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AKT1 AKT serine/threonine kinase 1 [ Homo sapiens (human) ]

Gene ID: 207, updated on 29-Mar-2020

Summary

Official Symbol
AKT1provided by HGNC
Official Full Name
AKT serine/threonine kinase 1provided by HGNC
Primary source
HGNC:HGNC:391
See related
Ensembl:ENSG00000142208 MIM:164730
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AKT; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA
Summary
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
Expression
Ubiquitous expression in prostate (RPKM 26.1), lung (RPKM 25.1) and 25 other tissues See more
Orthologs

Genomic context

See AKT1 in Genome Data Viewer
Location:
14q32.33
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (104769349..104795748, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (105235686..105262080, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene adenylosuccinate synthase 1 Neighboring gene uncharacterized LOC107984670 Neighboring gene uncharacterized LOC107987209 Neighboring gene SIVA1 apoptosis inducing factor Neighboring gene uncharacterized LOC102723342 Neighboring gene zinc finger and BTB domain containing 42 Neighboring gene long intergenic non-protein coding RNA 638

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of v-akt murine thymoma viral oncogene homolog 1 (AKT1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
Knockdown of v-akt murine thymoma viral oncogene homolog 1 (AKT1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of IL-6 and IL-8 via the p38 signaling pathway and the PI3K/Akt signaling pathway in astrocytes PubMed
env HIV-1 gp120 activates AKT, ERK1/2, and p38 signaling in tonsil CD4+ T cells. Soluble CD4 inhibits AKT and ERK1/2 activation, but enhances phosphorylation of p38 PubMed
env Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways PubMed
env Gp120-mediated activation of caspase-3 is significantly reduced in cells pretreated with PDGF-B. PDGF-mediated protection against gp120 involves the phosphoinositide (PI)3-kinase/Akt pathway PubMed
env Treatment of human hepatic stellate cells with gp120 significantly increases secretion and gene expression of CCL2, metalloprotease-1 and interleukin-6. Gp120 also induces activation of Akt, NF-kappaB, and p38(MAPK) PubMed
env Downregulation of the Wave2 signaling complex (Tiam-1, Abl, Rac, IRSp53, Wave2, and Arp3) with siRNA reduces HIV-1 Env-mediated cell-cell fusion and virus-cell fusion PubMed
env Insulin-like growth factor-I (IGF-I) and erythropoietin treatment protect against HIV/gp120-mediated neuronal damage in culture and in vivo, in part, through cooperative activation of phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling PubMed
env HIV-1 gp120 induced cell death is inhibited by a CCR5-mediated neuroprotective pathway that involves protein kinase Akt/PKB as an essential component and can be triggered by the CCR5 agonists MIP-1beta and RANTES PubMed
env CD45 modulates HIV-1 gp120-induced apoptosis by regulating Fas ligand induction and activation of the phosphoinositide 3-kinase/Akt pathway PubMed
env Fractalkine (CX3CL1) protects hippocampal neurons from the neurotoxicity induced by the HIV-1 envelope protein gp120, and neuronal CX(3)CR1 receptors and Akt activation are responsible for the neuroprotective effects of fractalkine PubMed
env HIV-1 gp120 downregulates expression of c-Myc, Max, and 14-3-3epsilon proteins, and decreases phosphorylation of ATP-dependent tyrosine kinases (Akt) at Ser-473 in human mesangial cells (HMC) PubMed
Nef nef Recombinant HIV-1 Nef upregulates expression of antiapoptotic proteins BCL2, AKT1, and XIAP in THP-1 cells and primary blood macrophages PubMed
nef HIV-1 Nef interacts with AKT1 and PI3K via its C and N terminal extremity, respectively PubMed
nef Exogenous HIV-1 Nef enters peripheral blood lymphocytes and increases AKT1 phosphorylation PubMed
nef HIV-1 Nef activates AKT1 in peripheral blood lymphocytes and is mediated by PI3K in a dose and time dependent manner PubMed
nef HIV-1 Nef activates protein kinase B (AKT1/PKB) to inhibit autophagy in human mesenchymal stem cells PubMed
nef HIV-1 Nef synergizes with KSHV oncoprotein K1 to activate PI3K/AKT/mTOR signaling pathway, and induces cell proliferation and microtubule formation in endothelial cells PubMed
nef HIV-1 Nef induces phosphorylation of MEK1 at position serine 298, which depends on Pak and Rac activity PubMed
nef HIV-1 Nef synergizes with IL-6 to activate the AKT pathway promoting angiogenesis and tumorigenesis in a chicken chorioallantoic membrane model and nude mice PubMed
nef HIV-1 Nef synergizes with IL-6 to enhance vascular tube formation, cell proliferation, VEGF expression, and phosphorylated AKT activation in human umbilical vein endothelial cells PubMed
nef Incubation of human macrophages with exogenous HIV-1 Nef protein induces phosphorylation of Akt and GSK-3ss, and promotes IL-10 release PubMed
