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Ggt7 gamma-glutamyltransferase 7 [ Mus musculus (house mouse) ]

Gene ID: 207182, updated on 5-Feb-2023

Summary

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Official Symbol
Ggt7provided by MGI
Official Full Name
gamma-glutamyltransferase 7provided by MGI
Primary source
MGI:MGI:1913385
See related
Ensembl:ENSMUSG00000027603 AllianceGenome:MGI:1913385
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ggtl3; 1110017C11Rik; 6330563L03Rik
Summary
Predicted to enable glutathione hydrolase activity and peptidyltransferase activity. Predicted to be involved in several processes, including glutathione catabolic process; response to estradiol; and response to tumor necrosis factor. Predicted to act upstream of or within glutathione biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including glans of male genital tubercle; nervous system; and sensory organ. Orthologous to human GGT7 (gamma-glutamyltransferase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 36.7), cortex adult (RPKM 34.9) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Ggt7 in Genome Data Viewer
Location:
2; 2 H1
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155332299..155356921, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (155490379..155514891, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 6 Neighboring gene carnitine deficiency-associated gene expressed in ventricle 3 pseudogene Neighboring gene cytochrome c, somatic pseudogene Neighboring gene acyl-CoA synthetase short-chain family member 2 Neighboring gene acyl-CoA synthetase short-chain family member 2, opposite strand Neighboring gene glutathione synthase, opposite strand 2 Neighboring gene glutathione synthetase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors. Clotman F, et al. Genes Dev, 2005 Aug 15. PMID 16103213, Free PMC Article
  2. High-throughput sequence identification of gene coding variants within alcohol-related QTLs. Ehringer MA, et al. Mamm Genome, 2001 Aug. PMID 11471062
  3. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
  4. Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells. Zhang M, et al. Mol Cell Proteomics, 2014 Nov. PMID 25044020, Free PMC Article
  5. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873

See all (21) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC12004

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hypoglycin A gamma-glutamyl transpeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables leukotriene C4 gamma-glutamyl transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within glutathione biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glutathione catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in negative regulation of response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glutathione hydrolase 7
Names
GGT 7
gamma-glutamyltransferase-like 3
gamma-glutamyltranspeptidase 7
mFLJ00311 protein
NP_001349827.1
NP_001349829.1
NP_659035.2
XP_006499123.1
XP_030104806.1
XP_030104809.1
XP_030104811.1
XP_030104813.1
XP_030104814.1
XP_030104815.1
XP_036015867.1
XP_036015873.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362898.1 → NP_001349827.1  glutathione hydrolase 7 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL844852
    Conserved Domains (1) summary
    pfam01019
    Location:155 → 658
    G_glu_transpept; Gamma-glutamyltranspeptidase

  2. NM_001362900.1 → NP_001349829.1  glutathione hydrolase 7 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate splice junctions compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL844852
    UniProtKB/TrEMBL
    A0A6P7Q7S5
    Conserved Domains (1) summary
    cl19223
    Location:1 → 421
    G_glu_transpept; Gamma-glutamyltranspeptidase

  3. NM_144786.2 → NP_659035.2  glutathione hydrolase 7 isoform 2

    See identical proteins and their annotated locations for NP_659035.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK032051, AK177521, BY127251
    Consensus CDS
    CCDS16949.1
    UniProtKB/Swiss-Prot
    Q91V91, Q99JP7
    Related
    ENSMUSP00000029131.5, ENSMUST00000029131.11
    Conserved Domains (1) summary
    pfam01019
    Location:155 → 654
    G_glu_transpept; Gamma-glutamyltranspeptidase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    155332299..155356921 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248955.2 → XP_030104815.1  glutathione hydrolase 7 isoform X6

    Conserved Domains (1) summary
    cl19223
    Location:155 → 607
    G_glu_transpept; Gamma-glutamyltranspeptidase

  2. XM_006499060.3 → XP_006499123.1  glutathione hydrolase 7 isoform X1

    Conserved Domains (1) summary
    cl19223
    Location:155 → 642
    G_glu_transpept; Gamma-glutamyltranspeptidase

  3. XM_030248949.2 → XP_030104809.1  glutathione hydrolase 7 isoform X4

    Conserved Domains (1) summary
    cl19223
    Location:38 → 443
    G_glu_transpept; Gamma-glutamyltranspeptidase

  4. XM_030248951.2 → XP_030104811.1  glutathione hydrolase 7 isoform X4

    Conserved Domains (1) summary
    cl19223
    Location:38 → 443
    G_glu_transpept; Gamma-glutamyltranspeptidase

  5. XM_030248953.2 → XP_030104813.1  glutathione hydrolase 7 isoform X4

    Conserved Domains (1) summary
    cl19223
    Location:38 → 443
    G_glu_transpept; Gamma-glutamyltranspeptidase

  6. XM_030248946.1 → XP_030104806.1  glutathione hydrolase 7 isoform X3

    Conserved Domains (1) summary
    pfam01019
    Location:1 → 464
    G_glu_transpept; Gamma-glutamyltranspeptidase

  7. XM_036159974.1 → XP_036015867.1  glutathione hydrolase 7 isoform X2

    Conserved Domains (1) summary
    pfam01019
    Location:1 → 470
    G_glu_transpept; Gamma-glutamyltranspeptidase

  8. XM_030248954.2 → XP_030104814.1  glutathione hydrolase 7 isoform X4

    Conserved Domains (1) summary
    cl19223
    Location:38 → 443
    G_glu_transpept; Gamma-glutamyltranspeptidase

  9. XM_036159980.1 → XP_036015873.1  glutathione hydrolase 7 isoform X5

    UniProtKB/TrEMBL
    A0A6P7Q7S5
    Conserved Domains (1) summary
    cl19223
    Location:1 → 421
    G_glu_transpept; Gamma-glutamyltranspeptidase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99JP7.2 GenPept UniProtKB/Swiss-Prot:Q99JP7

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