U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ostf1 osteoclast stimulating factor 1 [ Mus musculus (house mouse) ]

Gene ID: 20409, updated on 26-Sep-2022

Summary

Official Symbol
Ostf1provided by MGI
Official Full Name
osteoclast stimulating factor 1provided by MGI
Primary source
MGI:MGI:700012
See related
Ensembl:ENSMUSG00000024725 AllianceGenome:MGI:700012
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SH3P2; Sh3d3
Summary
Enables SH3 domain binding activity. Predicted to be involved in signal transduction. Predicted to be located in cytoplasm. Is expressed in several structures, including cardiovascular system; central nervous system; peripheral nervous system ganglion; sensory organ; and urinary system. Orthologous to human OSTF1 (osteoclast stimulating factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 31.9), adrenal adult (RPKM 21.5) and 27 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Ostf1 in Genome Data Viewer
Location:
19 B; 19 13.17 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (18557728..18609177, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (18580364..18631813, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene thioredoxin domain containing 9 pseudogene Neighboring gene ribosomal protein L29, pseudogene 6 Neighboring gene nicotinamide riboside kinase 1 Neighboring gene carnosine N-methyltransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
osteoclast-stimulating factor 1
Names
SH3 domain protein 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017375.3NP_059071.1  osteoclast-stimulating factor 1

    See identical proteins and their annotated locations for NP_059071.1

    Status: VALIDATED

    Source sequence(s)
    AK002899, AK145949, BY065904
    Consensus CDS
    CCDS37930.1
    UniProtKB/Swiss-Prot
    Q3UF05, Q62422
    UniProtKB/TrEMBL
    A0A6P5NVL6, A0A8C6GV93
    Related
    ENSMUSP00000025631.7, ENSMUST00000025631.7
    Conserved Domains (3) summary
    cd11772
    Location:1668
    SH3_OSTF1; Src Homology 3 domain of metazoan osteoclast stimulating factor 1
    cd00204
    Location:75189
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:76103
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    18557728..18609177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)