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DMTN dematin actin binding protein [ Homo sapiens (human) ]

Gene ID: 2039, updated on 8-Jul-2021

Summary

Official Symbol
DMTNprovided by HGNC
Official Full Name
dematin actin binding proteinprovided by HGNC
Primary source
HGNC:HGNC:3382
See related
Ensembl:ENSG00000158856 MIM:125305
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DMT; EPB49
Summary
The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]
Expression
Broad expression in brain (RPKM 41.4), bone marrow (RPKM 23.9) and 18 other tissues See more
Orthologs
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Genomic context

See DMTN in Genome Data Viewer
Location:
8p21.3
Exon count:
21
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (22048931..22082525)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (21906442..21940036)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene nucleophosmin/nucleoplasmin 2 Neighboring gene VISTA enhancer hs782 Neighboring gene fibroblast growth factor 17 Neighboring gene VISTA enhancer hs781 Neighboring gene FHF complex subunit HOOK interacting protein 2B Neighboring gene nudix hydrolase 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ78462, FLJ98848

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein self-association IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables spectrin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in actin filament bundle assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in actin filament capping IEA
Inferred from Electronic Annotation
more info
 
involved_in actin filament reorganization ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT involved_in calcium-mediated signaling using extracellular calcium source ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in calcium-mediated signaling using extracellular calcium source ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in calcium-mediated signaling using intracellular calcium source ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
involved_in erythrocyte development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cell-substrate adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of focal adhesion assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of peptidyl-threonine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of peptidyl-tyrosine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein targeting to membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of substrate adhesion-dependent cell spreading ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of blood coagulation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of fibroblast migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of integrin-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of platelet aggregation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of substrate adhesion-dependent cell spreading ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of wound healing ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein secretion by platelet ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein-containing complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in actin cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
located_in actin filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cortical cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in platelet dense tubular network membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
located_in spectrin-associated cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dematin
Names
erythrocyte membrane protein band 4.9 (dematin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114135.5NP_001107607.1  dematin isoform 1

    See identical proteins and their annotated locations for NP_001107607.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, compared to variant 1. Variants 1-3 and 9-13 all encode the same isoform (1, also known as the 52 kDa subunit, PMID:7615546).
    Source sequence(s)
    BC006318, BC052805, BI222385, DA131656, DA267327
    Consensus CDS
    CCDS6020.1
    UniProtKB/Swiss-Prot
    Q08495
    Related
    ENSP00000265800.5, ENST00000265800.9
    Conserved Domains (2) summary
    smart00153
    Location:370405
    VHP; Villin headpiece domain
    pfam16182
    Location:8369
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  2. NM_001114136.3NP_001107608.1  dematin isoform 1

    See identical proteins and their annotated locations for NP_001107608.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 and 9-13 all encode the same isoform (1, also known as the 52 kDa subunit, PMID:7615546).
    Source sequence(s)
    AK289650, BC052805, BI222385, DA521027
    Consensus CDS
    CCDS6020.1
    UniProtKB/Swiss-Prot
    Q08495
    Related
    ENSP00000416111.1, ENST00000432128.5
    Conserved Domains (2) summary
    smart00153
    Location:370405
    VHP; Villin headpiece domain
    pfam16182
    Location:8369
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  3. NM_001114137.4NP_001107609.1  dematin isoform 2

    See identical proteins and their annotated locations for NP_001107609.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. Variants 4, 5, 7, 14, 15 and 16 encode the same isoform (2, also known as the 48 kDa subunit, PMID:7615546), which is shorter than isoform 1.
    Source sequence(s)
    AK055842, BC052805, BI222385, DA267327, DA634148
    Consensus CDS
    CCDS47820.1
    UniProtKB/Swiss-Prot
    Q08495
    Related
    ENSP00000370879.3, ENST00000381470.7
    Conserved Domains (2) summary
    smart00153
    Location:348383
    VHP; Villin headpiece domain
    pfam16182
    Location:8347
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  4. NM_001114138.3NP_001107610.1  dematin isoform 2

    See identical proteins and their annotated locations for NP_001107610.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate splice site 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. Variants 4, 5, 7, 14, 15 and 16 encode the same isoform (2, also known as the 48 kDa subunit, PMID:7615546), which is shorter than isoform 1.
    Source sequence(s)
    AC091171, AK055842, BC052805, BI222385, DA261872
    Consensus CDS
    CCDS47820.1
    UniProtKB/Swiss-Prot
    Q08495
    Related
    ENSP00000401291.1, ENST00000415253.5
    Conserved Domains (2) summary
    smart00153
    Location:348383
    VHP; Villin headpiece domain
    pfam16182
    Location:8347
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  5. NM_001114139.4NP_001107611.1  dematin isoform 3

