U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Slc12a2 solute carrier family 12, member 2 [ Mus musculus (house mouse) ]

Gene ID: 20496, updated on 1-Mar-2024

Summary

Official Symbol
Slc12a2provided by MGI
Official Full Name
solute carrier family 12, member 2provided by MGI
Primary source
MGI:MGI:101924
See related
Ensembl:ENSMUSG00000024597 AllianceGenome:MGI:101924
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nkcc1; mBSC2; sy-ns; 9330166H04Rik
Summary
Enables potassium ion transmembrane transporter activity. Involved in several processes, including T cell chemotaxis; cellular response to potassium ion; and inorganic ion transmembrane transport. Acts upstream of or within several processes, including cellular ion homeostasis; mammary gland duct morphogenesis; and regulation of secretion by cell. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; lung; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 78 and middle cerebral artery infarction. Orthologous to human SLC12A2 (solute carrier family 12 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in mammary gland adult (RPKM 43.3), colon adult (RPKM 19.3) and 20 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Slc12a2 in Genome Data Viewer
Location:
18 D3; 18 32.15 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (58011505..58079893)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (57878512..57946821)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44692 Neighboring gene predicted gene, 19519 Neighboring gene predicted gene, 35751 Neighboring gene STARR-seq mESC enhancer starr_44694 Neighboring gene STARR-positive B cell enhancer mm9_chr18:58136200-58136501 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:58168874-58169112 Neighboring gene fibrillin 2 Neighboring gene STARR-seq mESC enhancer starr_44697 Neighboring gene STARR-seq mESC enhancer starr_44698 Neighboring gene predicted gene, 41741

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ammonium transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ammonium transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables chloride:monoatomic cation symporter activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables potassium ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables sodium:potassium:chloride symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sodium:potassium:chloride symporter activity IC
Inferred by Curator
more info
PubMed 
enables sodium:potassium:chloride symporter activity ISO
Inferred from Sequence Orthology
more info
 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in T cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in ammonium transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell volume homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell volume homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to chemokine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to chemokine ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to potassium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chloride ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chloride transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chloride transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in hyperosmotic response ISO
Inferred from Sequence Orthology
more info
 
involved_in inorganic anion import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inorganic cation import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within intracellular chloride ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular potassium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular sodium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within maintenance of blood-brain barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary duct terminal end bud growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of vascular wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of aspartate secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell volume ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of matrix metallopeptidase secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of spontaneous synaptic transmission IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of spontaneous synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of spontaneous synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sodium ion import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in transepithelial ammonium transport ISO
Inferred from Sequence Orthology
more info
 
involved_in transepithelial chloride transport ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
solute carrier family 12 member 2
Names
basolateral Na-K-Cl symporter
bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1
bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
sodium/potassium/chloride cotransporters
sodium/potassium/chloride transporters

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009194.3NP_033220.2  solute carrier family 12 member 2

    Status: VALIDATED

    Source sequence(s)
    AC127678, CJ172807, CN711123, U13174
    Consensus CDS
    CCDS37826.1
    UniProtKB/Swiss-Prot
    E9PYU3, P55012
    UniProtKB/TrEMBL
    E9QM38
    Related
    ENSMUSP00000111023.3, ENSMUST00000115366.3
    Conserved Domains (3) summary
    TIGR00930
    Location:2101206
    2a30; K-Cl cotransporter
    pfam03522
    Location:7951206
    SLC12; Solute carrier family 12
    pfam08403
    Location:196257
    AA_permease_N; Amino acid permease N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    58011505..58079893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525732.4XP_006525795.1  solute carrier family 12 member 2 isoform X1

    UniProtKB/Swiss-Prot
    E9PYU3, P55012
    Conserved Domains (2) summary
    PRK07764
    Location:374
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    TIGR00930
    Location:2101190
    2a30; K-Cl cotransporter

RNA

  1. XR_001782352.2 RNA Sequence