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Snap23 synaptosomal-associated protein 23 [ Mus musculus (house mouse) ]

Gene ID: 20619, updated on 3-May-2025
Official Symbol
Snap23provided by MGI
Official Full Name
synaptosomal-associated protein 23provided by MGI
Primary source
MGI:MGI:109356
See related
Ensembl:ENSMUSG00000027287 AllianceGenome:MGI:109356
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sndt; 23kDa; Syndet; SNAP-23
Summary
Predicted to enable SNAP receptor activity and syntaxin binding activity. Acts upstream of or within exocytosis. Located in cytoplasmic vesicle and plasma membrane. Part of SNARE complex. Is expressed in cerebral cortex ventricular layer; cortical plate; and testis. Orthologous to human SNAP23 (synaptosome associated protein 23). [provided by Alliance of Genome Resources, May 2025]
Expression
Broad expression in placenta adult (RPKM 10.3), bladder adult (RPKM 8.3) and 24 other tissues See more
Orthologs
human all
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See Snap23 in Genome Data Viewer
Location:
2 60.37 cM; 2 E5
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (120398137..120436829)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (120567655..120601255)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4931402G19 gene Neighboring gene STARR-seq mESC enhancer starr_05508 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:120308865-120309066 Neighboring gene calpain 3 Neighboring gene STARR-seq mESC enhancer starr_05509 Neighboring gene zinc finger protein 106 Neighboring gene STARR-seq mESC enhancer starr_05510 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:120393240-120393349 Neighboring gene STARR-seq mESC enhancer starr_05511 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:120435029-120435138 Neighboring gene STARR-seq mESC enhancer starr_05512 Neighboring gene leucine rich repeat containing 57 Neighboring gene STARR-positive B cell enhancer ABC_E414 Neighboring gene HAUS augmin-like complex, subunit 2 Neighboring gene StAR related lipid transfer domain containing 9 Neighboring gene STARR-seq mESC enhancer starr_05514 Neighboring gene codanin 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. Deletion of SNAP-23 results in pre-implantation embryonic lethality in mice. Suh YH, et al. PLoS One, 2011 Mar 29. PMID 21479242, Free PMC Article
  2. Syndet is a novel SNAP-25 related protein expressed in many tissues. Wang G, et al. J Cell Sci, 1997 Feb. PMID 9067602
  3. Induction of synaptosomal-associated protein-23 kD (SNAP-23) by various cytokines. Morikawa Y, et al. Blood, 1998 Jul 1. PMID 9639508
  4. Lipid droplets interact with mitochondria using SNAP23. Jägerström S, et al. Cell Biol Int, 2009 Sep. PMID 19524684
  5. SNARE protein expression in synaptic terminals and astrocytes in the adult hippocampus: a comparative analysis. Schubert V, et al. Glia, 2011 Oct. PMID 21656854

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SNAP-25, but not SNAP-23, is essential for photoreceptor development, survival, and function in mice.
    Title: SNAP-25, but not SNAP-23, is essential for photoreceptor development, survival, and function in mice.
  2. The synaptosome-associated protein 23 (SNAP23) is necessary for proper myogenesis.
    Title: The synaptosome-associated protein 23 (SNAP23) is necessary for proper myogenesis.
  3. SNAP23 is essential for platelet and mast cell development and required in connective tissue mast cells for anaphylaxis.
    Title: SNAP23 is essential for platelet and mast cell development and required in connective tissue mast cells for anaphylaxis.
  4. SNAP23 deficiency causes severe brain dysplasia through the loss of radial glial cell polarity.
    Title: SNAP23 deficiency causes severe brain dysplasia through the loss of radial glial cell polarity.
  5. Reduction in SNAP-23 Alters Microfilament Organization in Myofibrobastic Hepatic Stellate Cells.
    Title: Reduction in SNAP-23 Alters Microfilament Organization in Myofibrobastic Hepatic Stellate Cells.
  6. The Kif5-SNAP23 complex interacts with mGlu1a receptor.
    Title: SNAP23-Kif5 complex controls mGlu1 receptor trafficking.
  7. Data demonstrate a role for SNAP23 in the control of adipocytemacroautophagy and programmed cell death through an ATG9-dependent, but ATG7-independent, pathway regulating BAX protein levels and BAX activation.
    Title: SNAP23 regulates BAX-dependent adipocyte programmed cell death independently of canonical macroautophagy.
  8. Findings suggest that stx11 regulates the stimulus-dependent transport of TLR4 to the plasma membrane by cooperating with SNAP-23 in macrophages. Our results clarify the regulatory mechanisms underlying intracellular transport of TLR4 and have implications for microbial pathogenesis and immune responses.
    Title: Syntaxin 11 regulates the stimulus-dependent transport of Toll-like receptor 4 to the plasma membrane by cooperating with SNAP-23 in macrophages.
  9. SNAP-23 phosphorylation at Ser95 played an important role in the regulation of SNARE-dependent membrane fusion during FcR-mediated phagocytosis.
    Title: Phosphorylation of SNAP-23 at Ser95 causes a structural alteration and negatively regulates Fc receptor-mediated phagosome formation and maturation in macrophages.
  10. PKM2 promotes tumor cell exosome release via phosphorylating protein SNAP23.
    Title: Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23.
Submit: New GeneRIF Correction See all GeneRIFs (34)

