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Spa17 sperm autoantigenic protein 17 [ Mus musculus (house mouse) ]

Gene ID: 20686, updated on 26-Sep-2022

Summary

Official Symbol
Spa17provided by MGI
Official Full Name
sperm autoantigenic protein 17provided by MGI
Primary source
MGI:MGI:1333778
See related
Ensembl:ENSMUSG00000001948 AllianceGenome:MGI:1333778
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sp17
Summary
Predicted to enable calmodulin binding activity. Predicted to act upstream of or within binding activity of sperm to zona pellucida. Located in cytoplasm; external side of plasma membrane; and sperm flagellum. Is expressed in several structures, including brain; gonad; heart; hemolymphoid system gland; and lung. Orthologous to human SPA17 (sperm autoantigenic protein 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 108.0) and CNS E11.5 (RPKM 4.0) See more
Orthologs
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Genomic context

See Spa17 in Genome Data Viewer
Location:
9; 9 A4
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (37514590..37525196, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (37603294..37613916, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene neurogranin Neighboring gene predicted gene, 46107 Neighboring gene sialic acid acetylesterase Neighboring gene transforming growth factor beta regulated gene 1 Neighboring gene pannexin 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within binding of sperm to zona pellucida TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cilium ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in sperm fibrous sheath IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sperm fibrous sheath IDA
Inferred from Direct Assay
more info
PubMed 
located_in sperm fibrous sheath ISO
Inferred from Sequence Orthology
more info
 
is_active_in sperm principal piece IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sperm principal piece IDA
Inferred from Direct Assay
more info
PubMed 
located_in sperm principal piece ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sperm surface protein Sp17
Names
band 34
sperm protein 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324545.2NP_001311474.1  sperm surface protein Sp17

    Status: VALIDATED

    Source sequence(s)
    AC160125
    Consensus CDS
    CCDS22982.1
    UniProtKB/Swiss-Prot
    Q62252
    UniProtKB/TrEMBL
    A0A8C6HBC2, Q545M2
    Related
    ENSMUSP00000150651.2, ENSMUST00000214786.2
    Conserved Domains (1) summary
    cd12100
    Location:1250
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
  2. NM_011449.3NP_035579.1  sperm surface protein Sp17

    See identical proteins and their annotated locations for NP_035579.1

    Status: VALIDATED

    Source sequence(s)
    AC160125
    Consensus CDS
    CCDS22982.1
    UniProtKB/Swiss-Prot
    Q62252
    UniProtKB/TrEMBL
    A0A8C6HBC2, Q545M2
    Related
    ENSMUSP00000002013.10, ENSMUST00000002013.11
    Conserved Domains (1) summary
    cd12100
    Location:1250
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

RNA

  1. NR_177074.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC160125

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    37514590..37525196 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242439.4XP_011240741.2  sperm surface protein Sp17 isoform X1