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Shh sonic hedgehog [ Mus musculus (house mouse) ]

Gene ID: 20423, updated on 14-Sep-2021

Summary

Official Symbol
Shhprovided by MGI
Official Full Name
sonic hedgehogprovided by MGI
Primary source
MGI:MGI:98297
See related
Ensembl:ENSMUSG00000002633
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hx; Dsh; Hhg1; Hxl3; ShhNC; M100081; 9530036O11Rik
Expression
Biased expression in bladder adult (RPKM 27.9), adrenal adult (RPKM 21.2) and 9 other tissues See more
Orthologs
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Genomic context

See Shh in Genome Data Viewer
Location:
5 B1; 5 14.39 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (28661838..28672099, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (28456840..28467101, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (28783380..28793641, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35524 Neighboring gene predicted gene, 35602 Neighboring gene RNA binding motif protein 33 Neighboring gene RIKEN cDNA 9530036O11Rik Neighboring gene sonic hedgehog brain enhancer region in intron 2 Neighboring gene sonic hedgehog floor plate enhancer 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (21)  1 citation
  • Chemically induced (ENU) (7)  1 citation
  • Radiation induced (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables glycosaminoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables laminin-1 binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables patched binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables patched binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables patched binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Bergmann glial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in CD4-positive or CD8-positive, alpha-beta T cell lineage commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in CD4-positive or CD8-positive, alpha-beta T cell lineage commitment ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within anatomical structure development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within anatomical structure formation involved in morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within androgen metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within animal organ formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within artery development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within artery development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood coagulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching involved in blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching involved in prostate gland morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within branching involved in salivary gland morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within branching involved in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching morphogenesis of an epithelial tube IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within bud outgrowth involved in lung branching IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within camera-type eye development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within camera-type eye development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell fate specification IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell fate specification IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell proliferation in external granule layer IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell-cell signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to lithium ion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within central nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cerebellar granule cell precursor proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cerebellar granule cell precursor proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in commissural neuron axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in determination of left/right asymmetry in lateral mesoderm IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within developmental growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in digestive tract mesoderm development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dopaminergic neuron differentiation TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within dorsal/ventral neural tube patterning IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within dorsal/ventral neural tube patterning IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in dorsal/ventral neural tube patterning IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within ectoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryo development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryo development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic digestive tract morphogenesis TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within embryonic digit morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic digit morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic digit morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic foregut morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic forelimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic hindlimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic limb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic organ development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within epithelial cell proliferation involved in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epithelial-mesenchymal cell signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epithelial-mesenchymal signaling involved in prostate gland development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within epithelial-mesenchymal signaling involved in prostate gland development ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within establishment of cell polarity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within forebrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within forebrain regionalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within formation of anatomical boundary IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fungiform papilla development ISO
Inferred from Sequence Orthology
more info
 
involved_in fungiform papilla formation ISO
Inferred from Sequence Orthology
more info
 
involved_in fungiform papilla morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hair follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hair follicle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hindbrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hindbrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hindgut morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inner ear development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within inner ear development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intein-mediated protein splicing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within intermediate filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within left lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within limb bud formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within limb development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within limb development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung epithelium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung lobe morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung-associated mesenchyme development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lymphoid progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lymphoid progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within male genitalia development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male genitalia morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mesenchymal cell proliferation involved in lung development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within mesenchymal smoothened signaling pathway involved in prostate gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metanephric mesenchymal cell proliferation involved in metanephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metanephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within midbrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within myoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within myotube differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cholesterol efflux IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of dopaminergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of kidney smooth muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of mesenchymal cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription elongation from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of ureter smooth muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative thymic T cell selection IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neural tube formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neuron fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within odontogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within odontogenesis of dentin-containing tooth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within oligodendrocyte development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in oligodendrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within oligodendrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within osteoblast development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within pancreas development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pattern specification process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within pattern specification process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in polarity specification of anterior/posterior axis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell division ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cerebellar granule cell precursor proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of endothelial cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in prostate gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of hh target transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of hh target transcription factor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of hh target transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of hh target transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of immature T cell proliferation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of kidney smooth muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mesenchymal cell proliferation involved in ureter development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neurotrophin production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of oligodendrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of oligodendrocyte progenitor proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of penile erection ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of photoreceptor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein import into nucleus IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of sclerotome development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of skeletal muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of striated muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ureter smooth muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive thymic T cell selection IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within primary prostatic bud elongation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within prostate epithelial cord elongation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within prostate gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT acts_upstream_of_or_within prostatic bud formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein autoprocessing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein localization to nucleus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of epithelial cell proliferation involved in prostate gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within regulation of mesenchymal cell proliferation involved in prostate gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of odontogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of prostatic bud formation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of prostatic bud formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within respiratory tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to axon injury ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ethanol ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within right lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within roof of mouth development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within salivary gland cavitation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within signal transduction TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within skin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within smoothened signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in somite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spinal cord dorsal/ventral patterning IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spinal cord dorsal/ventral patterning ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spinal cord motor neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in stem cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within striated muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within striated muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within striated muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within telencephalon regionalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in telencephalon regionalization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within thalamus development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within thalamus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in thymus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within thyroid gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tongue development ISO
Inferred from Sequence Orthology
more info
 
involved_in tongue morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within trachea development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within trachea morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within tracheoesophageal septum formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within vasculogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vasculogenesis involved in coronary vascular morphogenesis TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within ventral spinal cord interneuron specification ISO
Inferred from Sequence Orthology
more info
 
involved_in zona limitans intrathalamica formation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in transport vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sonic hedgehog protein
Names
HHG-1
hemimelic extra toes
shh unprocessed N-terminal signaling and C-terminal autoprocessing domains
short digits

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009170.3NP_033196.1  sonic hedgehog protein precursor

    See identical proteins and their annotated locations for NP_033196.1

    Status: VALIDATED

    Source sequence(s)
    AK077688, BC063087
    Consensus CDS
    CCDS19146.1
    UniProtKB/Swiss-Prot
    Q62226
    Related
    ENSMUSP00000002708.4, ENSMUST00000002708.5
    Conserved Domains (3) summary
    cd00081
    Location:199349
    Hint; Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...
    pfam01079
    Location:188423
    Hint; Hint module
    pfam01085
    Location:40185
    HH_signal; Hedgehog amino-terminal signalling domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    28661838..28672099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535649.5XP_006535712.1  sonic hedgehog protein isoform X2

    Conserved Domains (2) summary
    pfam01079
    Location:74309
    Hint; Hint module
    pfam01085
    Location:171
    HH_signal; Hedgehog amino-terminal signalling domain
  2. XM_006535648.4XP_006535711.1  sonic hedgehog protein isoform X1

    Conserved Domains (2) summary
    pfam01079
    Location:97332
    Hint; Hint module
    pfam01085
    Location:1094
    HH_signal; Hedgehog amino-terminal signalling domain
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