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DIPK2A divergent protein kinase domain 2A [ Homo sapiens (human) ]

Gene ID: 205428, updated on 17-Sep-2024

Summary

Official Symbol
DIPK2Aprovided by HGNC
Official Full Name
divergent protein kinase domain 2Aprovided by HGNC
Primary source
HGNC:HGNC:28490
See related
Ensembl:ENSG00000181744 MIM:612200; AllianceGenome:HGNC:28490
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIA1; HASF; C3orf58; GoPro49
Summary
Involved in several processes, including cardiac muscle cell proliferation; negative regulation of smooth muscle cell apoptotic process; and positive regulation of protein kinase C activity. Located in Golgi membrane and extracellular space. Part of COPI vesicle coat. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta (RPKM 13.9), bone marrow (RPKM 9.8) and 24 other tissues See more
Orthologs
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Genomic context

See DIPK2A in Genome Data Viewer
Location:
3q24
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (143971798..143992368)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (146718429..146738995)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (143690640..143711210)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 9 member A9 Neighboring gene uncharacterized LOC102724120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:143366803-143367304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:143367305-143367804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20657 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20658 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20659 Neighboring gene ribosomal protein S17 pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20660 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14800 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20663 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:143690552-143691132 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:143689971-143690551 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20664 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20665 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:143856144-143856657 Neighboring gene uncharacterized LOC105374140 Neighboring gene RNA, 5S ribosomal pseudogene 144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20667 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20669 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20670 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:144156282-144157481

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
divergent protein kinase domain 2A
Names
Golgi Protein of 49 kDa
Golgi protein GoPro49
UPF0672 protein C3orf58
deleted in autism 1
deleted in autism protein 1
hypoxia and AKT-induced stem cell factor
hypoxia and Akt induced stem cell factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134470.2NP_001127942.1  divergent protein kinase domain 2A isoform b

    See identical proteins and their annotated locations for NP_001127942.1

    Status: VALIDATED

    Source sequence(s)
    AK095400, BC037293, BM968874, DC310234, DC310421, DC323688
    Consensus CDS
    CCDS46929.1
    UniProtKB/TrEMBL
    B3KTD4
    Related
    ENSP00000417382.1, ENST00000495414.5
    Conserved Domains (1) summary
    pfam12260
    Location:11196
    PIP49_C; Protein-kinase domain of FAM69
  2. NM_001363944.1NP_001350873.1  divergent protein kinase domain 2A isoform c

    Status: VALIDATED

    Source sequence(s)
    AC117379
    Consensus CDS
    CCDS87151.1
    UniProtKB/TrEMBL
    B3KTD4, E7ET39
    Related
    ENSP00000390796.2, ENST00000441925.2
    Conserved Domains (1) summary
    pfam12260
    Location:1167
    PIP49_C; Protein-kinase domain of FAM69
  3. NM_173552.5NP_775823.1  divergent protein kinase domain 2A isoform a precursor

    See identical proteins and their annotated locations for NP_775823.1

    Status: VALIDATED

    Source sequence(s)
    AK095400, BC037293, BM968874, DA760601, DB067725
    Consensus CDS
    CCDS3130.1
    UniProtKB/Swiss-Prot
    B2RCF2, B7Z1W3, Q8NDZ4
    Related
    ENSP00000320081.4, ENST00000315691.8
    Conserved Domains (1) summary
    pfam12260
    Location:206405
    PIP49_C; Protein-kinase domain of FAM69

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    143971798..143992368
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512543.3XP_011510845.1  divergent protein kinase domain 2A isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    146718429..146738995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345657.1XP_054201632.1  divergent protein kinase domain 2A isoform X1