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Snrpc U1 small nuclear ribonucleoprotein C [ Mus musculus (house mouse) ]

Gene ID: 20630, updated on 8-Feb-2024

Summary

Official Symbol
Snrpcprovided by MGI
Official Full Name
U1 small nuclear ribonucleoprotein Cprovided by MGI
Primary source
MGI:MGI:109489
See related
Ensembl:ENSMUSG00000024217 AllianceGenome:MGI:109489
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
U1C; U1-C; Snrp1c
Summary
Predicted to enable several functions, including RNA binding activity; U1 snRNP binding activity; and protein homodimerization activity. Predicted to be involved in mRNA 5'-splice site recognition and spliceosomal snRNP assembly. Predicted to be located in Cajal body. Predicted to be part of U1 snRNP. Human ortholog(s) of this gene implicated in connective tissue disease; mixed connective tissue disease; and systemic lupus erythematosus. Orthologous to human SNRPC (small nuclear ribonucleoprotein polypeptide C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 61.0), duodenum adult (RPKM 57.2) and 28 other tissues See more
Orthologs
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Genomic context

See Snrpc in Genome Data Viewer
Location:
17 A3.3; 17 14.59 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28059002..28070942)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (27840028..27851968)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene SAM pointed domain containing ets transcription factor Neighboring gene inflammation and lipid regulator with UBA-like and NBR1-like domains Neighboring gene STARR-seq mESC enhancer starr_42174 Neighboring gene ribosomal protein S2, pseudogene 9 Neighboring gene STARR-positive B cell enhancer ABC_E2475 Neighboring gene STARR-positive B cell enhancer ABC_E4198 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27976840-27977098 Neighboring gene bridge-like lipid transfer protein family member 3A Neighboring gene STARR-positive B cell enhancer ABC_E7504 Neighboring gene TATA-box binding protein associated factor 11 Neighboring gene ankyrin repeat and SAM domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables U1 snRNP binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables pre-mRNA 5'-splice site binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in mRNA 5'-splice site recognition IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in spliceosomal snRNP assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
 
part_of U1 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of U1 snRNP ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
U1 small nuclear ribonucleoprotein C
Names
U1 small nuclear ribonucleoprotein 1C
U1 snRNP C
U1 snRNP protein C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001413574.1NP_001400503.1  U1 small nuclear ribonucleoprotein C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126040
    UniProtKB/TrEMBL
    A0A3B2WCR6
    Related
    ENSMUSP00000156644.2, ENSMUST00000233657.2
  2. NM_001413575.1NP_001400504.1  U1 small nuclear ribonucleoprotein C isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC126040
    UniProtKB/TrEMBL
    A0A3B2W450
  3. NM_001413576.1NP_001400505.1  U1 small nuclear ribonucleoprotein C isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC126040
    UniProtKB/TrEMBL
    A0A3B2W450
    Related
    ENSMUSP00000156747.2, ENSMUST00000233752.2
  4. NM_001413577.1NP_001400506.1  U1 small nuclear ribonucleoprotein C isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC126040
  5. NM_011432.3NP_035562.1  U1 small nuclear ribonucleoprotein C isoform 1

    See identical proteins and their annotated locations for NP_035562.1

    Status: VALIDATED

    Source sequence(s)
    AC126040
    Consensus CDS
    CCDS28570.1
    UniProtKB/Swiss-Prot
    Q62241
    UniProtKB/TrEMBL
    Q569X3
    Related
    ENSMUSP00000063976.8, ENSMUST00000071006.9
    Conserved Domains (1) summary
    pfam06220
    Location:138
    zf-U1; U1 zinc finger

RNA

  1. NR_182164.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC126040

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    28059002..28070942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249614.1XP_030105474.1  U1 small nuclear ribonucleoprotein C isoform X1