Slpi secretory leukocyte peptidase inhibitor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slpiprovided by MGI
Official Full Name: secretory leukocyte peptidase inhibitorprovided by MGI
Primary source: MGI:MGI:109297
See related: Ensembl:ENSMUSG00000017002 AllianceGenome:MGI:109297
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ALP
Summary: Enables endopeptidase inhibitor activity. Involved in antibacterial humoral response; innate immune response; and response to lipopolysaccharide. Located in extracellular space. Is expressed in embryo; liver left lobe; liver right lobe; and ureter. Orthologous to human SLPI (secretory leukocyte peptidase inhibitor). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in lung adult (RPKM 76.0), stomach adult (RPKM 51.1) and 8 other tissues See more
Orthologs: all
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Genomic context

Location:: 2 H3; 2 85.16 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (164195990..164231086, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (164354070..164356507, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Secretory leukocyte protease inhibitor protects against severe urinary tract infection in mice.
Title: Secretory leukocyte protease inhibitor protects against severe urinary tract infection in mice.
Protease inhibitory activity of secretory leukocyte protease inhibitor ameliorates murine experimental colitis by protecting the intestinal epithelial barrier.
Title: Protease inhibitory activity of secretory leukocyte protease inhibitor ameliorates murine experimental colitis by protecting the intestinal epithelial barrier.
Overexpression of secretory leukocyte peptidase inhibitor (SLPI) does not modulate experimental osteoarthritis but may be a biomarker for the disease.
Title: Overexpression of secretory leukocyte peptidase inhibitor (SLPI) does not modulate experimental osteoarthritis but may be a biomarker for the disease.
Secretory leukocyte protease inhibitor and progranulin as possible regulators of cervical remodeling in pregnancy.
Title: Secretory leukocyte protease inhibitor and progranulin as possible regulators of cervical remodeling in pregnancy.
SLPI is a critical mediator that controls PTH-induced bone formation.
Title: SLPI is a critical mediator that controls PTH-induced bone formation.
Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation.
Title: Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation.
Mecp2 Upregulates Slpi to Reduce Obesity by Enhancing Browning of adipocytes. This is a novel non-central nervous system function of Mecp2 in obesity by suppressing browning, at least partially, through regulating adipokine Slpi.
Title: Fat-Specific Knockout of Mecp2 Upregulates Slpi to Reduce Obesity by Enhancing Browning.
we propose a novel anti-inflammatory mechanism induced by SLPI, which inhibits the ATP-dependent maturation and secretion of IL-1beta.
Title: SLPI Inhibits ATP-Mediated Maturation of IL-1β in Human Monocytic Leukocytes: A Novel Function of an Old Player.
We demonstrate by silencing the SLPI gene, that SLPI negatively regulates human periodontal ligament cell expression of the pro-inflammatory cytokines IL-6 and MCP-1.
Title: Secretory leukocyte protease inhibitor regulates human periodontal ligament cell production of pro-inflammatory cytokines.
MIF-2/D-DT is an early response cytokine in the I/R injury repair of the proximal tubule, enhancing regeneration through SLPI- and ATF4-dependent mechanisms.
Title: MIF-2/D-DT enhances proximal tubular cell regeneration through SLPI- and ATF4-dependent mechanisms.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slpi (e-PCR), detects polymorphism
- UniSTS:545872

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IBA Inferred from Biological aspect of Ancestor more info
involved_in antibacterial humoral response	IEA Inferred from Electronic Annotation more info
involved_in antibacterial humoral response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antibacterial humoral response	ISO Inferred from Sequence Orthology more info
involved_in host-mediated perturbation of symbiont process	IEA Inferred from Electronic Annotation more info
involved_in host-mediated perturbation of symbiont process	ISO Inferred from Sequence Orthology more info
involved_in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of viral genome replication	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in extracellular region	EXP Inferred from Experiment more info	PubMed
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: antileukoproteinase

Names: secretory leukocyte protease inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001412601.1 → NP_001399530.1 antileukoproteinase isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL590429

UniProtKB/Swiss-Prot

O09081, O09082, P97430

UniProtKB/TrEMBL

Q548X8
NM_001412602.1 → NP_001399531.1 antileukoproteinase isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL590429

UniProtKB/Swiss-Prot

O09081, O09082, P97430

UniProtKB/TrEMBL

Q548X8
NM_001412603.1 → NP_001399532.1 antileukoproteinase isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AL590429
NM_011414.4 → NP_035544.1 antileukoproteinase isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL590429

Consensus CDS

CCDS17033.1

UniProtKB/Swiss-Prot

O09081, O09082, P97430

UniProtKB/TrEMBL

Q548X8

Related

ENSMUSP00000104992.4, ENSMUST00000109367.10

Conserved Domains (2) summary

smart00217
Location:86 → 131

WAP; Four-disulfide core domains

pfam00095
Location:32 → 76

WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'