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Sox12 SRY (sex determining region Y)-box 12 [ Mus musculus (house mouse) ]

Gene ID: 20667, updated on 8-Dec-2022

Summary

Official Symbol
Sox12provided by MGI
Official Full Name
SRY (sex determining region Y)-box 12provided by MGI
Primary source
MGI:MGI:98360
See related
Ensembl:ENSMUSG00000051817 AllianceGenome:MGI:98360
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010205A02Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in positive regulation of regulatory T cell differentiation; positive regulation of transcription by RNA polymerase II; and spinal cord development. Part of protein-DNA complex. Is expressed in alimentary system; brain; cranial ganglion; genitourinary system; and neural retina. Orthologous to human SOX12 (SRY-box transcription factor 12). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Sox12 in Genome Data Viewer
Location:
2; 2 G3
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152235531..152239966, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152393611..152398046, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 14164 Neighboring gene ribosomal protein, large, P0 pseudogene Neighboring gene neurensin 2 Neighboring gene VISTA enhancer mm271 Neighboring gene zinc finger, CCHC domain containing 3

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of protein-DNA complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcription factor SOX-12
Names
SRY-box containing gene 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011438.2NP_035568.1  transcription factor SOX-12

    See identical proteins and their annotated locations for NP_035568.1

    Status: VALIDATED

    Source sequence(s)
    AL928568, BG228657, BQ180104, CA749985, CB245116
    Consensus CDS
    CCDS38274.1
    UniProtKB/Swiss-Prot
    Q04890, Q6NXL2
    Related
    ENSMUSP00000138293.2, ENSMUST00000182625.2
    Conserved Domains (1) summary
    cd01388
    Location:39110
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    152235531..152239966 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)