nef HIV-1 Nef decreases levels of AKT phosphorylation in insulin-stimulated adipocytes PubMed
Tat tat HIV-1 Tat-induced activation of ICAM1 and VCAM1 is affected by AKT signalling in hCMEC/D3 cells PubMed
tat HIV-1 Tat increases phosphorylation of ERK1/2, JNK1/2, p38, AKT1, MEK-1, and STAT-1alpha in Muller glia and brain microvascular pericytes PubMed
tat The gene expression of v-akt murine thymoma viral oncogene homolog 1 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC cells PubMed
tat HIV-1 Tat and cocaine treatment activates PI3K and AKT in human pulmonary arterial smooth muscle cells PubMed
tat Ginsenoside Rb1 and miltefosine synergistically abolish the cytoprotective CHME5 cells expressing HIV-1 Tat by inhibiting the AKT pathway PubMed
tat Treatment with HIV-Tat and morphine activates extracellular signal-regulated kinase-1/2 (ERK1/2), upregulates p53 and p21 levels, and downregulates cyclin D1 and Akt levels in human fetal brain-derived neural precursor cells PubMed
tat HIV-1 Tat induces phosphorylation of PI3K, AKT, PTEN, and GSK-3beta activating PI3K and AKT and inactivating PTEN and GSK-3beta in vIL-6 expressing cells PubMed
tat PI3K/Akt, TRPC, and GSK3beta signaling pathways are all involved in PDGF-C mediated neuroprotection against HIV-1 Tat in human neuroblastoma cells PubMed
tat Phosphatidylinositol 3-kinase/Akt signaling pathway is involved in HIV-1 Tat-induced NADPH oxidase stimulation and LTR transactivation PubMed
tat HIV-1 Tat activates AKT kinase through activation of PI3 kinase, resulting in the protection of cells from apoptosis PubMed
tat Lancemaside A1 inhibits the movement of Akt to the plasma membrane, a critical step for Akt activation, and Compound K inhibits Akt phosphorylation in Tat-expressing CHME5 cells PubMed
tat PDGF-BB-mediated protection against HIV-1 Tat and morphine-induced neuron apoptosis involves Akt activation PubMed
tat Epigallocatechin-3-gallate (EGCG)-mediated inhibition of HIV-1 Tat-induced LTR transactivation involves activation of Nrf2 and AMPK signaling pathways and inhibition of AKT signaling pathway in MAGI cells PubMed
tat HIV-1 Tat inhibits autophagy in bystander macrophages/monocytic cells through Tat-mediated activation and phosphorylation of Src-Akt signaling PubMed
tat A Coumarin derivative BPRHIV001 modulates Tat function through a reduction of the p300 protein level and a concordant reduction of phosphorylated Akt PubMed
tat HIV-1 Tat in combination with IFN-gamma and TNF-alpha increases CXCL10 mRNA and protein in human astrocytes through the activation of the p38, Jnk, and Akt signaling pathways and their downstream transcription factors, NF-kappaB and STAT-1alpha PubMed
tat HIV-1 Tat in combination with KSHV kaposin A activates the MEK/ERK, STAT3, and PI3K/Akt signals in NIH3T3 cells PubMed
tat Pro-survival effects of intracellular HIV-1 Tat in a microglial cell line is attributed to activation of the PI-3-kinase (PI3K)/Akt pathway via decreasing expression of PTEN, a negative regulator of the PI-3-K pathway PubMed
tat HIV-1 Tat downregulates CREB transcription factor expression in PC12 neuronal cells through activation of a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway PubMed
tat HIV-1 Tat upregulates several anti-apoptotic genes, including AKT-1, AKT-2, BCL2, BCL-XL, and insulin-like growth factor I in vincristine-treated Kaposi's sarcoma cells PubMed
Vpr vpr PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) is involved in HIV-1 Vpr induced upregulation of IL6 in astrocytes PubMed
vpr PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) is involved in HIV-1 Vpr induced upregulation of CXCL8 (IL8) in astrocytes PubMed
vpr HIV-1 Vpr-induced downregulation of sodium hydrogen exchanger, isoform 1 (NHE1), in Vpr(+) virus infected cells leads to acidification of cells, loss of ezrin, radixin and moesin (ERM) protein complex and decrease of AKT phosphorylation PubMed
vpr HIV-1 Vpr inhibits Akt-induced cytoplasmic translocation of Foxo3a, a subtype of the forkhead transcription factors PubMed
matrix gag HIV-1 MA natural variant S75X induces the phosphorylation of AKT (S473), ERK1/2 (T202/Y204), and ribosomal protein S6 (S235/236) in Epstein-Barr virus (EBV)-infected B-lymphocytes PubMed
gag HIV-1 MA natural variant S75X-mediated proliferation of both Epstein-Barr virus (EBV)-infected primary and fully transformed B-lymphocytes requires AKT, ERK1/2, and STAT3 pathways PubMed
gag HIV-1 p17 induces capillary-like structures in human endothelial cells by binding to CXCR1 and CXCR2, which requires activation of the Akt-dependent ERK signaling pathway PubMed
gag HIV-1 p17 and its C-terminal truncated form of p17 (p17delta36) differentially regulate Akt phosphorylation by reducing and increasing phosphorylation levels of PTEN, respectively PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC99656

