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AKT1 AKT serine/threonine kinase 1 [ Homo sapiens (human) ]

Gene ID: 207, updated on 23-Jun-2022

Summary

Official Symbol
AKT1provided by HGNC
Official Full Name
AKT serine/threonine kinase 1provided by HGNC
Primary source
HGNC:HGNC:391
See related
Ensembl:ENSG00000142208 MIM:164730; AllianceGenome:HGNC:391
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AKT; PKB; RAC; PRKBA; PKB-ALPHA; RAC-ALPHA
Summary
This gene encodes one of the three members of the human AKT serine-threonine protein kinase family which are often referred to as protein kinase B alpha, beta, and gamma. These highly similar AKT proteins all have an N-terminal pleckstrin homology domain, a serine/threonine-specific kinase domain and a C-terminal regulatory domain. These proteins are phosphorylated by phosphoinositide 3-kinase (PI3K). AKT/PI3K forms a key component of many signalling pathways that involve the binding of membrane-bound ligands such as receptor tyrosine kinases, G-protein coupled receptors, and integrin-linked kinase. These AKT proteins therefore regulate a wide variety of cellular functions including cell proliferation, survival, metabolism, and angiogenesis in both normal and malignant cells. AKT proteins are recruited to the cell membrane by phosphatidylinositol 3,4,5-trisphosphate (PIP3) after phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) by PI3K. Subsequent phosphorylation of both threonine residue 308 and serine residue 473 is required for full activation of the AKT1 protein encoded by this gene. Phosphorylation of additional residues also occurs, for example, in response to insulin growth factor-1 and epidermal growth factor. Protein phosphatases act as negative regulators of AKT proteins by dephosphorylating AKT or PIP3. The PI3K/AKT signalling pathway is crucial for tumor cell survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating AKT1 which then phosphorylates and inactivates components of the apoptotic machinery. AKT proteins also participate in the mammalian target of rapamycin (mTOR) signalling pathway which controls the assembly of the eukaryotic translation initiation factor 4F (eIF4E) complex and this pathway, in addition to responding to extracellular signals from growth factors and cytokines, is disregulated in many cancers. Mutations in this gene are associated with multiple types of cancer and excessive tissue growth including Proteus syndrome and Cowden syndrome 6, and breast, colorectal, and ovarian cancers. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2020]
Expression
Ubiquitous expression in prostate (RPKM 26.1), lung (RPKM 25.1) and 25 other tissues See more
Orthologs
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Genomic context

See AKT1 in Genome Data Viewer
Location:
14q32.33
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (104769349..104795748, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (99012235..99038624, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (105235686..105262085, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987209 Neighboring gene SIVA1 apoptosis inducing factor Neighboring gene uncharacterized LOC102723342 Neighboring gene Sharpr-MPRA regulatory region 15301 Neighboring gene zinc finger and BTB domain containing 42 Neighboring gene Sharpr-MPRA regulatory region 3976

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Colorectal cancer
MedGen: C0346629 OMIM: 114500 GeneReviews: Lynch Syndrome
Compare labs
Cowden syndrome 6
MedGen: C3554519 OMIM: 615109 GeneReviews: Not available
Compare labs
Familial cancer of breast Compare labs
Neoplasm of ovary
MedGen: C0919267 OMIM: 167000 GeneReviews: Not available
Compare labs
Proteus syndrome
MedGen: C0085261 OMIM: 176920 GeneReviews: Proteus Syndrome
Compare labs

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2022-01-25)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2022-01-25)

