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Serpina1a serine (or cysteine) peptidase inhibitor, clade A, member 1A [ Mus musculus (house mouse) ]

Gene ID: 20700, updated on 12-Mar-2017
Official Symbol
Serpina1aprovided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade A, member 1Aprovided by MGI
Primary source
MGI:MGI:891971
See related
Ensembl:ENSMUSG00000066366 Vega:OTTMUSG00000023942
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PI1; Aat2; Dom1; Aat-2; Spi1-1; Spi1-3
Location:
12 E; 12 52.98 cM
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (103853295..103863619, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (105091669..105101829, complement)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) preptidase inhibitor, clade A, member 1B pseudogene Neighboring gene serine (or cysteine) preptidase inhibitor, clade A, member 1B pseudogene Neighboring gene serine (or cysteine) preptidase inhibitor, clade A, member 1B pseudogene Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 1C

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Complement and coagulation cascades, organism-specific biosystem (from KEGG)
    Complement and coagulation cascades, organism-specific biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
  • Complement and coagulation cascades, conserved biosystem (from KEGG)
    Complement and coagulation cascades, conserved biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC117839

Gene Ontology Provided by MGI

Function Evidence Code Pubs
endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
glycoprotein binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protease binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
protein N-linked glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
response to cytokine IDA
Inferred from Direct Assay
more info
PubMed 
response to peptide hormone IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
alpha-1-antitrypsin 1-1
Names
AAT
alpha-1 protease inhibitor 1
alpha-1-antiproteinase
alpha-1-antitrypsin 2
serine (or cysteine) proteinase inhibitor, clade A, member 1a
serine protease inhibitor 1-1
serine protease inhibitor A1a
serpin A1a

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252569.1NP_001239498.1  alpha-1-antitrypsin 1-1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional exon in the 5' region, which includes an upstream in-frame AUG start codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus, compared to isoform 1.
    Source sequence(s)
    AC098741, AC134902
    Consensus CDS
    CCDS79152.1
    UniProtKB/TrEMBL
    A0A0A0MQA3
    Related
    ENSMUSP00000072652, OTTMUSP00000028351, ENSMUST00000072876, OTTMUST00000058509
    Conserved Domains (1) summary
    smart00093
    Location:76433
    SERPIN; SERine Proteinase INhibitors
  2. NM_009243.4NP_033269.1  alpha-1-antitrypsin 1-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_033269.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the predominant transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AC134902, AK146619, CJ238440, W82055
    Consensus CDS
    CCDS26140.1
    UniProtKB/Swiss-Prot
    P07758
    Related
    ENSMUSP00000082132, OTTMUSP00000028352, ENSMUST00000085056, OTTMUST00000058510
    Conserved Domains (1) summary
    smart00093
    Location:53410
    SERPIN; SERine Proteinase INhibitors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

    Range
    103853295..103863619 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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