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Snai1 snail family zinc finger 1 [ Mus musculus (house mouse) ]

Gene ID: 20613, updated on 10-Jan-2023

Summary

Official Symbol
Snai1provided by MGI
Official Full Name
snail family zinc finger 1provided by MGI
Primary source
MGI:MGI:98330
See related
Ensembl:ENSMUSG00000042821 AllianceGenome:MGI:98330
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sna; Sna1; Snail; Snail1
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including heart development; positive regulation of epithelial to mesenchymal transition; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; left/right pattern formation; and negative regulation of cell differentiation involved in embryonic placenta development. Located in cytoplasm; nucleus; and pericentric heterochromatin. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; genitourinary system; and sensory organ. Used to study dilated cardiomyopathy and skin cancer. Orthologous to human SNAI1 (snail family transcriptional repressor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 49.3), lung adult (RPKM 33.6) and 20 other tissues See more
Orthologs
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Genomic context

See Snai1 in Genome Data Viewer
Location:
2 H3; 2 87.33 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (167380115..167384734)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (167538195..167542814)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 2 Neighboring gene ring finger protein 114 Neighboring gene predicted gene 11474 Neighboring gene predicted gene 11476 Neighboring gene predicted gene, 31619 Neighboring gene ribosomal protein L18 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in Notch signaling involved in heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cartilage morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within epithelial cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial to mesenchymal transition involved in endocardial cushion formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hair follicle morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in heterochromatin organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within left/right pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mesoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mesoderm formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell differentiation involved in embryonic placenta development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vitamin D biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within roof of mouth development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within trophoblast giant cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in pericentric heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in pericentric heterochromatin ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
zinc finger protein SNAI1
Names
snail homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011427.3NP_035557.1  zinc finger protein SNAI1

    See identical proteins and their annotated locations for NP_035557.1

    Status: VALIDATED

    Source sequence(s)
    AK144478, AL589870, BU756566
    Consensus CDS
    CCDS17102.1
    UniProtKB/Swiss-Prot
    Q02085
    UniProtKB/TrEMBL
    Q4FK48
    Related
    ENSMUSP00000050581.8, ENSMUST00000052631.8
    Conserved Domains (4) summary
    COG5048
    Location:177253
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:182202
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:208230
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:195218
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    167380115..167384734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)