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Slc22a2 solute carrier family 22 (organic cation transporter), member 2 [ Mus musculus (house mouse) ]

Gene ID: 20518, updated on 27-Nov-2024

Summary

Official Symbol
Slc22a2provided by MGI
Official Full Name
solute carrier family 22 (organic cation transporter), member 2provided by MGI
Primary source
MGI:MGI:1335072
See related
Ensembl:ENSMUSG00000040966 AllianceGenome:MGI:1335072
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Oct2; Orct2; mOCT2
Summary
Enables several functions, including pyrimidine nucleoside transmembrane transporter activity; toxin transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in cellular detoxification and xenobiotic transport. Acts upstream of or within monoatomic cation transport. Located in apical plasma membrane. Is expressed in several structures, including metanephros; nasal cavity mucosa; nervous system; placenta; and ureter. Human ortholog(s) of this gene implicated in acute kidney failure. Orthologous to human SLC22A2 (solute carrier family 22 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in kidney adult (RPKM 64.5), liver adult (RPKM 7.4) and 1 other tissue See more
Orthologs
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Genomic context

See Slc22a2 in Genome Data Viewer
Location:
17 A1; 17 8.61 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (12803076..12847376)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (12584189..12628489)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 (organic cation transporter), member 3 Neighboring gene RIKEN cDNA C030013G03 gene Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41857 Neighboring gene solute carrier family 22 (organic cation transporter), member 1 Neighboring gene insulin-like growth factor 2 receptor Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:12938713-12938996 Neighboring gene antisense Igf2r RNA

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

General gene information

Markers

Clone Names

  • MGC18339

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables L-arginine transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables L-arginine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables acetylcholine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables acetylcholine transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables amine transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables amine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables choline transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables choline transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables efflux transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables efflux transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables monoamine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables monoamine transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables neurotransmitter transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables neurotransmitter transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables organic anion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables organic cation transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables organic cation transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables organic cation transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables prostaglandin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables prostaglandin transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables putrescine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables putrescine transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables pyrimidine nucleoside transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables pyrimidine nucleoside transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables quaternary ammonium group transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables quaternary ammonium group transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables steroid binding ISO
Inferred from Sequence Orthology
more info
 
enables thiamine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables thiamine transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables toxin transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables toxin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables xenobiotic transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables xenobiotic transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables xenobiotic transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in L-alpha-amino acid transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in L-arginine import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in L-arginine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in L-arginine transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in acetylcholine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in acetylcholine transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in amine transport IEA
Inferred from Electronic Annotation
more info
 
involved_in amine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in amino acid import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular detoxification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular detoxification ISO
Inferred from Sequence Orthology
more info
 
involved_in choline transport IEA
Inferred from Electronic Annotation
more info
 
involved_in choline transport ISO
Inferred from Sequence Orthology
more info
 
involved_in dopamine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in dopamine transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in dopamine uptake IEA
Inferred from Electronic Annotation
more info
 
involved_in dopamine uptake ISO
Inferred from Sequence Orthology
more info
 
involved_in epinephrine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in epinephrine transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in export across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in histamine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in histamine transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in histamine uptake IEA
Inferred from Electronic Annotation
more info
 
involved_in histamine uptake ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic cation transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neurotransmitter transport ISO
Inferred from Sequence Orthology
more info
 
involved_in norepinephrine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in norepinephrine transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in norepinephrine uptake IEA
Inferred from Electronic Annotation
more info
 
involved_in norepinephrine uptake ISO
Inferred from Sequence Orthology
more info
 
involved_in organic cation transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within organic cation transport ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in organic cation transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in prostaglandin transport ISO
Inferred from Sequence Orthology
more info
 
involved_in prostaglandin transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in putrescine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in putrescine transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in quaternary ammonium group transport IEA
Inferred from Electronic Annotation
more info
 
involved_in quaternary ammonium group transport ISO
Inferred from Sequence Orthology
more info
 
involved_in serotonin transport ISO
Inferred from Sequence Orthology
more info
 
involved_in serotonin transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in serotonin uptake IEA
Inferred from Electronic Annotation
more info
 
involved_in serotonin uptake ISO
Inferred from Sequence Orthology
more info
 
involved_in thiamine transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in thiamine transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in xenobiotic transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in xenobiotic transport ISO
Inferred from Sequence Orthology
more info
 
involved_in xenobiotic transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basal plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cholinergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
solute carrier family 22 member 2
Names
organic cation transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355767.1NP_001342696.1  solute carrier family 22 member 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC167817, AK052658, AK143892
    Consensus CDS
    CCDS88992.1
    Related
    ENSMUSP00000156710.2, ENSMUST00000233066.2
    Conserved Domains (1) summary
    TIGR00898
    Location:12525
    2A0119; cation transport protein
  2. NM_013667.3NP_038695.1  solute carrier family 22 member 2 isoform 1

    See identical proteins and their annotated locations for NP_038695.1

    Status: VALIDATED

    Source sequence(s)
    AC167817, AK052658, AK143892, BB739804
    Consensus CDS
    CCDS28392.1
    UniProtKB/Swiss-Prot
    O70577, Q8BWF6, Q8K4X8
    Related
    ENSMUSP00000041186.8, ENSMUST00000046959.9
    Conserved Domains (2) summary
    cd06174
    Location:125492
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:12525
    2A0119; cation transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    12803076..12847376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)