U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Snapin SNAP-associated protein [ Mus musculus (house mouse) ]

Gene ID: 20615, updated on 8-Dec-2022

Summary

Official Symbol
Snapinprovided by MGI
Official Full Name
SNAP-associated proteinprovided by MGI
Primary source
MGI:MGI:1333745
See related
Ensembl:ENSMUSG00000001018 AllianceGenome:MGI:1333745
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
25kDa; Snapap; Bloc1s7; Snap25bp
Summary
Predicted to enable SNARE binding activity. Involved in anterograde synaptic vesicle transport; negative regulation of neuron projection development; and regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including lysosomal lumen acidification; terminal button organization; and vesicle organization. Located in acrosomal vesicle; cytosol; and manchette. Part of BLOC-1 complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human SNAPIN (SNAP associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 30.5), heart adult (RPKM 20.4) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Snapin in Genome Data Viewer
Location:
3; 3 F1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (90395333..90398320, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (90488026..90491013, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene natriuretic peptide receptor 1 Neighboring gene nuclear encoded tRNA methionine 11 (anticodon CAT) Neighboring gene interleukin enhancer binding factor 2 Neighboring gene chromatin target of PRMT1 Neighboring gene S100 calcium binding protein A1 Neighboring gene S100 calcium binding protein A13

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SNARE binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in anterograde axonal transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in anterograde synaptic vesicle transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within autophagosome maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium-ion regulated exocytosis TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endosome to lysosome transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within establishment of vesicle localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within late endosome to lysosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lysosomal lumen acidification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lysosome localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lysosome localization ISO
Inferred from Sequence Orthology
more info
 
involved_in lysosome localization NAS
Non-traceable Author Statement
more info
PubMed 
involved_in lysosome organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within lysosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in melanosome organization NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of neuron projection development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuron cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in organelle transport along microtubule NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within protein maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein-containing complex localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of endosome size NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of lysosome size NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within retrograde axonal transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within synaptic vesicle fusion to presynaptic active zone membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within synaptic vesicle maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within terminal button organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of BLOC-1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of BLOC-1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of BLOC-1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of BORC complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of BORC complex ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic side of lysosomal membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in manchette IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
SNARE-associated protein Snapin
Names
BLOC-1 subunit 7
biogenesis of lysosome-related organelles complex 1 subunit 7
synaptosomal-associated protein 25 binding protein
synaptosomal-associated protein, 25 kDa, binding protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133854.3NP_598615.1  SNARE-associated protein Snapin

    See identical proteins and their annotated locations for NP_598615.1

    Status: VALIDATED

    Source sequence(s)
    AC160552, AK048007, AK050151
    Consensus CDS
    CCDS17531.1
    UniProtKB/Swiss-Prot
    Q922V7, Q9Z266
    UniProtKB/TrEMBL
    A0A6P5PH28, A0A8C6G706
    Related
    ENSMUSP00000122090.2, ENSMUST00000149884.2
    Conserved Domains (1) summary
    pfam14712
    Location:24110
    Snapin_Pallidin; Snapin/Pallidin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    90395333..90398320 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)