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Rin1 Ras and Rab interactor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 207119, updated on 13-Aug-2019

Summary

Official Symbol
Rin1provided by RGD
Official Full Name
Ras and Rab interactor 1provided by RGD
Primary source
RGD:620006
See related
Ensembl:ENSRNOG00000050223
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
may act as a regulator of Ras-mediated signal transduction [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 36.9), Lung (RPKM 30.2) and 8 other tissues See more

Genomic context

See Rin1 in Genome Data Viewer
Location:
1q43
Exon count:
9
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (220335036..220342319)
106 current Rn_Celera (GCF_000002265.2) 1 AC_000069.1 (199895635..199900283)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (227359504..227364152)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene beta-1,4-glucuronyltransferase 1 Neighboring gene BRMS1, transcriptional repressor and anoikis regulator Neighboring gene uncharacterized LOC103691276 Neighboring gene uncharacterized LOC102554272 Neighboring gene CD248 molecule

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
Ras GTPase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
associative learning ISO
Inferred from Sequence Orthology
more info
PubMed 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
memory ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
ras and Rab interactor 1
Names
ras inhibitor
ras interaction/interference protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139038.1NP_620607.1  ras and Rab interactor 1

    See identical proteins and their annotated locations for NP_620607.1

    Status: PROVISIONAL

    Source sequence(s)
    U80076
    UniProtKB/Swiss-Prot
    P97680
    Related
    ENSRNOP00000066064.1, ENSRNOT00000072261.2
    Conserved Domains (3) summary
    smart00167
    Location:513631
    VPS9; Domain present in VPS9
    cd10393
    Location:81181
    SH2_RIN1; Src homology 2 (SH2) domain found in Ras and Rab interactor 1 (RIN1)-like proteins
    cl00155
    Location:651728
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    220335036..220342319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008760195.1XP_008758417.1  ras and Rab interactor 1 isoform X1

    See identical proteins and their annotated locations for XP_008758417.1

    Conserved Domains (3) summary
    smart00167
    Location:561679
    VPS9; Domain present in VPS9
    cd10393
    Location:129229
    SH2_RIN1; Src homology 2 (SH2) domain found in Ras and Rab interactor 1 (RIN1)-like proteins
    cl00155
    Location:699776
    UBQ; Ubiquitin-like proteins

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    199895635..199900283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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