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Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 [ Mus musculus (house mouse) ]

Gene ID: 20511, updated on 5-Apr-2024

Summary

Official Symbol
Slc1a2provided by MGI
Official Full Name
solute carrier family 1 (glial high affinity glutamate transporter), member 2provided by MGI
Primary source
MGI:MGI:101931
See related
Ensembl:ENSMUSG00000005089 AllianceGenome:MGI:101931
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GLT1; Eaat2; GLT-1; MGLT1; 1700091C19Rik; 2900019G14Rik
Summary
Enables cysteine transmembrane transporter activity and high-affinity glutamate transmembrane transporter activity. Involved in several processes, including L-glutamate import across plasma membrane; cellular response to cocaine; and glutathione biosynthetic process. Acts upstream of or within several processes, including L-glutamate transmembrane transport; positive regulation of glucose import; and visual behavior. Located in several cellular components, including astrocyte projection; axolemma; and membrane raft. Is integral component of plasma membrane. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and spinal cord. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 41. Orthologous to human SLC1A2 (solute carrier family 1 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 172.0), frontal lobe adult (RPKM 137.5) and 2 other tissues See more
Orthologs
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Genomic context

See Slc1a2 in Genome Data Viewer
Location:
2 E2; 2 54.13 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (102488584..102621129)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (102658239..102790784)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene four jointed box 1 Neighboring gene STARR-seq mESC enhancer starr_05255 Neighboring gene STARR-seq mESC enhancer starr_05256 Neighboring gene peptidase domain containing associated with muscle regeneration 1 Neighboring gene STARR-seq mESC enhancer starr_05257 Neighboring gene STARR-seq mESC enhancer starr_05258 Neighboring gene predicted gene, 57687 Neighboring gene STARR-positive B cell enhancer ABC_E2631 Neighboring gene predicted gene 13872 Neighboring gene STARR-positive B cell enhancer mm9_chr2:102635439-102635740 Neighboring gene STARR-seq mESC enhancer starr_05259 Neighboring gene CD44 antigen Neighboring gene STARR-positive B cell enhancer ABC_E5950 Neighboring gene STARR-positive B cell enhancer ABC_E3387 Neighboring gene STARR-seq mESC enhancer starr_05260 Neighboring gene STARR-seq mESC enhancer starr_05261 Neighboring gene STARR-seq mESC enhancer starr_05262 Neighboring gene predicted gene, 23731 Neighboring gene STARR-positive B cell enhancer ABC_E9522 Neighboring gene STARR-positive B cell enhancer ABC_E2632 Neighboring gene predicted gene, 34483

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in D-aspartate import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in L-aspartate import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in L-aspartate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in L-glutamate import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in L-glutamate import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within L-glutamate import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in L-glutamate import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within L-glutamate transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within L-glutamate transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in L-glutamate transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adult behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within amino acid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to cocaine IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to extracellular stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glutathione biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within monoatomic anion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neurotransmitter reuptake IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein homotrimerization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to amino acid IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to light stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to wounding IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within telencephalon development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within visual behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in astrocyte projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in astrocyte projection ISO
Inferred from Sequence Orthology
more info
 
located_in axolemma IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of membrane protein complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft IGI
Inferred from Genetic Interaction
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection terminus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IC
Inferred by Curator
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
excitatory amino acid transporter 2
Names
EAAT2 variant mEAAT2/5UT2
EAAT2 variant mEAAT2/5UT5
glutamate transporter 1c
sodium-dependent glutamate/aspartate transporter 2
solute carrier family 1, member 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077514.4NP_001070982.1  excitatory amino acid transporter 2 isoform 1

    See identical proteins and their annotated locations for NP_001070982.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK134609, AL844155
    Consensus CDS
    CCDS38188.1
    UniProtKB/Swiss-Prot
    O35877, O54686, O54687, P43006
    UniProtKB/TrEMBL
    Q3USU5, Q3UYK6
    Related
    ENSMUSP00000079100.4, ENSMUST00000080210.10
    Conserved Domains (1) summary
    pfam00375
    Location:46495
    SDF; Sodium:dicarboxylate symporter family
  2. NM_001077515.2NP_001070983.1  excitatory amino acid transporter 2 isoform 2

    See identical proteins and their annotated locations for NP_001070983.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK134609, AL844155, AL844605
    Consensus CDS
    CCDS38189.1
    UniProtKB/TrEMBL
    A2APL8, Q3USU5
    Related
    ENSMUSP00000106843.2, ENSMUST00000111212.8
    Conserved Domains (1) summary
    pfam00375
    Location:43492
    SDF; Sodium:dicarboxylate symporter family
  3. NM_001361018.1NP_001347947.1  excitatory amino acid transporter 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL844155, AL844605
    Consensus CDS
    CCDS89527.1
    UniProtKB/TrEMBL
    A2APL5, X2D841
    Related
    ENSMUSP00000106844.2, ENSMUST00000111213.8
    Conserved Domains (1) summary
    pfam00375
    Location:46495
    SDF; Sodium:dicarboxylate symporter family
  4. NM_011393.2NP_035523.1  excitatory amino acid transporter 2 isoform 3

    See identical proteins and their annotated locations for NP_035523.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' ends (UTR and coding sequence) compared to variant 1. The resulting isoform (3) has shorter and distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AL844155, AL844605
    Consensus CDS
    CCDS16469.1
    UniProtKB/TrEMBL
    A2APL7, X2D841
    Related
    ENSMUSP00000005220.5, ENSMUST00000005220.11
    Conserved Domains (1) summary
    pfam00375
    Location:43492
    SDF; Sodium:dicarboxylate symporter family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    102488584..102621129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248894.1XP_030104754.1  excitatory amino acid transporter 2 isoform X1

    UniProtKB/TrEMBL
    Q3USU5
    Conserved Domains (1) summary
    pfam00375
    Location:37486
    SDF; Sodium:dicarboxylate symporter family
  2. XM_006499047.4XP_006499110.1  excitatory amino acid transporter 2 isoform X2

    UniProtKB/TrEMBL
    X2D841
    Conserved Domains (1) summary
    pfam00375
    Location:46495
    SDF; Sodium:dicarboxylate symporter family
  3. XM_011239398.4XP_011237700.1  excitatory amino acid transporter 2 isoform X1

    UniProtKB/TrEMBL
    Q3USU5
    Conserved Domains (1) summary
    pfam00375
    Location:37486
    SDF; Sodium:dicarboxylate symporter family
  4. XM_030248893.1XP_030104753.1  excitatory amino acid transporter 2 isoform X1

    UniProtKB/TrEMBL
    Q3USU5
    Conserved Domains (1) summary
    pfam00375
    Location:37486
    SDF; Sodium:dicarboxylate symporter family