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Slc22a1 solute carrier family 22 (organic cation transporter), member 1 [ Mus musculus (house mouse) ]

Gene ID: 20517, updated on 9-May-2024

Summary

Official Symbol
Slc22a1provided by MGI
Official Full Name
solute carrier family 22 (organic cation transporter), member 1provided by MGI
Primary source
MGI:MGI:108111
See related
Ensembl:ENSMUSG00000023829 AllianceGenome:MGI:108111
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lx1; Oct1; Orct; Orct1
Summary
Enables several functions, including pyrimidine nucleoside transmembrane transporter activity; toxin transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in toxin transport and xenobiotic transport. Acts upstream of or within cation transport. Located in apical plasma membrane. Is expressed in several structures, including adrenal gland; liver; mammary gland; metanephros; and nasal cavity mucosa. Orthologous to human SLC22A1 (solute carrier family 22 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 210.5), kidney adult (RPKM 182.5) and 4 other tissues See more
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Genomic context

See Slc22a1 in Genome Data Viewer
Location:
17 A1; 17 8.63 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (12867761..12894725, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (12648874..12675838, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 (organic cation transporter), member 3 Neighboring gene RIKEN cDNA C030013G03 gene Neighboring gene solute carrier family 22 (organic cation transporter), member 2 Neighboring gene STARR-seq mESC enhancer starr_41857 Neighboring gene insulin-like growth factor 2 receptor Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:12938713-12938996 Neighboring gene antisense Igf2r RNA Neighboring gene VISTA enhancer mm89 Neighboring gene predicted gene, 49958

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (4)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC14019

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables (R)-carnitine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables acetylcholine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables dopamine:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables monoamine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables monoamine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables neurotransmitter transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables neurotransmitter transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables norepinephrine:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
 
enables organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables organic cation transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables organic cation transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables organic cation transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables prostaglandin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables putrescine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables pyrimidine nucleoside transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables pyrimidine nucleoside transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables quaternary ammonium group transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables quaternary ammonium group transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables secondary active organic cation transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables spermidine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables thiamine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables toxin transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables toxin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables xenobiotic transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables xenobiotic transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables xenobiotic transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in (R)-carnitine transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in acetylcholine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in acyl carnitine transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular detoxification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular detoxification ISO
Inferred from Sequence Orthology
more info
 
involved_in dopamine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dopamine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in dopamine uptake ISO
Inferred from Sequence Orthology
more info
 
involved_in epinephrine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epinephrine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment or maintenance of transmembrane electrochemical gradient ISO
Inferred from Sequence Orthology
more info
 
involved_in monoamine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in monoamine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in monoatomic cation transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic cation transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in neurotransmitter transport ISO
Inferred from Sequence Orthology
more info
 
involved_in norepinephrine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in norepinephrine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in organic cation transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in organic cation transport ISO
Inferred from Sequence Orthology
more info
 
involved_in prostaglandin transport ISO
Inferred from Sequence Orthology
more info
 
involved_in putrescine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in quaternary ammonium group transport ISO
Inferred from Sequence Orthology
more info
 
involved_in serotonin transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in serotonin transport ISO
Inferred from Sequence Orthology
more info
 
involved_in serotonin uptake ISO
Inferred from Sequence Orthology
more info
 
involved_in spermidine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in thiamine transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in thiamine transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in thiamine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in xenobiotic transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in xenobiotic transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in xenobiotic transport ISO
Inferred from Sequence Orthology
more info
 
involved_in xenobiotic transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
solute carrier family 22 member 1
Names
mOCT1
organic cation transporter 1
solute carrier family 22, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009202.5NP_033228.2  solute carrier family 22 member 1

    See identical proteins and their annotated locations for NP_033228.2

    Status: PROVISIONAL

    Source sequence(s)
    AC167817
    Consensus CDS
    CCDS28393.1
    UniProtKB/Swiss-Prot
    O08966, Q9R1Q4
    Related
    ENSMUSP00000024596.9, ENSMUST00000024596.10
    Conserved Domains (2) summary
    cd06174
    Location:125515
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:12525
    2A0119; cation transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    12867761..12894725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)