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TRIML2 tripartite motif family like 2 [ Homo sapiens (human) ]

Gene ID: 205860, updated on 4-Jul-2021

Summary

Official Symbol
TRIML2provided by HGNC
Official Full Name
tripartite motif family like 2provided by HGNC
Primary source
HGNC:HGNC:26378
See related
Ensembl:ENSG00000179046
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPRYD6
Summary
This gene encodes a member of the tri-partite motif (TRIM) family of proteins. This protein may be regulated by the tumor suppressor p53 and may regulate p53 through the enhancement of p53 SUMOylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Expression
Biased expression in placenta (RPKM 2.0) and testis (RPKM 1.2) See more
Orthologs
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Genomic context

See TRIML2 in Genome Data Viewer
Location:
4q35.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (188091255..188109603, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (189012426..189030757, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene peroxiredoxin 6 pseudogene Neighboring gene Sharpr-MPRA regulatory region 7889 Neighboring gene ZFP42 zinc finger protein Neighboring gene uncharacterized LOC107986337 Neighboring gene FAU pseudogene 3 Neighboring gene RNA, U6 small nuclear 173, pseudogene Neighboring gene tripartite motif family like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25801, FLJ56315, MGC138164, MGC138166

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of viral entry into host cell IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable E3 ubiquitin-protein ligase TRIML2
Names
RING-type E3 ubiquitin transferase TRIML2
SPRY domain-containing protein 6
tripartite motif family-like protein 2
NP_001290348.1
NP_775824.2
XP_011530039.1
XP_011530040.1
XP_011530041.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303419.1NP_001290348.1  probable E3 ubiquitin-protein ligase TRIML2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA729485, AC108073, AK300428, BC111959, BC143709, DA666390
    UniProtKB/Swiss-Prot
    Q8N7C3
    UniProtKB/TrEMBL
    B7ZLC3
    Related
    ENSP00000317498.4, ENST00000326754.7
    Conserved Domains (1) summary
    cd13733
    Location:276449
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
  2. NM_173553.4NP_775824.2  probable E3 ubiquitin-protein ligase TRIML2 isoform 2

    See identical proteins and their annotated locations for NP_775824.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region compared to variant 1. This results in isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC108073, AK098667, AK300428, BC111959, DA666390, DC382432
    Consensus CDS
    CCDS3850.2
    UniProtKB/Swiss-Prot
    Q8N7C3
    Related
    ENSP00000507413.1, ENST00000682553.1
    Conserved Domains (1) summary
    cd13733
    Location:251424
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    188091255..188109603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531738.2XP_011530040.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X1

    See identical proteins and their annotated locations for XP_011530040.1

    Related
    ENSP00000422581.2, ENST00000512729.5
    Conserved Domains (1) summary
    cd13733
    Location:251424
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
  2. XM_011531737.2XP_011530039.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X1

    See identical proteins and their annotated locations for XP_011530039.1

    Conserved Domains (1) summary
    cd13733
    Location:251424
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
  3. XM_011531739.1XP_011530041.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X2

    Conserved Domains (1) summary
    cd13733
    Location:159332
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

RNA

  1. XR_938704.2 RNA Sequence

  2. XR_938705.2 RNA Sequence

  3. XR_938703.2 RNA Sequence

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