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Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 [ Mus musculus (house mouse) ]

Gene ID: 20526, updated on 5-Jan-2022

Summary

Official Symbol
Slc2a2provided by MGI
Official Full Name
solute carrier family 2 (facilitated glucose transporter), member 2provided by MGI
Primary source
MGI:MGI:1095438
See related
Ensembl:ENSMUSG00000027690
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Glut2; Glut-2; AI266973
Summary
Enables D-glucose transmembrane transporter activity and dehydroascorbic acid transmembrane transporter activity. Involved in dehydroascorbic acid transport and glucose transmembrane transport. Located in several cellular components, including apical plasma membrane; brush border; and cell-cell junction. Is expressed in several structures, including alimentary system; early conceptus; liver; metanephros; and testis. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Fanconi syndrome; glycogen storage disease; and type 2 diabetes mellitus. Orthologous to human SLC2A2 (solute carrier family 2 member 2). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in liver adult (RPKM 50.7), liver E18 (RPKM 37.6) and 7 other tissues See more
Orthologs
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Genomic context

See Slc2a2 in Genome Data Viewer
Location:
3 A3; 3 12.19 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (28752052..28782510)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (28697903..28728361)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (28596825..28627283)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene TRAF2 and NCK interacting kinase Neighboring gene VISTA enhancer mm492 Neighboring gene RIKEN cDNA 1700112D23 gene Neighboring gene predicted gene, 52603 Neighboring gene predicted pseudogene 6505 Neighboring gene eukaryotic translation initiation factor 5A2 Neighboring gene predicted gene, 32950

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Chemically induced (ENU) (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate transport TAS
Traceable Author Statement
more info
 
involved_in carbohydrate utilization ISO
Inferred from Sequence Orthology
more info
 
involved_in dehydroascorbic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dehydroascorbic acid transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dehydroascorbic acid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in fructose transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose import IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glucose transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glucose transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in monosaccharide transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in brush border IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in brush border IDA
Inferred from Direct Assay
more info
 
located_in brush border ISO
Inferred from Sequence Orthology
more info
 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier family 2, facilitated glucose transporter member 2
Names
glucose transporter type 2, liver
liver-type glucose transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031197.2NP_112474.2  solute carrier family 2, facilitated glucose transporter member 2

    See identical proteins and their annotated locations for NP_112474.2

    Status: VALIDATED

    Source sequence(s)
    AI120520, AK005068, AK165430
    Consensus CDS
    CCDS50880.1
    UniProtKB/Swiss-Prot
    P14246
    Related
    ENSMUSP00000029240.8, ENSMUST00000029240.14
    Conserved Domains (2) summary
    cd06174
    Location:90484
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:14498
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    28752052..28782510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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