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Snca synuclein, alpha [ Mus musculus (house mouse) ]

Gene ID: 20617, updated on 26-Jul-2021

Summary

Official Symbol
Sncaprovided by MGI
Official Full Name
synuclein, alphaprovided by MGI
Primary source
MGI:MGI:1277151
See related
Ensembl:ENSMUSG00000025889
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
al; alp; NACP; alphaSYN; alpha-Syn
Expression
Biased expression in liver E14 (RPKM 144.4), liver E14.5 (RPKM 119.8) and 10 other tissues See more
Orthologs
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Genomic context

See Snca in Genome Data Viewer
Location:
6 B3; 6 29.15 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (60708557..60806839, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (60731573..60829855, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (60681567..60779849, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38823 Neighboring gene predicted gene, 35386 Neighboring gene MAGE family member B16, pseudogene 2 Neighboring gene multimerin 1 Neighboring gene protein phosphatase 6, catalytic subunit pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (9)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables SNARE binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables arachidonic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables copper ion binding ISO
Inferred from Sequence Orthology
more info
 
enables cuprous ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cuprous ion binding ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
enables dynein complex binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables ferrous iron binding ISO
Inferred from Sequence Orthology
more info
 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipase binding ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables tau protein binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in SNARE complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in SNARE complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adult locomotory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in behavioral response to cocaine ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to copper ion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within chemical synaptic transmission IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within dopamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dopamine metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within membrane organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within microglial cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitochondrial ATP synthesis coupled electron transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitochondrial membrane organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of chaperone-mediated autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of dopamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of dopamine uptake involved in synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of histone acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of norepinephrine uptake ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of serotonin uptake ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of thrombin-activated receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transporter activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neutral lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phospholipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of SNARE complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hydrogen peroxide catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inositol phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of neurotransmitter secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor recycling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein complex oligomerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein tetramerization ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of acyl-CoA biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of acyl-CoA biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of dopamine secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of dopamine secretion TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of glutamate secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of macrophage activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT acts_upstream_of_or_within regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuron death IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of neurotransmitter secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of norepinephrine uptake ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of phospholipase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of presynapse assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to drug IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to interferon-gamma ISO
Inferred from Sequence Orthology
more info
 
involved_in response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
involved_in response to iron(II) ion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in response to magnesium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within synapse organization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within synaptic transmission, dopaminergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in synaptic vesicle endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle priming ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within synaptic vesicle transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
is_active_in axon terminus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in inclusion body IDA
Inferred from Direct Assay
more info
PubMed 
located_in inclusion body ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with platelet alpha granule membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in ribosome ISO
Inferred from Sequence Orthology
more info
 
located_in rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in supramolecular fiber ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
alpha-synuclein
Names
non-A beta component of AD amyloid
non-A4 component of amyloid

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042451.2NP_001035916.1  alpha-synuclein

    See identical proteins and their annotated locations for NP_001035916.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC046764, BY782503
    Consensus CDS
    CCDS20201.1
    UniProtKB/Swiss-Prot
    O55042
    Related
    ENSMUSP00000109907.4, ENSMUST00000114268.5
    Conserved Domains (1) summary
    pfam01387
    Location:1131
    Synuclein
  2. NM_009221.2NP_033247.1  alpha-synuclein

    See identical proteins and their annotated locations for NP_033247.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF179273, BC046764
    Consensus CDS
    CCDS20201.1
    UniProtKB/Swiss-Prot
    O55042
    Related
    ENSMUSP00000126067.2, ENSMUST00000163779.8
    Conserved Domains (1) summary
    pfam01387
    Location:1131
    Synuclein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    60708557..60806839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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