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Sim1 single-minded family bHLH transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 20464, updated on 6-Jul-2021

Summary

Official Symbol
Sim1provided by MGI
Official Full Name
single-minded family bHLH transcription factor 1provided by MGI
Primary source
MGI:MGI:98306
See related
Ensembl:ENSMUSG00000019913
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mSIM1; bHLHe1; bHLHe14
Expression
Biased expression in kidney adult (RPKM 1.3), genital fat pad adult (RPKM 0.8) and 5 other tissues See more
Orthologs
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Genomic context

See Sim1 in Genome Data Viewer
Location:
10 B3; 10 24.87 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (50770794..50865252)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (50894698..50989156)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (50615457..50708958)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene activating signal cointegrator 1 complex subunit 3 Neighboring gene ribosomal protein L15 pseudogene Neighboring gene RIKEN cDNA A230054N11 gene Neighboring gene predicted gene, 35917 Neighboring gene predicted gene, 26257 Neighboring gene ribosomal protein L7A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Chemically induced (ENU) (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
single-minded homolog 1
Names
single-minded 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011376.3NP_035506.2  single-minded homolog 1

    See identical proteins and their annotated locations for NP_035506.2

    Status: VALIDATED

    Source sequence(s)
    AC152948, AC153951
    Consensus CDS
    CCDS48556.1
    UniProtKB/Swiss-Prot
    Q61045
    Related
    ENSMUSP00000020071.4, ENSMUST00000020071.4
    Conserved Domains (4) summary
    cd00130
    Location:88158
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam06621
    Location:360668
    SIM_C; Single-minded protein C-terminus
    pfam08447
    Location:243329
    PAS_3; PAS fold
    cd19738
    Location:171
    bHLH-PAS_SIM1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in single-minded homolog 1 (SIM1) and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    50770794..50865252
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512626.4XP_006512689.1  single-minded homolog 1 isoform X1

    Conserved Domains (4) summary
    cd00130
    Location:124194
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam06621
    Location:396704
    SIM_C; Single-minded protein C-terminus
    pfam08447
    Location:279365
    PAS_3; PAS fold
    cd19738
    Location:1107
    bHLH-PAS_SIM1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in single-minded homolog 1 (SIM1) and similar proteins
  2. XM_006512627.4XP_006512690.1  single-minded homolog 1 isoform X2

    See identical proteins and their annotated locations for XP_006512690.1

    UniProtKB/Swiss-Prot
    Q61045
    Conserved Domains (4) summary
    cd00130
    Location:88158
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam06621
    Location:360668
    SIM_C; Single-minded protein C-terminus
    pfam08447
    Location:243329
    PAS_3; PAS fold
    cd19738
    Location:171
    bHLH-PAS_SIM1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in single-minded homolog 1 (SIM1) and similar proteins
  3. XM_006512632.4XP_006512695.1  single-minded homolog 1 isoform X5

    See identical proteins and their annotated locations for XP_006512695.1

    Conserved Domains (3) summary
    cd00130
    Location:124194
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam08447
    Location:279365
    PAS_3; PAS fold
    cd19738
    Location:1107
    bHLH-PAS_SIM1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in single-minded homolog 1 (SIM1) and similar proteins
  4. XM_006512630.1XP_006512693.1  single-minded homolog 1 isoform X3

    Conserved Domains (2) summary
    pfam06621
    Location:225533
    SIM_C; Single-minded protein C-terminus
    pfam08447
    Location:108194
    PAS_3; PAS fold
  5. XM_006512631.1XP_006512694.1  single-minded homolog 1 isoform X4

    Conserved Domains (2) summary
    pfam06621
    Location:163471
    SIM_C; Single-minded protein C-terminus
    pfam08447
    Location:46132
    PAS_3; PAS fold
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