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Slpi secretory leukocyte peptidase inhibitor [ Mus musculus (house mouse) ]

Gene ID: 20568, updated on 18-Apr-2024

Summary

Official Symbol
Slpiprovided by MGI
Official Full Name
secretory leukocyte peptidase inhibitorprovided by MGI
Primary source
MGI:MGI:109297
See related
Ensembl:ENSMUSG00000017002 AllianceGenome:MGI:109297
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ALP
Summary
Enables endopeptidase inhibitor activity. Involved in antibacterial humoral response; innate immune response; and response to lipopolysaccharide. Located in extracellular space. Is expressed in embryo; liver left lobe; liver right lobe; and ureter. Orthologous to human SLPI (secretory leukocyte peptidase inhibitor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 76.0), stomach adult (RPKM 51.1) and 8 other tissues See more
Orthologs
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Genomic context

Location:
2 H3; 2 85.16 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164195990..164231086, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164354070..164356507, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene seminal vesicle secretory protein 6 Neighboring gene seminal vesicle secretory protein 5 Neighboring gene microRNA 7678 Neighboring gene STARR-seq mESC enhancer starr_06324 Neighboring gene matrilin 4 Neighboring gene recombination signal binding protein for immunoglobulin kappa J region-like Neighboring gene STARR-positive B cell enhancer ABC_E6015 Neighboring gene STARR-positive B cell enhancer ABC_E4517 Neighboring gene STARR-positive B cell enhancer ABC_E6016 Neighboring gene STARR-seq mESC enhancer starr_06326 Neighboring gene syndecan 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164266728-164266915

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in antibacterial humoral response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in antibacterial humoral response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in modulation of process of another organism ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
involved_in response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
antileukoproteinase
Names
secretory leukocyte protease inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412601.1NP_001399530.1  antileukoproteinase isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL590429
    UniProtKB/Swiss-Prot
    O09081, O09082, P97430
    UniProtKB/TrEMBL
    Q548X8
  2. NM_001412602.1NP_001399531.1  antileukoproteinase isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL590429
    UniProtKB/Swiss-Prot
    O09081, O09082, P97430
    UniProtKB/TrEMBL
    Q548X8
  3. NM_001412603.1NP_001399532.1  antileukoproteinase isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL590429
  4. NM_011414.4NP_035544.1  antileukoproteinase isoform 1 precursor

    See identical proteins and their annotated locations for NP_035544.1

    Status: VALIDATED

    Source sequence(s)
    AL590429
    Consensus CDS
    CCDS17033.1
    UniProtKB/Swiss-Prot
    O09081, O09082, P97430
    UniProtKB/TrEMBL
    Q548X8
    Related
    ENSMUSP00000104992.4, ENSMUST00000109367.10
    Conserved Domains (2) summary
    smart00217
    Location:86131
    WAP; Four-disulfide core domains
    pfam00095
    Location:3276
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

RNA

  1. NR_182003.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL590429

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    164195990..164231086 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)