Format

Send to:

Choose Destination

Slc9a1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 [ Mus musculus (house mouse) ]

Gene ID: 20544, updated on 30-Mar-2019

Summary

Official Symbol
Slc9a1provided by MGI
Official Full Name
solute carrier family 9 (sodium/hydrogen exchanger), member 1provided by MGI
Primary source
MGI:MGI:102462
See related
Ensembl:ENSMUSG00000028854
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
swe; Apnh; Nhe1; Mir5122; AW554487; mir-5122
Expression
Ubiquitous expression in stomach adult (RPKM 66.6), adrenal adult (RPKM 34.2) and 25 other tissues See more
Orthologs

Genomic context

See Slc9a1 in Genome Data Viewer
Location:
4 D2.3; 4 66.25 cM
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (133369711..133423702)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (132925687..132979613)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene transmembrane protein 222 Neighboring gene WD and tetratricopeptide repeats 1 Neighboring gene microRNA 5122 Neighboring gene RIKEN cDNA 1700091J24 gene Neighboring gene predicted gene, 42322

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
antiporter activity IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
potassium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase 2B binding ISO
Inferred from Sequence Orthology
more info
 
sodium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium:proton antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
sodium:proton antiporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
sodium:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
 
solute:proton antiporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cardiac muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cation transport IEA
Inferred from Electronic Annotation
more info
 
cellular response to acidic pH ISO
Inferred from Sequence Orthology
more info
 
cellular response to epinephrine stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular sodium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
ion transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
neuron death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of action potential ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of calcium:sodium antiporter activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitochondrial membrane permeability ISO
Inferred from Sequence Orthology
more info
 
positive regulation of the force of heart contraction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proton transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
regulation of cardiac muscle contraction by calcium ion signaling ISO
Inferred from Sequence Orthology
more info
 
regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of intracellular pH ISO
Inferred from Sequence Orthology
more info
 
regulation of pH IDA
Inferred from Direct Assay
more info
PubMed 
regulation of pH IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of pH ISO
Inferred from Sequence Orthology
more info
 
regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
regulation of the force of heart contraction ISO
Inferred from Sequence Orthology
more info
 
regulation of the force of heart contraction by cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
response to acidic pH IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to acidic pH ISO
Inferred from Sequence Orthology
more info
 
response to muscle stretch ISO
Inferred from Sequence Orthology
more info
 
response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
sodium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
sodium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
T-tubule ISO
Inferred from Sequence Orthology
more info
 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
basolateral plasma membrane TAS
Traceable Author Statement
more info
PubMed 
cation-transporting ATPase complex ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
intercalated disc ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
sarcolemma ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sodium/hydrogen exchanger 1
Names
NHE-1
Na(+)/H(+) exchanger 1
Na+/H+ antiporter
Na+/H+, amiloride sensitive
slow-wave epilepsy
solute carrier family 9, member 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358455.1NP_001345384.1  sodium/hydrogen exchanger 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK150135, AK165501, AL671882, BQ771297, BU056477, CO041694
    Conserved Domains (1) summary
    cl25615
    Location:1321
    NhaP2; NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism]
  2. NM_016981.3NP_058677.1  sodium/hydrogen exchanger 1 isoform 1

    See identical proteins and their annotated locations for NP_058677.1

    Status: VALIDATED

    Source sequence(s)
    AK150135, AK165501, AL671882, BU056477, CO041694
    Consensus CDS
    CCDS38903.1
    UniProtKB/Swiss-Prot
    Q61165
    UniProtKB/TrEMBL
    Q3TN68, Q3UDC9
    Related
    ENSMUSP00000030669.7, ENSMUST00000030669.7
    Conserved Domains (3) summary
    TIGR00840
    Location:99664
    b_cpa1; sodium/hydrogen exchanger 3
    pfam00999
    Location:109507
    Na_H_Exchanger; Sodium/hydrogen exchanger family
    pfam16644
    Location:606704
    NEXCaM_BD; Regulatory region of Na+/H+ exchanger NHE binds to calmodulin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

    Range
    133369711..133423702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538687.2XP_006538750.1  sodium/hydrogen exchanger 1 isoform X2

    Conserved Domains (1) summary
    cl25615
    Location:1321
    NhaP2; NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism]
  2. XM_017320089.1XP_017175578.1  sodium/hydrogen exchanger 1 isoform X2

    Conserved Domains (1) summary
    cl25615
    Location:1321
    NhaP2; NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism]
  3. XM_006538686.3XP_006538749.1  sodium/hydrogen exchanger 1 isoform X1

    Conserved Domains (3) summary
    TIGR00840
    Location:25566
    b_cpa1; sodium/hydrogen exchanger 3
    pfam00999
    Location:35409
    Na_H_Exchanger; Sodium/hydrogen exchanger family
    pfam16644
    Location:508606
    NEXCaM_BD; Regulatory region of Na+/H+ exchanger NHE binds to calmodulin
Support Center