ClinGen Genome Curation Page

EBI GWAS Catalog

Description
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of v-akt murine thymoma viral oncogene homolog 1 (AKT1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
Knockdown of v-akt murine thymoma viral oncogene homolog 1 (AKT1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of IL-6 and IL-8 via the p38 signaling pathway and the PI3K/Akt signaling pathway in astrocytes PubMed
env HIV-1 gp120 activates AKT, ERK1/2, and p38 signaling in tonsil CD4+ T cells. Soluble CD4 inhibits AKT and ERK1/2 activation, but enhances phosphorylation of p38 PubMed
env Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways PubMed
env Gp120-mediated activation of caspase-3 is significantly reduced in cells pretreated with PDGF-B. PDGF-mediated protection against gp120 involves the phosphoinositide (PI)3-kinase/Akt pathway PubMed
env Treatment of human hepatic stellate cells with gp120 significantly increases secretion and gene expression of CCL2, metalloprotease-1 and interleukin-6. Gp120 also induces activation of Akt, NF-kappaB, and p38(MAPK) PubMed
env Downregulation of the Wave2 signaling complex (Tiam-1, Abl, Rac, IRSp53, Wave2, and Arp3) with siRNA reduces HIV-1 Env-mediated cell-cell fusion and virus-cell fusion PubMed
env Insulin-like growth factor-I (IGF-I) and erythropoietin treatment protect against HIV/gp120-mediated neuronal damage in culture and in vivo, in part, through cooperative activation of phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling PubMed
env HIV-1 gp120 induced cell death is inhibited by a CCR5-mediated neuroprotective pathway that involves protein kinase Akt/PKB as an essential component and can be triggered by the CCR5 agonists MIP-1beta and RANTES PubMed
env CD45 modulates HIV-1 gp120-induced apoptosis by regulating Fas ligand induction and activation of the phosphoinositide 3-kinase/Akt pathway PubMed
env Fractalkine (CX3CL1) protects hippocampal neurons from the neurotoxicity induced by the HIV-1 envelope protein gp120, and neuronal CX(3)CR1 receptors and Akt activation are responsible for the neuroprotective effects of fractalkine PubMed
env HIV-1 gp120 downregulates expression of c-Myc, Max, and 14-3-3epsilon proteins, and decreases phosphorylation of ATP-dependent tyrosine kinases (Akt) at Ser-473 in human mesangial cells (HMC) PubMed
Nef nef Recombinant HIV-1 Nef upregulates expression of antiapoptotic proteins BCL2, AKT1, and XIAP in THP-1 cells and primary blood macrophages PubMed
nef HIV-1 Nef interacts with AKT1 and PI3K via its C and N terminal extremity, respectively PubMed
nef Exogenous HIV-1 Nef enters peripheral blood lymphocytes and increases AKT1 phosphorylation PubMed
nef HIV-1 Nef activates AKT1 in peripheral blood lymphocytes and is mediated by PI3K in a dose and time dependent manner PubMed
nef HIV-1 Nef activates protein kinase B (AKT1/PKB) to inhibit autophagy in human mesenchymal stem cells PubMed
nef HIV-1 Nef synergizes with KSHV oncoprotein K1 to activate PI3K/AKT/mTOR signaling pathway, and induces cell proliferation and microtubule formation in endothelial cells PubMed
nef HIV-1 Nef induces phosphorylation of MEK1 at position serine 298, which depends on Pak and Rac activity PubMed
nef HIV-1 Nef synergizes with IL-6 to activate the AKT pathway promoting angiogenesis and tumorigenesis in a chicken chorioallantoic membrane model and nude mice PubMed
nef HIV-1 Nef synergizes with IL-6 to enhance vascular tube formation, cell proliferation, VEGF expression, and phosphorylated AKT activation in human umbilical vein endothelial cells PubMed
nef Incubation of human macrophages with exogenous HIV-1 Nef protein induces phosphorylation of Akt and GSK-3ss, and promotes IL-10 release PubMed
nef HIV-1 Nef decreases levels of AKT phosphorylation in insulin-stimulated adipocytes PubMed
Tat tat HIV-1 Tat-induced activation of ICAM1 and VCAM1 is affected by AKT signalling in hCMEC/D3 cells PubMed
tat HIV-1 Tat increases phosphorylation of ERK1/2, JNK1/2, p38, AKT1, MEK-1, and STAT-1alpha in Muller glia and brain microvascular pericytes PubMed
tat The gene expression of v-akt murine thymoma viral oncogene homolog 1 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC cells PubMed
tat HIV-1 Tat and cocaine treatment activates PI3K and AKT in human pulmonary arterial smooth muscle cells PubMed
