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Sox7 SRY (sex determining region Y)-box 7 [ Mus musculus (house mouse) ]

Gene ID: 20680, updated on 8-Nov-2022

Summary

Official Symbol
Sox7provided by MGI
Official Full Name
SRY (sex determining region Y)-box 7provided by MGI
Primary source
MGI:MGI:98369
See related
Ensembl:ENSMUSG00000063060 AllianceGenome:MGI:98369
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Acts upstream of or within positive regulation of transcription, DNA-templated and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; reproductive system; and urinary system. Used to study congenital diaphragmatic hernia. Orthologous to human SOX7 (SRY-box transcription factor 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 22.4), heart adult (RPKM 6.0) and 11 other tissues See more
Orthologs
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Genomic context

See Sox7 in Genome Data Viewer
Location:
14; 14 D1
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (64181155..64188181)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (63943706..63950732)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene X-linked Kx blood group related 6 Neighboring gene predicted gene, 41175 Neighboring gene PIN2/TERF1 interacting, telomerase inhibitor 1 Neighboring gene RIKEN cDNA 4930578I06 gene Neighboring gene predicted gene, 36410 Neighboring gene retinitis pigmentosa 1 homolog like 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transcription factor SOX-7
Names
SRY-box containing gene 7
mSOX7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011446.1NP_035576.1  transcription factor SOX-7

    See identical proteins and their annotated locations for NP_035576.1

    Status: PROVISIONAL

    Source sequence(s)
    AB023419
    Consensus CDS
    CCDS27206.1
    UniProtKB/Swiss-Prot
    P40646, Q9R1T6
    UniProtKB/TrEMBL
    Q3U1W5
    Related
    ENSMUSP00000078597.6, ENSMUST00000079652.7
    Conserved Domains (2) summary
    cd01388
    Location:44115
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam12067
    Location:175378
    Sox_C_TAD; Sox C-terminal transactivation domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    64181155..64188181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)