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Slc20a2 solute carrier family 20, member 2 [ Mus musculus (house mouse) ]

Gene ID: 20516, updated on 26-Jun-2024

Summary

Official Symbol
Slc20a2provided by MGI
Official Full Name
solute carrier family 20, member 2provided by MGI
Primary source
MGI:MGI:97851
See related
Ensembl:ENSMUSG00000037656 AllianceGenome:MGI:97851
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pit2; Ram1; Pit-2; Ram-1; MolPit2
Summary
Predicted to enable inorganic phosphate transmembrane transporter activity. Predicted to be involved in phosphate ion transmembrane transport. Predicted to act upstream of or within phosphate ion transport; sodium ion transport; and viral process. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; liver; male reproductive gland or organ; spleen; and yolk sac. Used to study basal ganglia calcification. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human SLC20A2 (solute carrier family 20 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 44.7), cerebellum adult (RPKM 21.7) and 28 other tissues See more
Orthologs
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Genomic context

See Slc20a2 in Genome Data Viewer
Location:
8 A2; 8 11.42 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (22966771..23059632)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22476700..22569616)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20903 Neighboring gene mitochondrial ribosomal protein S31 Neighboring gene STARR-seq mESC enhancer starr_20904 Neighboring gene predicted gene, 39140 Neighboring gene STARR-positive B cell enhancer ABC_E9722 Neighboring gene small integral membrane protein 19 Neighboring gene STARR-seq mESC enhancer starr_20908 Neighboring gene voltage-dependent anion channel 3 Neighboring gene predicted gene, 30086

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sodium:phosphate symporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sodium:phosphate symporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables sodium:phosphate symporter activity ISO
Inferred from Sequence Orthology
more info
 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
enables virus receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphate ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphate ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphate ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sodium-dependent phosphate transporter 2
Names
phosphate transporter 2
type III sodium-dependent phosphate transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424901.1NP_001411830.1  sodium-dependent phosphate transporter 2

    Status: VALIDATED

    Source sequence(s)
    AC140326, AC153017
    UniProtKB/Swiss-Prot
    E9QLQ8, Q3TBZ8, Q80UP8, Q9ES96
  2. NM_001424902.1NP_001411831.1  sodium-dependent phosphate transporter 2

    Status: VALIDATED

    Source sequence(s)
    AC140326, AC153017
    UniProtKB/Swiss-Prot
    E9QLQ8, Q3TBZ8, Q80UP8, Q9ES96
  3. NM_001424903.1NP_001411832.1  sodium-dependent phosphate transporter 2

    Status: VALIDATED

    Source sequence(s)
    AC140326, AC153017
    UniProtKB/Swiss-Prot
    E9QLQ8, Q3TBZ8, Q80UP8, Q9ES96
  4. NM_011394.4NP_035524.2  sodium-dependent phosphate transporter 2

    See identical proteins and their annotated locations for NP_035524.2

    Status: VALIDATED

    Source sequence(s)
    AC140326, AC153017
    Consensus CDS
    CCDS22178.1
    UniProtKB/Swiss-Prot
    E9QLQ8, Q3TBZ8, Q80UP8, Q9ES96
    Related
    ENSMUSP00000065935.8, ENSMUST00000067786.9
    Conserved Domains (1) summary
    pfam01384
    Location:465638
    PHO4; Phosphate transporter family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    22966771..23059632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243367.2XP_030099227.1  sodium-dependent phosphate transporter 2 isoform X2

    Conserved Domains (1) summary
    pfam01384
    Location:288461
    PHO4; Phosphate transporter family