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Sod3 superoxide dismutase 3, extracellular [ Mus musculus (house mouse) ]

Gene ID: 20657, updated on 8-Dec-2022

Summary

Official Symbol
Sod3provided by MGI
Official Full Name
superoxide dismutase 3, extracellularprovided by MGI
Primary source
MGI:MGI:103181
See related
Ensembl:ENSMUSG00000072941 AllianceGenome:MGI:103181
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EC-SOD
Summary
Enables superoxide dismutase activity. Acts upstream of or within response to hypoxia. Located in extracellular space. Colocalizes with collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and neural ectoderm. Human ortholog(s) of this gene implicated in several diseases, including coronary artery disease (multiple); diabetes mellitus (multiple); diabetic retinopathy; lung disease (multiple); and polyneuropathy. Orthologous to human SOD3 (superoxide dismutase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 494.2), lung adult (RPKM 264.4) and 10 other tissues See more
Orthologs
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Genomic context

See Sod3 in Genome Data Viewer
Location:
5 C1; 5 27.92 cM
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (52521146..52527080)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (52363804..52369738)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9230114K14 gene Neighboring gene RIKEN cDNA C130083M11 gene Neighboring gene coiled-coil domain containing 149 Neighboring gene predicted gene 3519 Neighboring gene leucine-rich repeat LGI family, member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC13799

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antioxidant activity IEA
Inferred from Electronic Annotation
more info
 
enables copper ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables superoxide dismutase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables superoxide dismutase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables superoxide dismutase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in blood vessel diameter maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in removal of superoxide radicals IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to copper ion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in superoxide metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi lumen TAS
Traceable Author Statement
more info
 
colocalizes_with collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
extracellular superoxide dismutase [Cu-Zn]
Names
extracellular superoxide dismutase
NP_035565.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011435.3NP_035565.1  extracellular superoxide dismutase [Cu-Zn] precursor

    See identical proteins and their annotated locations for NP_035565.1

    Status: VALIDATED

    Source sequence(s)
    AC102735, U38261
    Consensus CDS
    CCDS19283.1
    UniProtKB/Swiss-Prot
    O09164
    UniProtKB/TrEMBL
    Q542X9
    Related
    ENSMUSP00000098768.5, ENSMUST00000101208.6
    Conserved Domains (1) summary
    pfam00080
    Location:91224
    Sod_Cu; Copper/zinc superoxide dismutase (SODC)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    52521146..52527080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)