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Slc18a3 solute carrier family 18 (vesicular monoamine), member 3 [ Mus musculus (house mouse) ]

Gene ID: 20508, updated on 11-Jun-2024

Summary

Official Symbol
Slc18a3provided by MGI
Official Full Name
solute carrier family 18 (vesicular monoamine), member 3provided by MGI
Primary source
MGI:MGI:1101061
See related
Ensembl:ENSMUSG00000100241 AllianceGenome:MGI:1101061
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
VAT; VAChT
Summary
Predicted to enable acetylcholine transmembrane transporter activity. Involved in neurotransmitter loading into synaptic vesicle. Located in cytoplasm and terminal bouton. Is active in cholinergic synapse. Is expressed in several structures, including esophagus; heart; nervous system; pelvic ganglion; and sensory organ. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 21. Orthologous to human SLC18A3 (solute carrier family 18 member A3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Slc18a3 in Genome Data Viewer
Location:
14 B; 14 19.4 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (32184394..32186807, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (32462437..32464850, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene oxoglutarate dehydrogenase-like Neighboring gene predicted gene, 52134 Neighboring gene RIKEN cDNA 1700024G13 gene Neighboring gene STARR-seq mESC enhancer starr_36344 Neighboring gene choline O-acetyltransferase Neighboring gene excision repair cross-complementing rodent repair deficiency, complementation group 6 Neighboring gene dorsal root ganglia homeobox

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylcholine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables acetylcholine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables acetylcholine:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
 
enables monoamine transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
enables monoamine:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of AP-1 adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of AP-1 adaptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of AP-2 adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of AP-2 adaptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
is_active_in cholinergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in cholinergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cholinergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in terminal bouton IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
vesicular acetylcholine transporter
Names
solute carrier family 18 member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021712.3NP_068358.2  vesicular acetylcholine transporter

    See identical proteins and their annotated locations for NP_068358.2

    Status: VALIDATED

    Source sequence(s)
    AC167565
    Consensus CDS
    CCDS79291.1
    UniProtKB/Swiss-Prot
    O35304
    UniProtKB/TrEMBL
    Q3TYJ1
    Related
    ENSMUSP00000139829.2, ENSMUST00000191501.2
    Conserved Domains (2) summary
    TIGR00880
    Location:125260
    2_A_01_02; Multidrug resistance protein
    pfam07690
    Location:124436
    MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    32184394..32186807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)