summary
    cl00137
    Location:4378
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
  4. NM_009254.3NP_033280.1  serpin B6 isoform b

    See identical proteins and their annotated locations for NP_033280.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream, in-frame start site, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3 and 4 encode the same isoform.
    Source sequence(s)
    AL450406
    Consensus CDS
    CCDS26441.1
    UniProtKB/Swiss-Prot
    Q60854
    UniProtKB/TrEMBL
    Q4FJQ6
    Related
    ENSMUSP00000041016.10, ENSMUST00000043552.16
    Conserved Domains (1) summary
    cl00137
    Location:4378
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

    Range
    33917918..34002794 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244299.1XP_011242601.1  serpin B6 isoform X1

    See identical proteins and their annotated locations for XP_011242601.1

    UniProtKB/Swiss-Prot
    Q60854
    UniProtKB/TrEMBL
    Q4FJQ6
    Conserved Domains (1) summary
    cl00137
    Location:4378
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
  2. XM_011244301.1XP_011242603.1  serpin B6 isoform X1

    See identical proteins and their annotated locations for XP_011242603.1

    UniProtKB/Swiss-Prot
    Q60854
    UniProtKB/TrEMBL
    Q4FJQ6
    Conserved Domains (1) summary
    cl00137
    Location:4378
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
  3. XM_006516623.1XP_006516686.1  serpin B6 isoform X1

    See identical proteins and their annotated locations for XP_006516686.1

    UniProtKB/Swiss-Prot
    Q60854
    UniProtKB/TrEMBL
    Q4FJQ6
    Conserved Domains (1) summary
    cl00137
    Location:4378
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
  4. XM_011244300.2XP_011242602.1  serpin B6 isoform X1

    See identical proteins and their annotated locations for XP_011242602.1

    UniProtKB/Swiss-Prot
    Q60854
    UniProtKB/TrEMBL
    Q4FJQ6
    Conserved Domains (1) summary
    cl00137
    Location:4378
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
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