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Serpina1a serine (or cysteine) peptidase inhibitor, clade A, member 1A [ Mus musculus (house mouse) ]

Gene ID: 20700, updated on 9-Oct-2022

Summary

Official Symbol
Serpina1aprovided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade A, member 1Aprovided by MGI
Primary source
MGI:MGI:891971
See related
Ensembl:ENSMUSG00000066366 AllianceGenome:MGI:891971
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PI1; Aat2; Dom1; Aat-2; Spi1-1; Spi1-3
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within protein N-linked glycosylation; response to cytokine; and response to peptide hormone. Located in extracellular region. Is expressed in gut; liver lobe; and renal calyx. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 5233.4), liver E18 (RPKM 1837.1) and 2 other tissues See more
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Genomic context

See Serpina1a in Genome Data Viewer
Location:
12 E; 12 52.98 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (103819554..103829878, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (103853295..103863619, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) preptidase inhibitor, clade A, member 1B pseudogene Neighboring gene serine (or cysteine) preptidase inhibitor, clade A, member 1B pseudogene Neighboring gene serine (or cysteine) preptidase inhibitor, clade A, member 1B pseudogene Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 1C

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117839

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
alpha-1-antitrypsin 1-1
Names
AAT
alpha-1 protease inhibitor 1
alpha-1-antiproteinase
alpha-1-antitrypsin 2
serine (or cysteine) proteinase inhibitor, clade A, member 1a
serine protease inhibitor 1-1
serine protease inhibitor A1a
serpin A1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252569.1NP_001239498.1  alpha-1-antitrypsin 1-1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional exon in the 5' region, which includes an upstream in-frame AUG start codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus, compared to isoform 1.
    Source sequence(s)
    AC098741, AC134902
    Consensus CDS
    CCDS79152.1
    UniProtKB/TrEMBL
    A0A0A0MQA3
    Related
    ENSMUSP00000072652.7, ENSMUST00000072876.12
    Conserved Domains (1) summary
    smart00093
    Location:76433
    SERPIN; SERine Proteinase INhibitors
  2. NM_009243.4NP_033269.1  alpha-1-antitrypsin 1-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_033269.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the predominant transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AC134902, AK146619, CJ238440, W82055
    Consensus CDS
    CCDS26140.1
    UniProtKB/Swiss-Prot
    P07758, Q91XB8
    Related
    ENSMUSP00000082132.7, ENSMUST00000085056.8
    Conserved Domains (1) summary
    smart00093
    Location:53410
    SERPIN; SERine Proteinase INhibitors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    103819554..103829878 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)