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Slc12a7 solute carrier family 12, member 7 [ Mus musculus (house mouse) ]

Gene ID: 20499, updated on 22-May-2022

Summary

Official Symbol
Slc12a7provided by MGI
Official Full Name
solute carrier family 12, member 7provided by MGI
Primary source
MGI:MGI:1342283
See related
Ensembl:ENSMUSG00000017756 AllianceGenome:MGI:1342283
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kcc4; AA408796; D13Ertd261e
Summary
Enables ammonium transmembrane transporter activity and cation:chloride symporter activity. Involved in ammonium import across plasma membrane. Acts upstream of or within chloride transmembrane transport. Located in plasma membrane. Is expressed in vestibulo-cochlear ganglion. Orthologous to human SLC12A7 (solute carrier family 12 member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 62.1), heart adult (RPKM 48.1) and 24 other tissues See more
Orthologs
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Genomic context

See Slc12a7 in Genome Data Viewer
Location:
13 C1; 13 40.15 cM
Exon count:
30
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (73881172..73964873)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (73733052..73816754)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (73901145..73954191)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 18 Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 19 Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 19, opposite strand Neighboring gene naked cuticle 2 Neighboring gene predicted pseudogene 8062 Neighboring gene predicted gene, 30303

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ammonium transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables potassium:chloride symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ammonium import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell volume homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell volume homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chloride ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
solute carrier family 12 member 7
Names
K-Cl cotransporter 4
electroneutral potassium-chloride cotransporter 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360694.1NP_001347623.1  solute carrier family 12 member 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT030152
    Conserved Domains (1) summary
    cl27256
    Location:451088
    SLC12; Solute carrier family 12
  2. NM_011390.2NP_035520.1  solute carrier family 12 member 7 isoform 1

    See identical proteins and their annotated locations for NP_035520.1

    Status: VALIDATED

    Source sequence(s)
    CT030152
    Consensus CDS
    CCDS26635.1
    UniProtKB/Swiss-Prot
    Q9WVL3
    UniProtKB/TrEMBL
    B9EIV8
    Related
    ENSMUSP00000017900.8, ENSMUST00000017900.9
    Conserved Domains (2) summary
    TIGR00930
    Location:451083
    2a30; K-Cl cotransporter
    pfam03522
    Location:7091083
    SLC12; Solute carrier family 12

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    73881172..73964873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517170.4XP_006517233.1  solute carrier family 12 member 7 isoform X1

    Conserved Domains (1) summary
    TIGR00930
    Location:741117
    2a30; K-Cl cotransporter
  2. XM_006517171.4XP_006517234.1  solute carrier family 12 member 7 isoform X2

    Conserved Domains (1) summary
    TIGR00930
    Location:741112
    2a30; K-Cl cotransporter
  3. XM_006517175.2XP_006517238.1  solute carrier family 12 member 7 isoform X5

    See identical proteins and their annotated locations for XP_006517238.1

    Conserved Domains (1) summary
    TIGR00930
    Location:11020
    2a30; K-Cl cotransporter
  4. XM_006517173.3XP_006517236.1  solute carrier family 12 member 7 isoform X3

    Conserved Domains (1) summary
    TIGR00930
    Location:201063
    2a30; K-Cl cotransporter
  5. XM_006517174.3XP_006517237.1  solute carrier family 12 member 7 isoform X4

    Conserved Domains (1) summary
    TIGR00930
    Location:121055
    2a30; K-Cl cotransporter