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Slc4a2 solute carrier family 4 (anion exchanger), member 2 [ Mus musculus (house mouse) ]

Gene ID: 20535, updated on 22-Jan-2023

Summary

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Official Symbol
Slc4a2provided by MGI
Official Full Name
solute carrier family 4 (anion exchanger), member 2provided by MGI
Primary source
MGI:MGI:109351
See related
Ensembl:ENSMUSG00000028962 AllianceGenome:MGI:109351
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ae2; B3RP
Summary
Enables chloride transmembrane transporter activity. Involved in amelogenesis; chloride transport; and positive regulation of enamel mineralization. Located in basolateral plasma membrane. Is expressed in brain and cornea. Orthologous to human SLC4A2 (solute carrier family 4 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in stomach adult (RPKM 54.7), colon adult (RPKM 48.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Slc4a2 in Genome Data Viewer
Location:
5 A3; 5 11.74 cM
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (24628939..24645945)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (24423761..24440947)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 8 Neighboring gene cyclin-dependent kinase 5 Neighboring gene acid-sensing (proton-gated) ion channel 3 Neighboring gene U6 spliceosomal RNA Neighboring gene Fas-activated serine/threonine kinase Neighboring gene transmembrane and ubiquitin-like domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hydrophobic bile acids suppress expression of AE2 in biliary epithelial cells and induce bile duct inflammation in primary biliary cholangitis. Hisamoto S, et al. J Autoimmun, 2016 Dec. PMID 27592379
  2. Anion exchanger 2 is critical for CD8(+) T cells to maintain pHi homeostasis and modulate immune responses. Concepcion AR, et al. Eur J Immunol, 2014 May. PMID 24515893
  3. AE2 Cl-/HCO3- exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon. Gawenis LR, et al. Am J Physiol Gastrointest Liver Physiol, 2010 Apr. PMID 20110461, Free PMC Article
  4. HCO3(-)/Cl(-) exchange inactivation and reactivation during mouse oocyte meiosis correlates with MEK/MAPK-regulated Ae2 plasma membrane localization. Zhou C, et al. PLoS One, 2009 Oct 12. PMID 19823673, Free PMC Article
  5. Ae2(a,b)-deficient mice exhibit osteopetrosis of long bones but not of calvaria. Jansen ID, et al. FASEB J, 2009 Oct. PMID 19564250

See all (78) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLC4A2, another gene involved in acid-base balancing machinery of osteoclasts, causes osteopetrosis.
    Title: SLC4A2, another gene involved in acid-base balancing machinery of osteoclasts, causes osteopetrosis.
  2. Both IRBIT and long-IRBIT bind to and coordinately regulate Cl(-)/HCO3(-) exchanger AE2 activity through modulating the lysosomal degradation of AE2.
    Title: Both IRBIT and long-IRBIT bind to and coordinately regulate Cl(-)/HCO(3)(-) exchanger AE2 activity through modulating the lysosomal degradation of AE2.
  3. results strongly suggest that Ae2 is a critical factor in the innate response to C. albicans. This study represents an important contribution to a better understanding of how Dectin-1 expression and fungal clearance is regulated.
    Title: Anion Exchanger 2 Regulates Dectin-1-Dependent Phagocytosis and Killing of Candida albicans.
  4. Data indicate a key functional role of anion exchanger 2 (AE2) in the maintenance of the normal physiology of biliary epithelial cells (BEC) and the pathogenic consequences of reduced AE2 expression, including abnormal intrinsic characteristics of BEC and their production of signal molecules that lead to the chronic inflammatory responses in small bile ducts.
    Title: Hydrophobic bile acids suppress expression of AE2 in biliary epithelial cells and induce bile duct inflammation in primary biliary cholangitis.
  5. AE2 deficiency results in intrahepatic T-cell activation and PD-1/PD-L1 mediated deletion, favoring autoimmune cholangitis.
    Title: CD8+ T cells undergo activation and programmed death-1 repression in the liver of aged Ae2a,b-/- mice favoring autoimmune cholangitis.
  6. GnRH neurons were immunopositive for NKCC1 and AE2.
    Title: Chloride Accumulators NKCC1 and AE2 in Mouse GnRH Neurons: Implications for GABAA Mediated Excitation.
  7. These findings demonstrate that CD8(+) T cells are critically dependent on Ae2 for pHi homeostasis and tuning of cell proliferation and activation. Ae2 thus constitutes a novel target to modulate CD8(+) T-cell responses.
    Title: Anion exchanger 2 is critical for CD8(+) T cells to maintain pHi homeostasis and modulate immune responses.
  8. Rescue of SLC4A2-deficient osteoclasts with functionally defined mutants of SLC4A2 indicates regulation of actin cytoskeletal reorganization by anion-exchange activity and intracellular pH, independent of SLC4A2's long N-terminal cytoplasmic domain.
    Title: SLC4A2-mediated Cl-/HCO3- exchange activity is essential for calpain-dependent regulation of the actin cytoskeleton in osteoclasts.
  9. expression of Slc4a2 significantly decreased in enamel organs from Mmp20(-/-) mice. A feedback mechanism regulates ion-responsive gene expression during enamel development.
    Title: Altered ion-responsive gene expression in Mmp20 null mice.
  10. AE2 is a component of the basolateral ion transport mechanisms that support anion secretion in the proximal colon.
    Title: AE2 Cl-/HCO3- exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables chloride transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables chloride:bicarbonate antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables chloride:bicarbonate antiporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables chloride:bicarbonate antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic anion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables solute:inorganic anion antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in amelogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in bicarbonate transport IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in chloride transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic anion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of CD8-positive, alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of CD8-positive, alpha-beta T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of enamel mineralization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of bone resorption IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of intracellular pH ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
anion exchange protein 2
Names
AE 2
anion exchanger 2 type b1
anion exchanger 2 type b2
anion exchanger 2 type c1
anion exchanger 2 type c2
band 3-related protein
non-erythroid band 3-like protein
solute carrier family 4 member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253892.1 → NP_001240821.1  anion exchange protein 2

