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Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 [ Mus musculus (house mouse) ]

Gene ID: 20526, updated on 8-Oct-2024

Summary

Official Symbol
Slc2a2provided by MGI
Official Full Name
solute carrier family 2 (facilitated glucose transporter), member 2provided by MGI
Primary source
MGI:MGI:1095438
See related
Ensembl:ENSMUSG00000027690 AllianceGenome:MGI:1095438
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Glut2; Glut-2
Summary
Enables D-glucose transmembrane transporter activity and dehydroascorbic acid transmembrane transporter activity. Involved in dehydroascorbic acid transport and glucose transmembrane transport. Located in several cellular components, including apical plasma membrane; brush border; and cell-cell junction. Is expressed in several structures, including alimentary system; early conceptus; liver; metanephros; and testis. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Fanconi syndrome; glycogen storage disease; and type 2 diabetes mellitus. Orthologous to human SLC2A2 (solute carrier family 2 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 50.7), liver E18 (RPKM 37.6) and 7 other tissues See more
Orthologs
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Genomic context

See Slc2a2 in Genome Data Viewer
Location:
3 A3; 3 12.19 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (28752052..28782510)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (28697903..28728361)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene TRAF2 and NCK interacting kinase Neighboring gene microRNA 466q Neighboring gene VISTA enhancer mm492 Neighboring gene STARR-seq mESC enhancer starr_07263 Neighboring gene STARR-seq mESC enhancer starr_07264 Neighboring gene STARR-seq mESC enhancer starr_07265 Neighboring gene RIKEN cDNA 1700112D23 gene Neighboring gene predicted gene, 52603 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:28679958-28680067 Neighboring gene predicted pseudogene 6505 Neighboring gene eukaryotic translation initiation factor 5A2 Neighboring gene predicted gene, 32950

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (3) 
  • Targeted (6)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in D-glucose import IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in D-glucose transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in D-glucose transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within carbohydrate transport TAS
Traceable Author Statement
more info
 
involved_in carbohydrate utilization ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to fatty acid ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
involved_in dehydroascorbic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in dehydroascorbic acid transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dehydroascorbic acid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in fructose transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in fructose transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in galactose transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in galactose transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in brush border IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in brush border IDA
Inferred from Direct Assay
more info
 
located_in brush border ISO
Inferred from Sequence Orthology
more info
 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier family 2, facilitated glucose transporter member 2
Names
glucose transporter type 2, liver
liver-type glucose transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031197.2NP_112474.2  solute carrier family 2, facilitated glucose transporter member 2

    See identical proteins and their annotated locations for NP_112474.2

    Status: VALIDATED

    Source sequence(s)
    AI120520, AK005068, AK165430
    Consensus CDS
    CCDS50880.1
    UniProtKB/Swiss-Prot
    P14246, Q3TNA5, Q9DBA7
    Related
    ENSMUSP00000029240.8, ENSMUST00000029240.14
    Conserved Domains (2) summary
    cd06174
    Location:90484
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:14498
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    28752052..28782510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)