    See identical proteins and their annotated locations for NP_001107611.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains an alternate exon in the 5' UTR and lacks alternate in-frame exons in the 5' and 3' coding regions, compared to variant 1. Variants 6 and 17 encode the same isoform (3), which is shorter than isoform 1.
    Source sequence(s)
    AK091581, BC052805, BI222385, DA267327
    Consensus CDS
    CCDS47821.1
    UniProtKB/Swiss-Prot
    Q08495
    Related
    ENSP00000397904.2, ENST00000443491.6
    Conserved Domains (2) summary
    smart00153
    Location:323358
    VHP; Villin headpiece domain
    pfam16182
    Location:7322
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  6. NM_001302816.3NP_001289745.1  dematin isoform 2

    See identical proteins and their annotated locations for NP_001289745.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. Variants 4, 5 and 7 encode the same isoform (2, also known as the 48 kDa subunit, PMID:7615546), which is shorter than isoform 1.
    Source sequence(s)
    AC091171, BC006318, BC052805, BI222385, DA170493, DA261872, DA267327, L19713
    Consensus CDS
    CCDS47820.1
    UniProtKB/Swiss-Prot
    Q08495
    Related
    ENSP00000429377.1, ENST00000519907.5
    Conserved Domains (2) summary
    smart00153
    Location:348383
    VHP; Villin headpiece domain
    pfam16182
    Location:8347
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  7. NM_001302817.3NP_001289746.1  dematin isoform 4

    See identical proteins and their annotated locations for NP_001289746.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1. Variants 8 and 18 encode the same isoform (4), which is shorter than isoform 1.
    Source sequence(s)
    AK295452, BC052805, BI222385, DA267327, DA521027
    Consensus CDS
    CCDS78311.1
    UniProtKB/Swiss-Prot
    Q08495
    Related
    ENSP00000430618.1, ENST00000517600.5
    Conserved Domains (2) summary
    smart00153
    Location:330365
    VHP; Villin headpiece domain
    pfam16182
    Location:7329
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  8. NM_001323378.2NP_001310307.1  dematin isoform 1

    Status: REVIEWED

    Source sequence(s)
    BC006318, BC052805, BI222385, DA170493, DA267327, DA521027
    Consensus CDS
    CCDS6020.1
    UniProtKB/Swiss-Prot
    Q08495
    Conserved Domains (2) summary
    smart00153
    Location:370405
    VHP; Villin headpiece domain
    pfam16182
    Location:8369
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  9. NM_001323379.2NP_001310308.1  dematin isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC091171, AK055842, AK289650, BC052805, BI222385, DA261872
    Consensus CDS
    CCDS6020.1
    UniProtKB/Swiss-Prot
    Q08495
    Conserved Domains (2) summary
    smart00153
    Location:370405
    VHP; Villin headpiece domain
    pfam16182
    Location:8369
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  10. NM_001323380.2NP_001310309.1  dematin isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC091171, AK055842, AK289650, BC052805, BI222385, BM547218
    Consensus CDS
    CCDS6020.1
    UniProtKB/Swiss-Prot
    Q08495
    Conserved Domains (2) summary
    smart00153
    Location:370405
    VHP; Villin headpiece domain
    pfam16182
    Location:8369
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  11. NM_001323381.2NP_001310310.1  dematin isoform 1

