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Sin3b transcriptional regulator, SIN3B (yeast) [ Mus musculus (house mouse) ]

Gene ID: 20467, updated on 11-Apr-2024

Summary

Official Symbol
Sin3bprovided by MGI
Official Full Name
transcriptional regulator, SIN3B (yeast)provided by MGI
Primary source
MGI:MGI:107158
See related
Ensembl:ENSMUSG00000031622 AllianceGenome:MGI:107158
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810430C10Rik
Summary
Enables chromatin binding activity and transcription corepressor activity. Involved in cardiac muscle tissue development; negative regulation of transcription, DNA-templated; and skeletal muscle tissue development. Located in several cellular components, including autosome; nucleus; and sex chromosome. Is expressed in several structures, including central nervous system; dorsal root ganglion; eye; genitourinary system; and paraxial mesenchyme. Orthologous to human SIN3B (SIN3 transcription regulator family member B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 76.5), genital fat pad adult (RPKM 49.4) and 28 other tissues See more
Orthologs
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Genomic context

Location:
8 B3.3; 8 35.08 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (73449898..73484831)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (72723270..72758203)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51538 Neighboring gene NACHT and WD repeat domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E9732 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:75258942-75259146 Neighboring gene F2R like thrombin or trypsin receptor 3 Neighboring gene predicted gene, 39198

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of Sin3-type complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in X chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in XY body IDA
Inferred from Direct Assay
more info
PubMed 
located_in Y chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in autosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
paired amphipathic helix protein Sin3b
Names
SIN3 homolog B, transcription regulator
histone deacetylase complex subunit Sin3b
transcriptional corepressor Sin3b
transcriptional regulator, SIN3 yeast homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113248.2NP_001106719.1  paired amphipathic helix protein Sin3b isoform 2

    See identical proteins and their annotated locations for NP_001106719.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC171917, AK169433, BF318403
    Consensus CDS
    CCDS52598.1
    UniProtKB/TrEMBL
    Q3TN09
    Related
    ENSMUSP00000105576.4, ENSMUST00000109950.5
    Conserved Domains (1) summary
    pfam02671
    Location:5397
    PAH; Paired amphipathic helix repeat
  2. NM_009188.4NP_033214.2  paired amphipathic helix protein Sin3b isoform 1

    See identical proteins and their annotated locations for NP_033214.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (1).
    Source sequence(s)
    AC171917, AK169433
    Consensus CDS
    CCDS52599.1
    UniProtKB/Swiss-Prot
    O54976, Q62141, Q6A013, Q8VCB8, Q8VDZ5
    UniProtKB/TrEMBL
    Q3TXW9
    Related
    ENSMUSP00000004494.9, ENSMUST00000004494.16
    Conserved Domains (3) summary
    pfam02671
    Location:5397
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:386480
    Sin3_corepress; Sin3 family co-repressor
    pfam16879
    Location:7121011
    Sin3a_C; C-terminal domain of Sin3a protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    73449898..73484831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530789.2XP_006530852.1  paired amphipathic helix protein Sin3b isoform X1

    UniProtKB/TrEMBL
    Q3TXW9
    Conserved Domains (1) summary
    COG5602
    Location:401030
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]