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SENP5 SUMO specific peptidase 5 [ Homo sapiens (human) ]

Gene ID: 205564, updated on 23-Nov-2021

Summary

Official Symbol
SENP5provided by HGNC
Official Full Name
SUMO specific peptidase 5provided by HGNC
Primary source
HGNC:HGNC:28407
See related
Ensembl:ENSG00000119231 MIM:612845
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
Expression
Ubiquitous expression in testis (RPKM 8.4), brain (RPKM 6.3) and 25 other tissues See more
Orthologs
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Genomic context

See SENP5 in Genome Data Viewer
Location:
3q29
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (196867897..196934714)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (196594791..196661585)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, U4 small nuclear 89, pseudogene Neighboring gene p21 (RAC1) activated kinase 2 Neighboring gene RNA, U6 small nuclear 42, pseudogene Neighboring gene NCBP2 antisense RNA 1 Neighboring gene NCBP2 antisense 2 (head to head) Neighboring gene nuclear cap binding protein subunit 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of SUMO1/sentrin specific peptidase 5 (SENP5) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ42398, MGC27076, DKFZp564O1016

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SUMO-specific endopeptidase activity EXP
Inferred from Experiment
more info
PubMed 
enables SUMO-specific protease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in protein desumoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
sentrin-specific protease 5
Names
SUMO1/sentrin specific peptidase 5
SUMO1/sentrin specific protease 5
sentrin/SUMO-specific protease SENP5
NP_001294974.1
NP_689912.2
XP_005269367.1
XP_011510846.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308045.2NP_001294974.1  sentrin-specific protease 5 isoform 2

    See identical proteins and their annotated locations for NP_001294974.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC011322, AK302305, AK313764, AL049229
    Consensus CDS
    CCDS77876.1
    UniProtKB/Swiss-Prot
    Q96HI0
    UniProtKB/TrEMBL
    B2R9F5
    Related
    ENSP00000390231.2, ENST00000445299.6
    Conserved Domains (1) summary
    cl23802
    Location:581707
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  2. NM_152699.5NP_689912.2  sentrin-specific protease 5 isoform 1

    See identical proteins and their annotated locations for NP_689912.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC011322, AL049229, BC030705, DC399261
    Consensus CDS
    CCDS3322.1
    UniProtKB/Swiss-Prot
    Q96HI0
    Related
    ENSP00000327197.5, ENST00000323460.10
    Conserved Domains (1) summary
    pfam02902
    Location:581753
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    196867897..196934714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512544.3XP_011510846.1  sentrin-specific protease 5 isoform X1

    See identical proteins and their annotated locations for XP_011510846.1

    UniProtKB/Swiss-Prot
    Q96HI0
    Conserved Domains (1) summary
    pfam02902
    Location:581753
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  2. XM_005269310.3XP_005269367.1  sentrin-specific protease 5 isoform X2

    Conserved Domains (1) summary
    pfam02902
    Location:581725
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
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