    See identical proteins and their annotated locations for NP_001240821.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK145930, BC054102
    Consensus CDS
    CCDS19119.1
    UniProtKB/Swiss-Prot
    P13808
    UniProtKB/TrEMBL
    A0A0R4J101, Q3UKP0, Q7TPS4
    Conserved Domains (2) summary
    PTZ00449
    Location:3 → 321
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    TIGR00834
    Location:320 → 1236
    ae; anion exchange protein

  2. NM_009207.3 → NP_033233.2  anion exchange protein 2

    See identical proteins and their annotated locations for NP_033233.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    AK145930, BC054102, CJ110714
    Consensus CDS
    CCDS19119.1
    UniProtKB/Swiss-Prot
    P13808
    UniProtKB/TrEMBL
    A0A0R4J101, Q3UKP0, Q7TPS4
    Related
    ENSMUSP00000078972.7, ENSMUST00000080067.13
    Conserved Domains (2) summary
    PTZ00449
    Location:3 → 321
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    TIGR00834
    Location:320 → 1236
    ae; anion exchange protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    24628939..24645945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535650.2 → XP_006535713.1  anion exchange protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006535713.1

    UniProtKB/Swiss-Prot
    P13808
    UniProtKB/TrEMBL
    A0A0R4J101
    Conserved Domains (2) summary
    PTZ00449
    Location:3 → 321
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    TIGR00834
    Location:320 → 1236
    ae; anion exchange protein

  2. XM_006535651.5 → XP_006535714.1  anion exchange protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006535714.1

    UniProtKB/Swiss-Prot
    P13808
    UniProtKB/TrEMBL
    A0A0R4J101
    Conserved Domains (2) summary
    PTZ00449
    Location:3 → 321
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    TIGR00834
    Location:320 → 1236
    ae; anion exchange protein

  3. XM_006535653.1 → XP_006535716.1  anion exchange protein 2 isoform X2

    Conserved Domains (2) summary
    PTZ00449
    Location:3 → 321
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    TIGR00834
    Location:320 → 1232
    ae; anion exchange protein

  4. XM_006535655.5 → XP_006535718.1  anion exchange protein 2 isoform X4

    See identical proteins and their annotated locations for XP_006535718.1

    UniProtKB/Swiss-Prot
    P13808
    UniProtKB/TrEMBL
    A0A0R4J1K9
    Related
    ENSMUSP00000110701.3, ENSMUST00000115049.9
    Conserved Domains (2) summary
    PRK07764
    Location:80 → 189
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    TIGR00834
    Location:311 → 1227
    ae; anion exchange protein

  5. XM_036164938.1 → XP_036020831.1  anion exchange protein 2 isoform X3

  6. XM_006535656.4 → XP_006535719.1  anion exchange protein 2 isoform X5

    See identical proteins and their annotated locations for XP_006535719.1

    UniProtKB/Swiss-Prot
    P13808
    UniProtKB/TrEMBL
    A0A0R4J1K4
    Related
    ENSMUSP00000110699.3, ENSMUST00000115047.3
    Conserved Domains (2) summary
    PRK07764
    Location:75 → 184
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    TIGR00834
    Location:306 → 1222
    ae; anion exchange protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13808.1 GenPept UniProtKB/Swiss-Prot:P13808

Gene LinkOut

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