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MTLN mitoregulin [ Homo sapiens (human) ]

Gene ID: 205251, updated on 17-Sep-2024

Summary

Official Symbol
MTLNprovided by HGNC
Official Full Name
mitoregulinprovided by HGNC
Primary source
HGNC:HGNC:27339
See related
Ensembl:ENSG00000175701 MIM:620770; AllianceGenome:HGNC:27339
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MPM; LEMP; MOXI; TILR; SMIM37; LINC00116; NCRNA00116
Summary
Involved in several processes, including fatty acid beta-oxidation; positive regulation of mitochondrial membrane potential; and triglyceride homeostasis. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in fat (RPKM 3.7), kidney (RPKM 3.7) and 25 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See MTLN in Genome Data Viewer
Location:
2q13
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (110211529..110212547, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (110581192..110582210)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (110969106..110970124, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene microRNA 4436b-1 Neighboring gene mal, T cell differentiation protein like Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:110863055-110864254 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:110872579-110873386 Neighboring gene nephrocystin 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:110906815-110908014 Neighboring gene NANOG hESC enhancer GRCh37_chr2:110925133-110925634 Neighboring gene ACTR1A pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16369 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16370 Neighboring gene uncharacterized LOC124906059 Neighboring gene two pore channel 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular respiration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of fatty acid beta-oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of mitochondrial membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of mitochondrial membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein-containing complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of sequestering of calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of sequestering of calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in striated muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
mitoregulin
Names
TP53-inhibiting lncRNA
lncRNA encoded micropeptide
long intergenic non-protein coding RNA 116
micropeptide in mitochondria
micropeptide regulator of beta-oxidation
small integral membrane protein 37

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384134.1NP_001371063.1  mitoregulin

    Status: VALIDATED

    Source sequence(s)
    AC140479
    Consensus CDS
    CCDS92837.1
    UniProtKB/Swiss-Prot
    Q8NCU8
    Related
    ENSP00000485064.1, ENST00000611969.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    110211529..110212547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    110581192..110582210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001355251.2: Suppressed sequence

    Description
    NM_001355251.2: This RefSeq was removed because currently there is not sufficient data to support this transcript.
  2. NM_174925.1: Suppressed sequence

    Description
    NM_174925.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
  3. NR_027063.1: Suppressed sequence

    Description
    NR_027063.1: This RefSeq has been removed because it is now thought that this gene encodes a protein.