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Slc1a3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 [ Mus musculus (house mouse) ]

Gene ID: 20512, updated on 5-Apr-2024

Summary

Official Symbol
Slc1a3provided by MGI
Official Full Name
solute carrier family 1 (glial high affinity glutamate transporter), member 3provided by MGI
Primary source
MGI:MGI:99917
See related
Ensembl:ENSMUSG00000005360 AllianceGenome:MGI:99917
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gmt1; Eaat1; GLAST; GLU-T; GluT-1; MGluT1; GLAST-1; B430115D02Rik
Summary
Enables glutamate binding activity and high-affinity glutamate transmembrane transporter activity. Involved in D-aspartate import across plasma membrane and cellular response to cocaine. Acts upstream of or within several processes, including L-glutamate import across plasma membrane; gamma-aminobutyric acid biosynthetic process; and nervous system development. Located in several cellular components, including cell surface; neuron projection; and neuronal cell body. Is integral component of plasma membrane. Is expressed in several structures, including brain; connective tissue; eye; genitourinary system; and spinal cord. Used to study low tension glaucoma. Human ortholog(s) of this gene implicated in episodic ataxia type 6. Orthologous to human SLC1A3 (solute carrier family 1 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 107.1), cerebellum adult (RPKM 104.8) and 8 other tissues See more
Orthologs
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Genomic context

See Slc1a3 in Genome Data Viewer
Location:
15 A1; 15 3.82 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (8663608..8742648, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (8634124..8710807, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:8462039-8462148 Neighboring gene predicted gene, 49249 Neighboring gene STARR-seq mESC enhancer starr_37902 Neighboring gene STARR-seq mESC enhancer starr_37903 Neighboring gene STARR-seq mESC enhancer starr_37904 Neighboring gene STARR-seq mESC enhancer starr_37905 Neighboring gene STARR-seq mESC enhancer starr_37906 Neighboring gene predicted gene, 46508 Neighboring gene STARR-positive B cell enhancer ABC_E7359 Neighboring gene STARR-seq mESC enhancer starr_37907 Neighboring gene STARR-seq mESC enhancer starr_37908 Neighboring gene STARR-seq mESC enhancer starr_37909 Neighboring gene predicted gene, 57815 Neighboring gene STARR-seq mESC enhancer starr_37913 Neighboring gene STARR-seq mESC enhancer starr_37914 Neighboring gene predicted gene, 31340 Neighboring gene STARR-seq mESC enhancer starr_37917 Neighboring gene STARR-seq mESC enhancer starr_37918 Neighboring gene myotubularin related protein 3 pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in D-aspartate import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in D-aspartate import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in D-aspartate import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in L-aspartate import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in L-aspartate import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within L-glutamate import IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in L-glutamate import ISO
Inferred from Sequence Orthology
more info
 
involved_in L-glutamate import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within L-glutamate import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in L-glutamate import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within L-glutamate transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within L-glutamate transmembrane transport ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in L-glutamate transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within amino acid transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within auditory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell morphogenesis involved in neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to cocaine IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chloride transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cranial nerve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gamma-aminobutyric acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular sodium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in malate-aspartate shuttle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuromuscular process controlling balance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to amino acid ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within response to antibiotic IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to inorganic substance ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within response to light stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to wounding IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of membrane protein complex ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
excitatory amino acid transporter 1
Names
glial high affinity glutamate transporter
glutamate/aspartate transporter
high-affinity neuronal glutamate transporter
sodium-dependent glutamate/aspartate transporter 1
solute carrier family 1, member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_148938.3NP_683740.1  excitatory amino acid transporter 1

    See identical proteins and their annotated locations for NP_683740.1

    Status: VALIDATED

    Source sequence(s)
    AK031831, AK040798, BC058711, BY281420
    Consensus CDS
    CCDS27373.1
    UniProtKB/Swiss-Prot
    P56564, Q99P53
    UniProtKB/TrEMBL
    Q543U3, Q8C3T7, Q8C7W8
    Related
    ENSMUSP00000005493.8, ENSMUST00000005493.14
    Conserved Domains (1) summary
    pfam00375
    Location:50497
    SDF; Sodium:dicarboxylate symporter family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    8663608..8742648 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159289.1XP_036015182.1  excitatory amino acid transporter 1 isoform X1

    UniProtKB/TrEMBL
    Q8C3T7, Q8C7W8
    Conserved Domains (1) summary
    pfam00375
    Location:5390
    SDF; Sodium:dicarboxylate symporter family