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Sox8 SRY (sex determining region Y)-box 8 [ Mus musculus (house mouse) ]

Gene ID: 20681, updated on 8-Dec-2018

Summary

Official Symbol
Sox8provided by MGI
Official Full Name
SRY (sex determining region Y)-box 8provided by MGI
Primary source
MGI:MGI:98370
See related
Ensembl:ENSMUSG00000024176
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Biased expression in cortex adult (RPKM 9.8), frontal lobe adult (RPKM 9.3) and 11 other tissues See more
Orthologs

Genomic context

See Sox8 in Genome Data Viewer
Location:
17 A3.3; 17 12.69 cM
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (25565893..25570686, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (25702838..25707631, complement)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 33801 Neighboring gene ribosomal protein SA, pseudogene 6 Neighboring gene RIKEN cDNA 2810468N07 gene Neighboring gene lipase maturation factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
Sertoli cell development IEP
Inferred from Expression Pattern
more info
PubMed 
Sertoli cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
adipose tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
astrocyte fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
cell fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
cell maturation IGI
Inferred from Genetic Interaction
more info
PubMed 
cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enteric nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enteric nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
male gonad development IGI
Inferred from Genetic Interaction
more info
PubMed 
metanephric nephron tubule formation IGI
Inferred from Genetic Interaction
more info
PubMed 
morphogenesis of a branching epithelium IGI
Inferred from Genetic Interaction
more info
PubMed 
morphogenesis of an epithelium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of myoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of photoreceptor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
oligodendrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peripheral nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peripheral nervous system development IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of gliogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of kidney development IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of osteoblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of hormone levels IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
renal vesicle induction IMP
Inferred from Mutant Phenotype
more info
PubMed 
retina development in camera-type eye IGI
Inferred from Genetic Interaction
more info
PubMed 
retinal rod cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
ureter morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transcription factor SOX-8
Names
SRY-box containing gene 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011447.3NP_035577.1  transcription factor SOX-8

    See identical proteins and their annotated locations for NP_035577.1

    Status: VALIDATED

    Source sequence(s)
    AK053716, BC085619
    Consensus CDS
    CCDS28521.1
    UniProtKB/Swiss-Prot
    Q04886
    UniProtKB/TrEMBL
    Q543C3
    Related
    ENSMUSP00000025003.3, ENSMUST00000025003.9
    Conserved Domains (2) summary
    cd01388
    Location:98168
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam12444
    Location:1886
    Sox_N; Sox developmental protein N terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

    Range
    25565893..25570686 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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