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Slc12a3 solute carrier family 12, member 3 [ Mus musculus (house mouse) ]

Gene ID: 20497, updated on 17-Jul-2018
Official Symbol
Slc12a3provided by MGI
Official Full Name
solute carrier family 12, member 3provided by MGI
Primary source
MGI:MGI:108114
See related
Ensembl:ENSMUSG00000031766 Vega:OTTMUSG00000061636
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NCC; TSC; NCCT; AI035291
Expression
Restricted expression toward kidney adult (RPKM 195.7) See more
Orthologs
See Slc12a3 in Genome Data Viewer
Location:
8 C5; 8 46.46 cM
Exon count:
26
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (94329109..94366222)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (96853108..96890122)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L10, pseudogene 5 Neighboring gene nucleoporin 93 Neighboring gene microRNA 138-2 Neighboring gene homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 Neighboring gene adaptor-related protein complex 3, sigma 1 subunit, pseudogene 2

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cation:chloride symporter activity IEA
Inferred from Electronic Annotation
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
potassium:chloride symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sodium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
sodium:chloride symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium:chloride symporter activity ISO
Inferred from Sequence Orthology
more info
 
sodium:potassium:chloride symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
symporter activity IEA
Inferred from Electronic Annotation
more info
 
transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell volume homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chloride ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chloride transport ISO
Inferred from Sequence Orthology
more info
 
ion transport IEA
Inferred from Electronic Annotation
more info
 
potassium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion import IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
sodium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
vesicle ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
solute carrier family 12 member 3
Names
Na-Cl symporter
thiazide-sensitive sodium-chloride cotransporter

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205311.1NP_001192240.1  solute carrier family 12 member 3 isoform 1

    See identical proteins and their annotated locations for NP_001192240.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC128663, AK052691
    Consensus CDS
    CCDS57632.1
    UniProtKB/Swiss-Prot
    P59158
    UniProtKB/TrEMBL
    Q543E4
    Related
    ENSMUSP00000034218.3, OTTMUSP00000077961, ENSMUST00000034218.4, OTTMUST00000150372
    Conserved Domains (3) summary
    TIGR00930
    Location:571001
    2a30; K-Cl cotransporter
    pfam03522
    Location:6531001
    SLC12; Solute carrier family 12
    pfam08403
    Location:43113
    AA_permease_N; Amino acid permease N-terminal
  2. NM_019415.2NP_062288.2  solute carrier family 12 member 3 isoform 2

    See identical proteins and their annotated locations for NP_062288.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AI647800, AI882166, AK052691
    UniProtKB/TrEMBL
    Q543E4
    Conserved Domains (3) summary
    TIGR00930
    Location:571000
    2a30; K-Cl cotransporter
    pfam03522
    Location:6521000
    SLC12; Solute carrier family 12
    pfam08403
    Location:43112
    AA_permease_N; Amino acid permease N-terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

    Range
    94329109..94366222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312625.1XP_017168114.1  solute carrier family 12 member 3 isoform X1

  2. XM_017312626.1XP_017168115.1  solute carrier family 12 member 3 isoform X2

  3. XM_017312627.1XP_017168116.1  solute carrier family 12 member 3 isoform X3

RNA

  1. XR_001778414.1 RNA Sequence

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