tat Ginsenoside Rb1 and miltefosine synergistically abolish the cytoprotective CHME5 cells expressing HIV-1 Tat by inhibiting the AKT pathway PubMed
tat Treatment with HIV-Tat and morphine activates extracellular signal-regulated kinase-1/2 (ERK1/2), upregulates p53 and p21 levels, and downregulates cyclin D1 and Akt levels in human fetal brain-derived neural precursor cells PubMed
tat HIV-1 Tat induces phosphorylation of PI3K, AKT, PTEN, and GSK-3beta activating PI3K and AKT and inactivating PTEN and GSK-3beta in vIL-6 expressing cells PubMed
tat PI3K/Akt, TRPC, and GSK3beta signaling pathways are all involved in PDGF-C mediated neuroprotection against HIV-1 Tat in human neuroblastoma cells PubMed
tat Phosphatidylinositol 3-kinase/Akt signaling pathway is involved in HIV-1 Tat-induced NADPH oxidase stimulation and LTR transactivation PubMed
tat HIV-1 Tat activates AKT kinase through activation of PI3 kinase, resulting in the protection of cells from apoptosis PubMed
tat Lancemaside A1 inhibits the movement of Akt to the plasma membrane, a critical step for Akt activation, and Compound K inhibits Akt phosphorylation in Tat-expressing CHME5 cells PubMed
tat PDGF-BB-mediated protection against HIV-1 Tat and morphine-induced neuron apoptosis involves Akt activation PubMed
tat Epigallocatechin-3-gallate (EGCG)-mediated inhibition of HIV-1 Tat-induced LTR transactivation involves activation of Nrf2 and AMPK signaling pathways and inhibition of AKT signaling pathway in MAGI cells PubMed
tat HIV-1 Tat inhibits autophagy in bystander macrophages/monocytic cells through Tat-mediated activation and phosphorylation of Src-Akt signaling PubMed
tat A Coumarin derivative BPRHIV001 modulates Tat function through a reduction of the p300 protein level and a concordant reduction of phosphorylated Akt PubMed
tat HIV-1 Tat in combination with IFN-gamma and TNF-alpha increases CXCL10 mRNA and protein in human astrocytes through the activation of the p38, Jnk, and Akt signaling pathways and their downstream transcription factors, NF-kappaB and STAT-1alpha PubMed
tat HIV-1 Tat in combination with KSHV kaposin A activates the MEK/ERK, STAT3, and PI3K/Akt signals in NIH3T3 cells PubMed
tat Pro-survival effects of intracellular HIV-1 Tat in a microglial cell line is attributed to activation of the PI-3-kinase (PI3K)/Akt pathway via decreasing expression of PTEN, a negative regulator of the PI-3-K pathway PubMed
tat HIV-1 Tat downregulates CREB transcription factor expression in PC12 neuronal cells through activation of a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway PubMed
tat HIV-1 Tat upregulates several anti-apoptotic genes, including AKT-1, AKT-2, BCL2, BCL-XL, and insulin-like growth factor I in vincristine-treated Kaposi's sarcoma cells PubMed
Vpr vpr PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) is involved in HIV-1 Vpr induced upregulation of IL6 in astrocytes PubMed
vpr PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) is involved in HIV-1 Vpr induced upregulation of CXCL8 (IL8) in astrocytes PubMed
vpr HIV-1 Vpr-induced downregulation of sodium hydrogen exchanger, isoform 1 (NHE1), in Vpr(+) virus infected cells leads to acidification of cells, loss of ezrin, radixin and moesin (ERM) protein complex and decrease of AKT phosphorylation PubMed
vpr HIV-1 Vpr inhibits Akt-induced cytoplasmic translocation of Foxo3a, a subtype of the forkhead transcription factors PubMed
matrix gag HIV-1 MA natural variant S75X induces the phosphorylation of AKT (S473), ERK1/2 (T202/Y204), and ribosomal protein S6 (S235/236) in Epstein-Barr virus (EBV)-infected B-lymphocytes PubMed
gag HIV-1 MA natural variant S75X-mediated proliferation of both Epstein-Barr virus (EBV)-infected primary and fully transformed B-lymphocytes requires AKT, ERK1/2, and STAT3 pathways PubMed
gag HIV-1 p17 induces capillary-like structures in human endothelial cells by binding to CXCR1 and CXCR2, which requires activation of the Akt-dependent ERK signaling pathway PubMed
gag HIV-1 p17 and its C-terminal truncated form of p17 (p17delta36) differentially regulate Akt phosphorylation by reducing and increasing phosphorylation levels of PTEN, respectively PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC99656

