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St3gal1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 20442, updated on 8-Dec-2022

Summary

Official Symbol
St3gal1provided by MGI
Official Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 1provided by MGI
Primary source
MGI:MGI:98304
See related
Ensembl:ENSMUSG00000013846 AllianceGenome:MGI:98304
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Siat4; Siat4a; ST3GalI; St3gal-1; 5330418N22Rik
Summary
Enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. Involved in several processes, including ganglioside biosynthetic process via lactosylceramide; memory B cell differentiation; and negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process. Acts upstream of or within protein glycosylation and protein phosphorylation. Predicted to be located in Golgi medial cisterna membrane; Golgi trans cisterna membrane; and trans-Golgi network membrane. Is expressed in several structures, including alimentary system; ear; hemolymphoid system; integumental system; and nervous system. Orthologous to human ST3GAL1 (ST3 beta-galactoside alpha-2,3-sialyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in mammary gland adult (RPKM 22.6), liver adult (RPKM 19.4) and 27 other tissues See more
Orthologs
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Genomic context

See St3gal1 in Genome Data Viewer
Location:
15; 15 D2
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (66974724..67048795, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (67102875..67176946, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31286 Neighboring gene predicted gene, 31342 Neighboring gene RIKEN cDNA 1700012I11 gene Neighboring gene predicted gene, 31400 Neighboring gene predicted gene, 53906

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Clone Names

  • MGC90735

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi medial cisterna membrane ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi trans cisterna membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
Names
CMP-N-acetylneuraminate: [beta-galactosidase alpha-2,3] sialytransferase
Gal beta1,3 GalNAc alpha2,3 sialyltransferase
SIAT4-A
ST3GAL-I sialyltransferase
ST3Gal I
ST3GalA.1
ST3O
alpha 2,3-ST 1
beta-galactoside alpha-2,3-sialyltransferase 1
gal-NAc6S
gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase
monosialoganglioside sialyltransferase
sialyltransferase 4A (beta-galactosidase alpha-2,3-sialytransferase)
sialyltransferase 4A (beta-galactoside alpha-2,3-sialytransferase)
NP_033203.1
XP_006520727.1
XP_006520728.1
XP_011243831.1
XP_036015179.1
XP_036015180.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412635.1NP_001399564.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

    Status: VALIDATED

    Source sequence(s)
    AC087116, AC166984
    UniProtKB/Swiss-Prot
    Q11202
    UniProtKB/TrEMBL
    A0A8C6IAD5, Q544T4
  2. NM_001412636.1NP_001399565.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

    Status: VALIDATED

    Source sequence(s)
    AC087116, AC166984
    UniProtKB/Swiss-Prot
    Q11202
    UniProtKB/TrEMBL
    A0A8C6IAD5, Q544T4
  3. NM_001412637.1NP_001399566.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

    Status: VALIDATED

    Source sequence(s)
    AC087116, AC166984
    UniProtKB/Swiss-Prot
    Q11202
    UniProtKB/TrEMBL
    A0A8C6IAD5, Q544T4
  4. NM_009177.5NP_033203.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

    See identical proteins and their annotated locations for NP_033203.1

    Status: VALIDATED

    Source sequence(s)
    AC087116, AC166984
    Consensus CDS
    CCDS27511.1
    UniProtKB/Swiss-Prot
    P54751, Q11202
    UniProtKB/TrEMBL
    A0A8C6IAD5, Q544T4
    Related
    ENSMUSP00000154853.2, ENSMUST00000229028.2
    Conserved Domains (1) summary
    pfam00777
    Location:80335
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    66974724..67048795 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159286.1XP_036015179.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

    Conserved Domains (1) summary
    pfam00777
    Location:80335
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. XM_011245529.3XP_011243831.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    P54751
    UniProtKB/TrEMBL
    Q544T4
    Conserved Domains (1) summary
    pfam00777
    Location:80335
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  3. XM_006520665.5XP_006520728.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    P54751
    UniProtKB/TrEMBL
    Q544T4
    Related
    ENSMUSP00000155359.2, ENSMUST00000229213.2
    Conserved Domains (1) summary
    pfam00777
    Location:80335
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  4. XM_006520664.5XP_006520727.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006520727.1

    UniProtKB/Swiss-Prot
    P54751, Q11202
    UniProtKB/TrEMBL
    A0A8C6IAD5, Q544T4
    Related
    ENSMUSP00000090307.6, ENSMUST00000092640.6
    Conserved Domains (1) summary
    pfam00777
    Location:80335
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  5. XM_036159287.1XP_036015180.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q11202
    UniProtKB/TrEMBL
    A0A8C6IAD5, Q544T4
    Conserved Domains (1) summary
    pfam00777
    Location:80335
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033487.1: Suppressed sequence

    Description
    NM_001033487.1: This RefSeq was permanently suppressed because it was primarily intronic sequence.