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNAP receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables syntaxin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in histamine secretion by mast cell ISO
Inferred from Sequence Orthology
more info
  
involved_in membrane fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle priming IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport in synapse ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SNARE complex ISO
Inferred from Sequence Orthology
more info
  
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in azurophil granule ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
located_in specific granule ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
synaptosomal-associated protein 23
Names
synaptosomal-associated protein, 23kD
vesicle-membrane fusion protein SNAP-23

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177792.2 → NP_001171263.1  synaptosomal-associated protein 23 isoform a

    See identical proteins and their annotated locations for NP_001171263.1

    Status: VALIDATED

    Source sequence(s)
    AL772299
    Consensus CDS
    CCDS50681.1
    UniProtKB/TrEMBL
    Q9D3L3
    Related
    ENSMUSP00000112138.2, ENSMUST00000116437.8
    Conserved Domains (3) summary
    cd15884
    Location:159 → 217
    SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
    cd15895
    Location:9 → 75
    SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
    pfam00835
    Location:100 → 157
    SNAP-25; SNAP-25 family

  2. NM_001177793.2 → NP_001171264.1  synaptosomal-associated protein 23 isoform b

    See identical proteins and their annotated locations for NP_001171264.1

    Status: VALIDATED

    Source sequence(s)
    AL772299
    Consensus CDS
    CCDS16622.1
    UniProtKB/Swiss-Prot
    O09044, O35620
    UniProtKB/TrEMBL
    A2AKH4
    Related
    ENSMUSP00000028743.4, ENSMUST00000028743.10
    Conserved Domains (3) summary
    cd15884
    Location:148 → 206
    SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
    cd15895
    Location:9 → 75
    SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
    pfam00835
    Location:86 → 146
    SNAP-25; SNAP-25 family

  3. NM_001412626.1 → NP_001399555.1  synaptosomal-associated protein 23 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL772299
    UniProtKB/Swiss-Prot
    O09044, O35620
    UniProtKB/TrEMBL
    A2AKH4

  4. NM_001412627.1 → NP_001399556.1  synaptosomal-associated protein 23 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL772299
    UniProtKB/Swiss-Prot
    O09044, O35620
    UniProtKB/TrEMBL
    A2AKH4

  5. NM_001412628.1 → NP_001399557.1  synaptosomal-associated protein 23 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL772299

  6. NM_001412629.1 → NP_001399558.1  synaptosomal-associated protein 23 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL772299

  7. NM_001412630.1 → NP_001399559.1  synaptosomal-associated protein 23 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL772299
    UniProtKB/TrEMBL
    B0R030
    Related
    ENSMUSP00000116935.2, ENSMUST00000142278.2

  8. NM_001412631.1 → NP_001399560.1  synaptosomal-associated protein 23 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL772299

  9. NM_001412632.1 → NP_001399561.1  synaptosomal-associated protein 23 isoform h

    Status: VALIDATED

    Source sequence(s)
    AL772299

  10. NM_001412633.1 → NP_001399562.1  synaptosomal-associated protein 23 isoform i

    Status: VALIDATED

    Source sequence(s)
    AL772299

  11. NM_009222.4 → NP_033248.1  synaptosomal-associated protein 23 isoform b

    See identical proteins and their annotated locations for NP_033248.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate, in-frame, exon, compared to variant 1. Variants 2 and 3 encode the same protein (isoform b).
    Source sequence(s)
    AL772299
    Consensus CDS
    CCDS16622.1
    UniProtKB/Swiss-Prot
    O09044, O35620
    UniProtKB/TrEMBL
    A2AKH4
    Related
    ENSMUSP00000106339.3, ENSMUST00000110711.9
    Conserved Domains (3) summary
    cd15884
    Location:148 → 206
    SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
    cd15895
    Location:9 → 75
    SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
    pfam00835
    Location:86 → 146
    SNAP-25; SNAP-25 family

RNA

  1. NR_182010.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772299

  2. NR_182011.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772299

  3. NR_182012.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772299

  4. NR_182013.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772299

  5. NR_182014.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772299

  6. NR_182015.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772299

  7. NR_182016.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772299

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    120398137..120436829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499056.5 → XP_006499119.1  synaptosomal-associated protein 23 isoform X1

    See identical proteins and their annotated locations for XP_006499119.1

    UniProtKB/TrEMBL
    Q9D3L3
    Conserved Domains (3) summary
    cd15884
    Location:159 → 217
    SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
    cd15895
    Location:9 → 75
    SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
    pfam00835
    Location:100 → 157
    SNAP-25; SNAP-25 family

  2. XM_006499054.5 → XP_006499117.1  synaptosomal-associated protein 23 isoform X1

    See identical proteins and their annotated locations for XP_006499117.1

    UniProtKB/TrEMBL
    Q9D3L3
    Conserved Domains (3) summary
    cd15884
    Location:159 → 217
    SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
    cd15895
    Location:9 → 75
    SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
    pfam00835
    Location:100 → 157
    SNAP-25; SNAP-25 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O09044.1 GenPept UniProtKB/Swiss-Prot:O09044

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