    Status: REVIEWED

    Source sequence(s)
    BC006318, BC052805, BI222385, DA141491, DA170493, DA267327, DA383880
    Consensus CDS
    CCDS6020.1
    UniProtKB/Swiss-Prot
    Q08495
    Conserved Domains (2) summary
    smart00153
    Location:370405
    VHP; Villin headpiece domain
    pfam16182
    Location:8369
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  12. NM_001323382.2NP_001310311.1  dematin isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC091171, AK289650, BC052805, BI222385, BI547589, HY024046
    Consensus CDS
    CCDS6020.1
    UniProtKB/Swiss-Prot
    Q08495
    Conserved Domains (2) summary
    smart00153
    Location:370405
    VHP; Villin headpiece domain
    pfam16182
    Location:8369
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  13. NM_001323383.2NP_001310312.1  dematin isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK055842, BC052805, BI222385, DA521027
    Consensus CDS
    CCDS47820.1
    UniProtKB/Swiss-Prot
    Q08495
    Conserved Domains (2) summary
    smart00153
    Location:348383
    VHP; Villin headpiece domain
    pfam16182
    Location:8347
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  14. NM_001323384.2NP_001310313.1  dematin isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK055842, BC052805, BI222385, DA267327, DA521027
    Consensus CDS
    CCDS47820.1
    UniProtKB/Swiss-Prot
    Q08495
    Conserved Domains (2) summary
    smart00153
    Location:348383
    VHP; Villin headpiece domain
    pfam16182
    Location:8347
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  15. NM_001323385.2NP_001310314.1  dematin isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK055842, AK295452, BC052805, BI222385, DA141491, DA267327, DA383880
    Consensus CDS
    CCDS47820.1
    UniProtKB/Swiss-Prot
    Q08495
    Conserved Domains (2) summary
    smart00153
    Location:348383
    VHP; Villin headpiece domain
    pfam16182
    Location:8347
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  16. NM_001323387.2NP_001310316.1  dematin isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC091171, AK091581, BC052805, BI222385, BM547218, DA267327
    Consensus CDS
    CCDS47821.1
    UniProtKB/Swiss-Prot
    Q08495
    Conserved Domains (2) summary
    smart00153
    Location:323358
    VHP; Villin headpiece domain
    pfam16182
    Location:7322
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  17. NM_001323388.2NP_001310317.1  dematin isoform 4

    Status: REVIEWED

    Source sequence(s)
    AK289650, AK295452, BC052805, BI222385, DA521027
    Consensus CDS
    CCDS78311.1
    UniProtKB/Swiss-Prot
    Q08495
    Conserved Domains (2) summary
    smart00153
    Location:330365
    VHP; Villin headpiece domain
    pfam16182
    Location:7329
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  18. NM_001323389.2NP_001310318.1  dematin isoform 5

    Status: REVIEWED

    Source sequence(s)
    BC006318, BC052805, BI222385, DA170493, DA267327, DA521027
    UniProtKB/Swiss-Prot
    Q08495
    Conserved Domains (2) summary
    smart00153
    Location:355390
    VHP; Villin headpiece domain
    pfam16182
    Location:8354
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  19. NM_001323390.2NP_001310319.1  dematin isoform 5

    Status: REVIEWED

    Source sequence(s)
    AK289650, BC006318, BC052805, BI222385, DA521027
    UniProtKB/Swiss-Prot
    Q08495
    Conserved Domains (2) summary
    smart00153
    Location:355390
    VHP; Villin headpiece domain
    pfam16182
    Location:8354
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  20. NM_001323391.2NP_001310320.1  dematin isoform 6

    Status: REVIEWED

    Source sequence(s)
    BC006318, BC052805, BI222385, DA131656, DA521027
    UniProtKB/Swiss-Prot
    Q08495
    Conserved Domains (2) summary
    smart00153
    Location:345380
    VHP; Villin headpiece domain
    pfam16182
    Location:7344
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  21. NM_001323392.2NP_001310321.1  dematin isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC091171, BC006318, BC052805, BI222385, DA131656, DA170493, DA261872
    UniProtKB/Swiss-Prot
    Q08495
    Conserved Domains (2) summary
    smart00153
    Location:345380
    VHP; Villin headpiece domain
    pfam16182
    Location:7344
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  22. NM_001323393.2NP_001310322.1  dematin isoform 6

    Status: REVIEWED

    Source sequence(s)
    AK289650, BC006318, BC052805, BI222385, DA131656, DA521027
    UniProtKB/Swiss-Prot
    Q08495
    Conserved Domains (2) summary
    smart00153
    Location:345380
    VHP; Villin headpiece domain
    pfam16182
    Location:7344
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  23. NM_001323394.2NP_001310323.1  dematin isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC091171, AK055842, AK289650, BC006318, BC052805, BI222385, DA131656, DA261872
    UniProtKB/Swiss-Prot
    Q08495
    Conserved Domains (2) summary
    smart00153
    Location:345380
    VHP; Villin headpiece domain
    pfam16182
    Location:7344
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  24. NM_001323395.2NP_001310324.1  dematin isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC091171, AK289650, BC006318, BC052805, BI222385, BM547218, DA131656
    UniProtKB/Swiss-Prot
    Q08495
    Conserved Domains (2) summary
    smart00153
    Location:345380
    VHP; Villin headpiece domain
    pfam16182
    Location:7344
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  25. NM_001323396.2NP_001310325.1  dematin isoform 6

