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Slc1a6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 [ Mus musculus (house mouse) ]

Gene ID: 20513, updated on 8-Dec-2022

Summary

Official Symbol
Slc1a6provided by MGI
Official Full Name
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6provided by MGI
Primary source
MGI:MGI:1096331
See related
Ensembl:ENSMUSG00000005357 AllianceGenome:MGI:1096331
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EAAT4
Summary
Enables L-glutamate transmembrane transporter activity. Acts upstream of or within L-glutamate transmembrane transport and regulation of membrane potential. Located in Golgi apparatus; glutamatergic synapse; and membrane. Is integral component of presynaptic membrane. Is expressed in central nervous system and retina. Orthologous to human SLC1A6 (solute carrier family 1 member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 37.6), CNS E18 (RPKM 8.8) and 5 other tissues See more
Orthologs
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Genomic context

See Slc1a6 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (78615923..78650659)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (78780086..78814825)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 105 Neighboring gene predicted gene, 30400 Neighboring gene predicted gene, 53211 Neighboring gene olfactory receptor family 7 subfamily C member 70 Neighboring gene olfactory receptor family 7 subfamily A member 39

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of membrane protein complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in parallel fiber to Purkinje cell synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
excitatory amino acid transporter 4
Names
high-affinity neuronal glutamate transporter
sodium-dependent glutamate/aspartate transporter
solute carrier family 1, member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009200.3NP_033226.1  excitatory amino acid transporter 4

    See identical proteins and their annotated locations for NP_033226.1

    Status: VALIDATED

    Source sequence(s)
    AK159197, BB668161, BB807884, BC138120
    Consensus CDS
    CCDS23970.1
    UniProtKB/Swiss-Prot
    O35544
    UniProtKB/TrEMBL
    B2RQX4, Q3TXM3
    Related
    ENSMUSP00000005490.9, ENSMUST00000005490.10
    Conserved Domains (1) summary
    pfam00375
    Location:55519
    SDF; Sodium:dicarboxylate symporter family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    78615923..78650659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513424.4XP_006513487.1  excitatory amino acid transporter 4 isoform X3

    Conserved Domains (1) summary
    pfam00375
    Location:55532
    SDF; Sodium:dicarboxylate symporter family
  2. XM_036155715.1XP_036011608.1  excitatory amino acid transporter 4 isoform X3

    Conserved Domains (1) summary
    pfam00375
    Location:55532
    SDF; Sodium:dicarboxylate symporter family
  3. XM_006513422.4XP_006513485.3  excitatory amino acid transporter 4 isoform X1

    Conserved Domains (1) summary
    pfam00375
    Location:83560
    SDF; Sodium:dicarboxylate symporter family
  4. XM_030244972.1XP_030100832.1  excitatory amino acid transporter 4 isoform X2

    Conserved Domains (1) summary
    pfam00375
    Location:83547
    SDF; Sodium:dicarboxylate symporter family