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Six2 sine oculis-related homeobox 2 [ Mus musculus (house mouse) ]

Gene ID: 20472, updated on 26-Nov-2016
Official Symbol
Six2provided by MGI
Official Full Name
sine oculis-related homeobox 2provided by MGI
Primary source
MGI:MGI:102778
See related
Ensembl:ENSMUSG00000024134 Vega:OTTMUSG00000040063
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Orthologs
Location:
17 E4; 17 55.72 cM
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (85662742..85688254, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (86083608..86087594, complement)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene developmentally regulated GTP binding protein 2 pseudogene Neighboring gene SIX homeobox 3, opposite strand 1 Neighboring gene sine oculis-related homeobox 3 Neighboring gene Riken cDNA CJ186046 gene Neighboring gene predicted gene, 41644

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
anterior/posterior axis specification IDA
Inferred from Direct Assay
more info
PubMed 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
condensed mesenchymal cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic cranial skeleton morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic skeletal system morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
kidney development ISO
Inferred from Sequence Orthology
more info
 
mesenchymal cell differentiation involved in kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesenchymal stem cell maintenance involved in nephron morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
mesenchymal stem cell maintenance involved in nephron morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesenchymal stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesenchymal to epithelial transition involved in metanephros morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
mesodermal cell fate specification IDA
Inferred from Direct Assay
more info
PubMed 
metanephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
middle ear morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
nephron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
nephron morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of chondrocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
regulation of branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
homeobox protein SIX2
Names
sine oculis homeobox homolog 2
sine oculis-related homeobox 2 homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011380.2NP_035510.1  homeobox protein SIX2

    See identical proteins and their annotated locations for NP_035510.1

    Status: VALIDATED

    Source sequence(s)
    AC166821, BC068021
    Consensus CDS
    CCDS29007.1
    UniProtKB/Swiss-Prot
    Q62232
    Related
    ENSMUSP00000125871, OTTMUSP00000058173, ENSMUST00000163568, OTTMUST00000104038
    Conserved Domains (2) summary
    cd00086
    Location:129180
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam16878
    Location:9118
    SIX1_SD; Transcriptional regulator, SIX1, N-terminal SD domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

    Range
    85662742..85688254 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246335.2XP_011244637.1  

    Conserved Domains (2) summary
    cd00086
    Location:129180
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam16878
    Location:9118
    SIX1_SD; Transcriptional regulator, SIX1, N-terminal SD domain
  2. XM_006523931.3XP_006523994.1  

    Conserved Domains (2) summary
    cd00086
    Location:129180
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam16878
    Location:9118
    SIX1_SD; Transcriptional regulator, SIX1, N-terminal SD domain
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