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Snap23 synaptosomal-associated protein 23 [ Mus musculus (house mouse) ]

Gene ID: 20619, updated on 8-Dec-2022

Summary

Official Symbol
Snap23provided by MGI
Official Full Name
synaptosomal-associated protein 23provided by MGI
Primary source
MGI:MGI:109356
See related
Ensembl:ENSMUSG00000027287 AllianceGenome:MGI:109356
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sndt; 23kDa; Syndet; SNAP-23
Summary
Predicted to enable SNAP receptor activity and syntaxin binding activity. Acts upstream of or within exocytosis. Located in cytoplasmic vesicle and plasma membrane. Part of SNARE complex. Is expressed in testis. Orthologous to human SNAP23 (synaptosome associated protein 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 10.3), bladder adult (RPKM 8.3) and 24 other tissues See more
Orthologs
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Genomic context

See Snap23 in Genome Data Viewer
Location:
2 60.37 cM; 2 E5
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (120398137..120431885)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (120567655..120601255)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4931402G19 gene Neighboring gene calpain 3 Neighboring gene zinc finger protein 106 Neighboring gene leucine rich repeat containing 57 Neighboring gene HAUS augmin-like complex, subunit 2 Neighboring gene START domain containing 9 Neighboring gene congenital dyserythropoietic anemia, type I (human)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SNAP receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables syntaxin binding ISO
Inferred from Sequence Orthology
more info
 
enables syntaxin-1 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histamine secretion by mast cell ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in synaptic vesicle priming IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle-mediated transport in synapse ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
part_of SNARE complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SNARE complex ISO
Inferred from Sequence Orthology
more info
 
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
 
located_in azurophil granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
located_in specific granule ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
synaptosomal-associated protein 23
Names
synaptosomal-associated protein, 23kD
vesicle-membrane fusion protein SNAP-23

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177792.2NP_001171263.1  synaptosomal-associated protein 23 isoform a

    See identical proteins and their annotated locations for NP_001171263.1

    Status: VALIDATED

    Source sequence(s)
    AL772299
    Consensus CDS
    CCDS50681.1
    UniProtKB/Swiss-Prot
    O09044
    UniProtKB/TrEMBL
    A0A8C6I917, Q9D3L3
    Related
    ENSMUSP00000112138.2, ENSMUST00000116437.8
    Conserved Domains (3) summary
    cd15884
    Location:159217
    SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
    cd15895
    Location:975
    SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
    pfam00835
    Location:100157
    SNAP-25; SNAP-25 family
  2. NM_001177793.2NP_001171264.1  synaptosomal-associated protein 23 isoform b

    See identical proteins and their annotated locations for NP_001171264.1

    Status: VALIDATED

    Source sequence(s)
    AL772299
    Consensus CDS
    CCDS16622.1
    UniProtKB/Swiss-Prot
    O09044, O35620
    UniProtKB/TrEMBL
    A0A8C6ICG1, A2AKH4
    Related
    ENSMUSP00000028743.4, ENSMUST00000028743.10
    Conserved Domains (3) summary
    cd15884
    Location:148206
    SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
    cd15895
    Location:975
    SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
    pfam00835
    Location:86146
    SNAP-25; SNAP-25 family
  3. NM_001412626.1NP_001399555.1  synaptosomal-associated protein 23 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL772299
    UniProtKB/Swiss-Prot
    O35620
    UniProtKB/TrEMBL
    A0A8C6ICG1, A2AKH4
  4. NM_001412627.1NP_001399556.1  synaptosomal-associated protein 23 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL772299
    UniProtKB/Swiss-Prot
    O35620
    UniProtKB/TrEMBL
    A0A8C6ICG1, A2AKH4
  5. NM_001412628.1NP_001399557.1  synaptosomal-associated protein 23 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL772299
  6. NM_001412629.1NP_001399558.1  synaptosomal-associated protein 23 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL772299
  7. NM_001412630.1NP_001399559.1  synaptosomal-associated protein 23 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL772299
  8. NM_001412631.1NP_001399560.1  synaptosomal-associated protein 23 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL772299
  9. NM_001412632.1NP_001399561.1  synaptosomal-associated protein 23 isoform h

    Status: VALIDATED

    Source sequence(s)
    AL772299
  10. NM_001412633.1NP_001399562.1  synaptosomal-associated protein 23 isoform i

    Status: VALIDATED

    Source sequence(s)
    AL772299
  11. NM_009222.4NP_033248.1  synaptosomal-associated protein 23 isoform b

    See identical proteins and their annotated locations for NP_033248.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate, in-frame, exon, compared to variant 1. Variants 2 and 3 encode the same protein (isoform b).
    Source sequence(s)
    AL772299
    Consensus CDS
    CCDS16622.1
    UniProtKB/Swiss-Prot
    O09044, O35620
    UniProtKB/TrEMBL
    A0A8C6ICG1, A2AKH4
    Related
    ENSMUSP00000106339.3, ENSMUST00000110711.9
    Conserved Domains (3) summary
    cd15884
    Location:148206
    SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
    cd15895
    Location:975
    SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
    pfam00835
    Location:86146
    SNAP-25; SNAP-25 family

RNA

  1. NR_182010.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772299
  2. NR_182011.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772299
  3. NR_182012.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772299
  4. NR_182013.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772299
  5. NR_182014.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772299
  6. NR_182015.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772299
  7. NR_182016.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772299

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    120398137..120431885
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499056.5XP_006499119.1  synaptosomal-associated protein 23 isoform X1

    See identical proteins and their annotated locations for XP_006499119.1

    UniProtKB/TrEMBL
    A0A8C6I917, Q9D3L3
    Conserved Domains (3) summary
    cd15884
    Location:159217
    SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
    cd15895
    Location:975
    SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
    pfam00835
    Location:100157
    SNAP-25; SNAP-25 family
  2. XM_006499054.5XP_006499117.1  synaptosomal-associated protein 23 isoform X1

    See identical proteins and their annotated locations for XP_006499117.1

    UniProtKB/TrEMBL
    A0A8C6I917, Q9D3L3
    Conserved Domains (3) summary
    cd15884
    Location:159217
    SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
    cd15895
    Location:975
    SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
    pfam00835
    Location:100157
    SNAP-25; SNAP-25 family
  3. XM_006499057.5XP_006499120.1  synaptosomal-associated protein 23 isoform X2

    UniProtKB/Swiss-Prot
    O09044
    UniProtKB/TrEMBL
    A2AKH4
    Conserved Domains (3) summary
    cd15884
    Location:148206
    SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
    cd15895
    Location:975
    SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
    pfam00835
    Location:86146
    SNAP-25; SNAP-25 family