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AMER3 APC membrane recruitment protein 3 [ Homo sapiens (human) ]

Gene ID: 205147, updated on 1-Jun-2020

Summary

Official Symbol
AMER3provided by HGNC
Official Full Name
APC membrane recruitment protein 3provided by HGNC
Primary source
HGNC:HGNC:26771
See related
Ensembl:ENSG00000178171
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM123C
Expression
Biased expression in brain (RPKM 2.4), stomach (RPKM 0.3) and 3 other tissues See more
Orthologs

Genomic context

See AMER3 in Genome Data Viewer
Location:
2q21.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (130754475..130768134)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (131513077..131525707)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene fatty acyl-CoA reductase 2 pseudogene 3 Neighboring gene Kruppel like factor 2 pseudogene 3 Neighboring gene G protein-coupled receptor 148 Neighboring gene CYCS pseudogene 8 Neighboring gene Rho guanine nucleotide exchange factor 4 Neighboring gene family with sequence similarity 168 member B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38377

Gene Ontology Provided by GOA

Function Evidence Code Pubs
beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
APC membrane recruitment protein 3
Names
family with sequence similarity 123C
protein FAM123C

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105193.2NP_001098663.1  APC membrane recruitment protein 3

    See identical proteins and their annotated locations for NP_001098663.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four transcript variants encode the same protein.
    Source sequence(s)
    AC140481, AK095696, BC113445, DA500900
    Consensus CDS
    CCDS2164.1
    UniProtKB/Swiss-Prot
    Q8N944
    Conserved Domains (2) summary
    PRK07764
    Location:510671
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam09422
    Location:237447
    WTX; WTX protein
  2. NM_001105194.1NP_001098664.1  APC membrane recruitment protein 3

    See identical proteins and their annotated locations for NP_001098664.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four transcript variants encode the same protein.
    Source sequence(s)
    AC140481, AK095696, BC113445, DA401709
    Consensus CDS
    CCDS2164.1
    UniProtKB/Swiss-Prot
    Q8N944
    Related
    ENSP00000392700.1, ENST00000423981.1
    Conserved Domains (2) summary
    PRK07764
    Location:510671
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam09422
    Location:237447
    WTX; WTX protein
  3. NM_001105195.2NP_001098665.1  APC membrane recruitment protein 3

    See identical proteins and their annotated locations for NP_001098665.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four transcript variants encode the same protein.
    Source sequence(s)
    AC140481, AK095696, BC113445, DA318919
    Consensus CDS
    CCDS2164.1
    UniProtKB/Swiss-Prot
    Q8N944
    Conserved Domains (2) summary
    PRK07764
    Location:510671
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam09422
    Location:237447
    WTX; WTX protein
  4. NM_152698.3NP_689911.2  APC membrane recruitment protein 3

    See identical proteins and their annotated locations for NP_689911.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AC140481, AK095696, BC113445, DA102742
    Consensus CDS
    CCDS2164.1
    UniProtKB/Swiss-Prot
    Q8N944
    Related
    ENSP00000314914.4, ENST00000321420.4
    Conserved Domains (2) summary
    PRK07764
    Location:510671
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam09422
    Location:237447
    WTX; WTX protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    130754475..130768134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510793.2XP_011509095.1  APC membrane recruitment protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011509095.1

    UniProtKB/Swiss-Prot
    Q8N944
    Conserved Domains (2) summary
    PRK07764
    Location:510671
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam09422
    Location:237447
    WTX; WTX protein
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