    Status: REVIEWED

    Source sequence(s)
    BC006318, BC052805, BI222385, DA131656
    UniProtKB/Swiss-Prot
    Q08495
    Conserved Domains (2) summary
    smart00153
    Location:345380
    VHP; Villin headpiece domain
    pfam16182
    Location:7344
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  26. NM_001323397.2NP_001310326.1  dematin isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC091171, BC006318, BC052805, BI222385, BI547589, DA131656, HY024046
    UniProtKB/Swiss-Prot
    Q08495
    Conserved Domains (2) summary
    smart00153
    Location:345380
    VHP; Villin headpiece domain
    pfam16182
    Location:7344
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  27. NM_001323398.2NP_001310327.1  dematin isoform 7

    Status: REVIEWED

    Source sequence(s)
    AK295452, BC052805, BI222385, DA267327, DA521027
    UniProtKB/Swiss-Prot
    Q08495
    Conserved Domains (2) summary
    smart00153
    Location:308343
    VHP; Villin headpiece domain
    pfam16182
    Location:7307
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  28. NM_001323399.2NP_001310328.1  dematin isoform 7

    Status: REVIEWED

    Source sequence(s)
    AK295452, BC052805, BI222385, DA521027
    UniProtKB/Swiss-Prot
    Q08495
    Conserved Domains (2) summary
    smart00153
    Location:308343
    VHP; Villin headpiece domain
    pfam16182
    Location:7307
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  29. NM_001323400.2NP_001310329.1  dematin isoform 7

    Status: REVIEWED

    Source sequence(s)
    AK295452, BC052805, BI222385, DA141491, DA267327, DA383880
    UniProtKB/Swiss-Prot
    Q08495
    Conserved Domains (2) summary
    smart00153
    Location:308343
    VHP; Villin headpiece domain
    pfam16182
    Location:7307
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  30. NM_001323401.2NP_001310330.1  dematin isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC091171, AK295452, BC052805, BI222385, BM547218, DA267327
    UniProtKB/Swiss-Prot
    Q08495
    Conserved Domains (2) summary
    smart00153
    Location:308343
    VHP; Villin headpiece domain
    pfam16182
    Location:7307
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  31. NM_001387723.1NP_001374652.1  dematin isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC091171
    Conserved Domains (2) summary
    smart00153
    Location:345380
    VHP; Villin headpiece domain
    pfam16182
    Location:7344
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  32. NM_001387726.1NP_001374655.1  dematin isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC091171
    Conserved Domains (2) summary
    smart00153
    Location:348383
    VHP; Villin headpiece domain
    pfam16182
    Location:8347
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  33. NM_001387727.1NP_001374656.1  dematin isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC091171
    Conserved Domains (2) summary
    smart00153
    Location:370405
    VHP; Villin headpiece domain
    pfam16182
    Location:8369
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  34. NM_001387728.1NP_001374657.1  dematin isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC091171
    Conserved Domains (2) summary
    smart00153
    Location:348383
    VHP; Villin headpiece domain
    pfam16182
    Location:8347
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  35. NM_001387730.1NP_001374659.1  dematin isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC091171
    Conserved Domains (2) summary
    smart00153
    Location:370405
    VHP; Villin headpiece domain
    pfam16182
    Location:8369
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  36. NM_001387732.1NP_001374661.1  dematin isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC091171
    Conserved Domains (2) summary
    smart00153
    Location:370405
    VHP; Villin headpiece domain
    pfam16182
    Location:8369
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  37. NM_001387734.1NP_001374663.1  dematin isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC091171
    Conserved Domains (2) summary
    smart00153
    Location:348383
    VHP; Villin headpiece domain
    pfam16182
    Location:8347
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  38. NM_001387735.1NP_001374664.1  dematin isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC091171
    Conserved Domains (2) summary
    smart00153
    Location:370405
    VHP; Villin headpiece domain
    pfam16182
    Location:8369
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  39. NM_001387736.1NP_001374665.1  dematin isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC091171
    Related
    ENSP00000429234.2, ENST00000523782.6
    Conserved Domains (2) summary
    smart00153
    Location:323358
    VHP; Villin headpiece domain
    pfam16182
    Location:7322
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  40. NM_001387737.1NP_001374666.1  dematin isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC091171
    Conserved Domains (2) summary
    smart00153
    Location:333368
    VHP; Villin headpiece domain
    pfam16182
    Location:8332
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  41. NM_001387742.1NP_001374671.1  dematin isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC091171
    Conserved Domains (2) summary
    smart00153
    Location:348383
    VHP; Villin headpiece domain
    pfam16182
    Location:8347
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  42. NM_001387743.1NP_001374672.1  dematin isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC091171
    Conserved Domains (2) summary
    smart00153
    Location:355390
    VHP; Villin headpiece domain
    pfam16182
    Location:8354
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  43. NM_001387744.1NP_001374673.1  dematin isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC091171
    Conserved Domains (2) summary
    smart00153
    Location:330365
    VHP; Villin headpiece domain
    pfam16182
    Location:7329
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  44. NM_001387745.1NP_001374674.1  dematin isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC091171
    Conserved Domains (2) summary
    smart00153
    Location:333368
    VHP; Villin headpiece domain
    pfam16182
    Location:8332
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  45. NM_001387750.1NP_001374679.1  dematin isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC091171
    Conserved Domains (2) summary
    smart00153
    Location:370405
    VHP; Villin headpiece domain
    pfam16182
    Location:8369
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  46. NM_001387751.1NP_001374680.1  dematin isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC091171
    Conserved Domains (2) summary
    smart00153
    Location:370405
    VHP; Villin headpiece domain
    pfam16182
    Location:8369
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  47. NM_001387752.1NP_001374681.1  dematin isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC091171
    Conserved Domains (2) summary
    smart00153
    Location:323358
    VHP; Villin headpiece domain
    pfam16182
    Location:7322
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  48. NM_001387753.1NP_001374682.1  dematin isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC091171
    Conserved Domains (2) summary
    smart00153
    Location:370405
    VHP; Villin headpiece domain
    pfam16182
    Location:8369
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  49. NM_001387754.1NP_001374683.1  dematin isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC091171
    Conserved Domains (2) summary
    smart00153
    Location:330365
    VHP; Villin headpiece domain
    pfam16182
    Location:7329
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  50. NM_001387755.1NP_001374684.1  dematin isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC091171
    Conserved Domains (2) summary
    smart00153
    Location:348383
    VHP; Villin headpiece domain
    pfam16182
    Location:8347
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  51. NM_001387756.1NP_001374685.1  dematin isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC091171
    Conserved Domains (2) summary
    smart00153
    Location:323358
    VHP; Villin headpiece domain
    pfam16182
    Location:7322
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  52. NM_001387757.1NP_001374686.1  dematin isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC091171
    Conserved Domains (2) summary
    smart00153
    Location:323358
    VHP; Villin headpiece domain
    pfam16182
    Location:7322
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  53. NM_001978.5NP_001969.2  dematin isoform 1