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 14-3-3 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ATP binding IC
Inferred by Curator
more info
PubMed 
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nitric-oxide synthase regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-3,4-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables potassium channel activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein serine/threonine/tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T cell costimulation TAS
Traceable Author Statement
more info
 
involved_in TOR signaling NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within activation-induced cell death of T cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in anoikis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in apoptotic mitochondrial changes IEA
Inferred from Electronic Annotation
more info
 
involved_in behavioral response to pain IEA
Inferred from Electronic Annotation
more info
 
involved_in carbohydrate transport IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell population proliferation TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to cadmium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to decreased oxygen levels IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to epidermal growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to nerve growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to oxidised low-density lipoprotein particle stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to prostaglandin E stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to tumor necrosis factor IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to vascular endothelial growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
involved_in epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in establishment of protein localization to mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in excitatory postsynaptic potential NAS
Non-traceable Author Statement
more info
PubMed 
involved_in execution phase of apoptosis IEA
Inferred from Electronic Annotation
more info
 
involved_in fibroblast migration NAS
Non-traceable Author Statement
more info
PubMed 
involved_in gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in germ cell development IEA
Inferred from Electronic Annotation
more info
 
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin-like growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in interleukin-18-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in labyrinthine layer blood vessel development IEA
Inferred from Electronic Annotation
more info
 
involved_in lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in maintenance of protein location in mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mammary gland epithelial cell differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in maternal placenta development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of Notch signaling pathway TAS
Traceable Author Statement
more info
 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of long-chain fatty acid import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of lymphocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of macroautophagy NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of neuron death NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein kinase activity by protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of release of cytochrome c from mitochondria ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in nitric oxide biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
involved_in osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-serine phosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peripheral nervous system myelin maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of I-kappaB phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endodeoxyribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of fibroblast migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glycogen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glycogen biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of lipid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitochondrial membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nitric-oxide synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of organ growth IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein localization to cell surface IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein kinase B signaling TAS
Traceable Author Statement
more info
 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell migration TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of glycogen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mRNA stability TAS
Traceable Author Statement
more info
 
involved_in regulation of myelination IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of type B pancreatic cell development TAS
Traceable Author Statement
more info
 
involved_in response to UV-A IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to fluid shear stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to food IEA
Inferred from Electronic Annotation
more info
 
involved_in response to growth factor IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to growth hormone ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to heat IEA
Inferred from Electronic Annotation
more info
 
involved_in response to insulin-like growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in sphingosine-1-phosphate receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in striated muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary basal body IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extrinsic component of cytoplasmic side of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in lamellipodium NAS
Non-traceable Author Statement
more info
PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle IEA
Inferred from Electronic Annotation
more info
 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
RAC-alpha serine/threonine-protein kinase
Names
AKT1m
PKB alpha
RAC-PK-alpha
protein kinase B alpha
proto-oncogene c-Akt
rac protein kinase alpha
serine-threonine protein kinase
v-akt murine thymoma viral oncogene homolog 1
v-akt murine thymoma viral oncogene-like protein 1
NP_001014431.1
NP_001014432.1
NP_001369359.1
NP_001369360.1
NP_001369361.1
NP_001369362.1
NP_005154.2
XP_047287025.1
XP_047287026.1
XP_047287027.1
XP_047287028.1
XP_047287029.1
XP_047287030.1
XP_047287031.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012188.1 RefSeqGene