Gene Ontology Provided by GOA

Function Evidence Code Pubs
14-3-3 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ATP binding IC
Inferred by Curator
more info
PubMed 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activating protein binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding ISS
Inferred from Sequence or Structural Similarity
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
nitric-oxide synthase regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-3,4-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase C binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein phosphatase 2A binding IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine/tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell costimulation TAS
Traceable Author Statement
more info
 
TOR signaling NAS
Non-traceable Author Statement
more info
PubMed 
activation of protein kinase B activity TAS
Traceable Author Statement
more info
 
activation-induced cell death of T cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
aging IEA
Inferred from Electronic Annotation
more info
 
anoikis NAS
Non-traceable Author Statement
more info
PubMed 
apoptotic mitochondrial changes IEA
Inferred from Electronic Annotation
more info
 
carbohydrate transport IEA
Inferred from Electronic Annotation
more info
 
cell differentiation TAS
Traceable Author Statement
more info
PubMed 
cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell projection organization IEA
Inferred from Electronic Annotation
more info
 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to cadmium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to epidermal growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to granulocyte macrophage colony-stimulating factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to nerve growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
cellular response to oxidised low-density lipoprotein particle stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to prostaglandin E stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to tumor necrosis factor IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to vascular endothelial growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cofactor metabolic process TAS
Traceable Author Statement
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
endocrine pancreas development TAS
Traceable Author Statement
more info
 
epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
establishment of protein localization to mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
excitatory postsynaptic potential NAS
Non-traceable Author Statement
more info
PubMed 
execution phase of apoptosis IEA
Inferred from Electronic Annotation
more info
 
germ cell development IEA
Inferred from Electronic Annotation
more info
 
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
glycogen cell differentiation involved in embryonic placenta development IEA
Inferred from Electronic Annotation
more info
 
hyaluronan metabolic process IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
insulin-like growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-18-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
labyrinthine layer blood vessel development IEA
Inferred from Electronic Annotation
more info
 
lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
maintenance of protein location in mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland epithelial cell differentiation TAS
Traceable Author Statement
more info
PubMed 
maternal placenta development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Notch signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell size IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand TAS
Traceable Author Statement
more info
PubMed 
negative regulation of fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
negative regulation of leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of lymphocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of macroautophagy NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of neuron death NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of plasma membrane long-chain fatty acid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein kinase B signaling TAS
Traceable Author Statement
more info
 
negative regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein kinase activity by protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
negative regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of release of cytochrome c from mitochondria ISS
Inferred from Sequence or Structural Similarity
more info
 
nitric oxide biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation TAS
Traceable Author Statement
more info
PubMed 
peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peripheral nervous system myelin maintenance IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of I-kappaB phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cellular protein metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cyclin-dependent protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endodeoxyribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fibroblast migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glycogen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glycogen biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mitochondrial membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nitric-oxide synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of organ growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein localization to cell surface IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein kinase B signaling TAS
Traceable Author Statement
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell migration TAS
Traceable Author Statement
more info
PubMed 
regulation of glycogen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mRNA stability TAS
Traceable Author Statement
more info
 
regulation of myelination IEA
Inferred from Electronic Annotation
more info
 
regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of nitric-oxide synthase activity TAS
Traceable Author Statement
more info
 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
regulation of translation IEA
Inferred from Electronic Annotation
more info
 
response to UV-A IDA
Inferred from Direct Assay
more info
PubMed 
response to fluid shear stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to food IEA
Inferred from Electronic Annotation
more info
 
response to growth hormone ISS
Inferred from Sequence or Structural Similarity
more info
 
response to heat TAS
Traceable Author Statement
more info
PubMed 
response to insulin-like growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
spinal cord development IEA
Inferred from Electronic Annotation
more info
 
striated muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
ciliary basal body IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
postsynapse IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
spindle IEA
Inferred from Electronic Annotation
more info
 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
RAC-alpha serine/threonine-protein kinase
Names
AKT1m
PKB alpha
RAC-PK-alpha
protein kinase B alpha
proto-oncogene c-Akt
rac protein kinase alpha
serine-threonine protein kinase
v-akt murine thymoma viral oncogene homolog 1
v-akt murine thymoma viral oncogene-like protein 1
NP_001014431.1
NP_001014432.1
NP_005154.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012188.1 RefSeqGene

    Range
    5001..31396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_721

mRNA and Protein(s)

  1. NM_001014431.2NP_001014431.1  RAC-alpha serine/threonine-protein kinase

    See identical proteins and their annotated locations for NP_001014431.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks the 5' exon, but has an upstream alternate 5' exon, as compared to variant 1. Variants 1 and 3 encode the same protein.
    Source sequence(s)
    AL583722, AL590327
    Consensus CDS
    CCDS9994.1
    UniProtKB/Swiss-Prot
    P31749
    UniProtKB/TrEMBL
    B0LPE5
    Related
    ENSP00000384293.2, ENST00000407796.6
    Conserved Domains (2) summary
    cd01241
    Location:4111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05594
    Location:124479
    STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)
  2. NM_001014432.2NP_001014432.1  RAC-alpha serine/threonine-protein kinase

    See identical proteins and their annotated locations for NP_001014432.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks the 5' segment, but has an upstream alternate 5' exon, as compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL583722, AL590327
    Consensus CDS
    CCDS9994.1
    UniProtKB/Swiss-Prot
    P31749
    UniProtKB/TrEMBL
    B0LPE5
    Related
    ENSP00000270202.4, ENST00000349310.7
    Conserved Domains (2) summary
    cd01241
    Location:4111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05594
    Location:124479
    STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)
  3. NM_005163.2NP_005154.2  RAC-alpha serine/threonine-protein kinase

    See identical proteins and their annotated locations for NP_005154.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK122894, BC000479
    Consensus CDS
    CCDS9994.1
    UniProtKB/Swiss-Prot
    P31749
    UniProtKB/TrEMBL
    B0LPE5, B3KVH4
    Related
    ENSP00000450688.1, ENST00000555528.5
    Conserved Domains (2) summary
    cd01241
    Location:4111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05594
    Location:124479
    STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    104769349..104795748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_002957536.1 RNA Sequence

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