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Snca synuclein, alpha [ Mus musculus (house mouse) ]

Gene ID: 20617, updated on 18-Sep-2018

Summary

Official Symbol
Sncaprovided by MGI
Official Full Name
synuclein, alphaprovided by MGI
Primary source
MGI:MGI:1277151
See related
Ensembl:ENSMUSG00000025889 Vega:OTTMUSG00000057624
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NACP; alphaSYN; alpha-Syn
Expression
Biased expression in liver E14 (RPKM 144.4), liver E14.5 (RPKM 119.8) and 10 other tissues See more
Orthologs

Genomic context

See Snca in Genome Data Viewer
Location:
6 B3; 6 29.15 cM
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (60731573..60829855, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (60681567..60779849, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 38823 Neighboring gene predicted gene, 35386 Neighboring gene melanoma antigen family B, 16, pseudogene 2 Neighboring gene multimerin 1 Neighboring gene protein phosphatase 6, catalytic subunit pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Endonuclease-mediated (2) 

Pathways from BioSystems

  • Alzheimer's disease, organism-specific biosystem (from KEGG)
    Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
  • Alzheimer's disease, conserved biosystem (from KEGG)
    Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
  • Alzheimers Disease, organism-specific biosystem (from WikiPathways)
    Alzheimers Disease, organism-specific biosystemThis pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. This pathway was adapted from KEGG on 10/7/2011. Note: mitochondria...
  • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
  • Parkinson's disease, organism-specific biosystem (from KEGG)
    Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...
  • Parkinsons Disease Pathway, organism-specific biosystem (from WikiPathways)
    Parkinsons Disease Pathway, organism-specific biosystemMost people with Parkinson's disease have idiopathic Parkinson's disease (having no specific known cause). A small proportion of cases, however, can be attributed to known genetic factors. Mutations ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
 
actin binding ISO
Inferred from Sequence Orthology
more info
 
alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
arachidonic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
copper ion binding ISO
Inferred from Sequence Orthology
more info
 
cuprous ion binding ISO
Inferred from Sequence Orthology
more info
 
cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
dynein complex binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
ferrous iron binding ISO
Inferred from Sequence Orthology
more info
 
histone binding IDA
Inferred from Direct Assay
more info
PubMed 
histone binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
kinesin binding ISO
Inferred from Sequence Orthology
more info
 
magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
microtubule binding ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
phospholipase binding ISO
Inferred from Sequence Orthology
more info
 
phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
tau protein binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
adult locomotory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
behavioral response to cocaine ISO
Inferred from Sequence Orthology
more info
 
cellular response to copper ion ISO
Inferred from Sequence Orthology
more info
 
cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
chemical synaptic transmission IGI
Inferred from Genetic Interaction
more info
PubMed 
dopamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
dopamine metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
microglial cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial ATP synthesis coupled electron transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial membrane organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of chaperone-mediated autophagy ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of dopamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of dopamine uptake involved in synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
negative regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of histone acetylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of norepinephrine uptake ISO
Inferred from Sequence Orthology
more info
 
negative regulation of platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of serotonin uptake ISO
Inferred from Sequence Orthology
more info
 
negative regulation of thrombin-activated receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transporter activity ISO
Inferred from Sequence Orthology
more info
 
neutral lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process ISO
Inferred from Sequence Orthology
more info
 
phospholipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of hydrogen peroxide catabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of inositol phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neurotransmitter secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of receptor recycling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein destabilization ISO
Inferred from Sequence Orthology
more info
 
receptor internalization ISO
Inferred from Sequence Orthology
more info
 
regulation of acyl-CoA biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of acyl-CoA biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of dopamine secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of dopamine secretion TAS
Traceable Author Statement
more info
PubMed 
regulation of glutamate secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of long-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of macrophage activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
regulation of neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neurotransmitter secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of norepinephrine uptake ISO
Inferred from Sequence Orthology
more info
 
regulation of phospholipase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of presynapse assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
response to drug IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to interferon-gamma ISO
Inferred from Sequence Orthology
more info
 
response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
response to iron(II) ion ISO
Inferred from Sequence Orthology
more info
 
response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
response to magnesium ion ISO
Inferred from Sequence Orthology
more info
 
synapse organization IGI
Inferred from Genetic Interaction
more info
PubMed 
synaptic transmission, dopaminergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic vesicle endocytosis EXP
Inferred from Experiment
more info
PubMed 
synaptic vesicle endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic vesicle transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
axon ISO
Inferred from Sequence Orthology
more info
 
axon terminus ISO
Inferred from Sequence Orthology
more info
 
cell cortex ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extracellular region ISO
Inferred from Sequence Orthology
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
growth cone ISO
Inferred from Sequence Orthology
more info
 
inclusion body IDA
Inferred from Direct Assay
more info
PubMed 
inclusion body ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
 
mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nuclear outer membrane ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with platelet alpha granule membrane ISO
Inferred from Sequence Orthology
more info
 
presynapse ISO
Inferred from Sequence Orthology
more info
 
ribosome ISO
Inferred from Sequence Orthology
more info
 
rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
supramolecular fiber ISO
Inferred from Sequence Orthology
more info
 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
alpha-synuclein
Names
non-A beta component of AD amyloid
non-A4 component of amyloid

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042451.2NP_001035916.1  alpha-synuclein

    See identical proteins and their annotated locations for NP_001035916.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC046764, BY782503
    Consensus CDS
    CCDS20201.1
    UniProtKB/Swiss-Prot
    O55042
    Related
    ENSMUSP00000109907.3, OTTMUSP00000073979, ENSMUST00000114268.4, OTTMUST00000141609
    Conserved Domains (1) summary
    pfam01387
    Location:1110
    Synuclein; Synuclein
  2. NM_009221.2NP_033247.1  alpha-synuclein

    See identical proteins and their annotated locations for NP_033247.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF179273, BC046764
    Consensus CDS
    CCDS20201.1
    UniProtKB/Swiss-Prot
    O55042
    Related
    ENSMUSP00000126067.1, OTTMUSP00000073978, ENSMUST00000163779.7, OTTMUST00000141608
    Conserved Domains (1) summary
    pfam01387
    Location:1110
    Synuclein; Synuclein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

    Range
    60731573..60829855 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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