    Range
    5001..31396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_721

mRNA and Protein(s)

  1. NM_001014431.2NP_001014431.1  RAC-alpha serine/threonine-protein kinase

    See identical proteins and their annotated locations for NP_001014431.1

    Status: REVIEWED

    Source sequence(s)
    AL583722, AL590327
    Consensus CDS
    CCDS9994.1
    UniProtKB/Swiss-Prot
    P31749
    UniProtKB/TrEMBL
    B0LPE5
    Related
    ENSP00000384293.2, ENST00000407796.7
    Conserved Domains (2) summary
    cd01241
    Location:4111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05594
    Location:124479
    STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)
  2. NM_001014432.2NP_001014432.1  RAC-alpha serine/threonine-protein kinase

    See identical proteins and their annotated locations for NP_001014432.1

    Status: REVIEWED

    Source sequence(s)
    AL583722, AL590327
    Consensus CDS
    CCDS9994.1
    UniProtKB/Swiss-Prot
    P31749
    UniProtKB/TrEMBL
    B0LPE5
    Related
    ENSP00000270202.4, ENST00000349310.7
    Conserved Domains (2) summary
    cd01241
    Location:4111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05594
    Location:124479
    STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)
  3. NM_001382430.1NP_001369359.1  RAC-alpha serine/threonine-protein kinase

    Status: REVIEWED

    Source sequence(s)
    AL583722, AL590327
    Related
    ENSP00000497822.1, ENST00000649815.2
    Conserved Domains (2) summary
    cd01241
    Location:4111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05594
    Location:124479
    STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)
  4. NM_001382431.1NP_001369360.1  RAC-alpha serine/threonine-protein kinase

    Status: REVIEWED

    Source sequence(s)
    AL583722, AL590327
    Conserved Domains (2) summary
    cd01241
    Location:4111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05594
    Location:124479
    STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)
  5. NM_001382432.1NP_001369361.1  RAC-alpha serine/threonine-protein kinase

    Status: REVIEWED

    Source sequence(s)
    AL583722, AL590327
    Conserved Domains (2) summary
    cd01241
    Location:4111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05594
    Location:124479
    STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)
  6. NM_001382433.1NP_001369362.1  RAC-alpha serine/threonine-protein kinase

    Status: REVIEWED

    Source sequence(s)
    AL583722, AL590327
    Conserved Domains (2) summary
    cd01241
    Location:4111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05594
    Location:124479
    STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)
  7. NM_005163.2NP_005154.2  RAC-alpha serine/threonine-protein kinase

    See identical proteins and their annotated locations for NP_005154.2

    Status: REVIEWED

    Source sequence(s)
    AK122894, BC000479
    Consensus CDS
    CCDS9994.1
    UniProtKB/Swiss-Prot
    P31749
    UniProtKB/TrEMBL
    B0LPE5, B3KVH4
    Related
    ENSP00000450688.1, ENST00000555528.5
    Conserved Domains (2) summary
    cd01241
    Location:4111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05594
    Location:124479
    STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    104769349..104795748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431075.1XP_047287031.1  RAC-alpha serine/threonine-protein kinase isoform X1

  2. XM_047431074.1XP_047287030.1  RAC-alpha serine/threonine-protein kinase isoform X1

  3. XM_047431069.1XP_047287025.1  RAC-alpha serine/threonine-protein kinase isoform X1

  4. XM_047431071.1XP_047287027.1  RAC-alpha serine/threonine-protein kinase isoform X1

    Related
    ENSP00000451166.1, ENST00000554848.5
  5. XM_047431072.1XP_047287028.1  RAC-alpha serine/threonine-protein kinase isoform X1

  6. XM_047431070.1XP_047287026.1  RAC-alpha serine/threonine-protein kinase isoform X1

  7. XM_047431073.1XP_047287029.1  RAC-alpha serine/threonine-protein kinase isoform X1

    Related
    ENSP00000451828.1, ENST00000554581.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    99012235..99038624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)