    See identical proteins and their annotated locations for NP_001969.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1-3 and 9-13 all encode the same isoform (1, also known as the 52 kDa subunit, PMID:7615546).
    Source sequence(s)
    AC091171, BC006318, BC052805, BI222385, DA170493, DA261872, DA267327
    Consensus CDS
    CCDS6020.1
    UniProtKB/Swiss-Prot
    Q08495
    Related
    ENSP00000427866.1, ENST00000523266.5
    Conserved Domains (2) summary
    smart00153
    Location:370405
    VHP; Villin headpiece domain
    pfam16182
    Location:8369
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    22048931..22082525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013191.1XP_016868680.1  dematin isoform X3

    Conserved Domains (2) summary
    smart00153
    Location:333368
    VHP; Villin headpiece domain
    pfam16182
    Location:8332
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  2. XM_017013194.1XP_016868683.1  dematin isoform X4

    UniProtKB/Swiss-Prot
    Q08495
    Conserved Domains (2) summary
    smart00153
    Location:330365
    VHP; Villin headpiece domain
    pfam16182
    Location:7329
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  3. XM_017013198.1XP_016868687.1  dematin isoform X5

    UniProtKB/Swiss-Prot
    Q08495
    Conserved Domains (2) summary
    smart00153
    Location:323358
    VHP; Villin headpiece domain
    pfam16182
    Location:7322
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  4. XM_011544435.1XP_011542737.1  dematin isoform X1

    See identical proteins and their annotated locations for XP_011542737.1

    Conserved Domains (2) summary
    smart00153
    Location:355390
    VHP; Villin headpiece domain
    pfam16182
    Location:8354
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  5. XM_017013190.1XP_016868679.1  dematin isoform X3

    Conserved Domains (2) summary
    smart00153
    Location:333368
    VHP; Villin headpiece domain
    pfam16182
    Location:8332
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

RNA

  1. XR_002956616.1 RNA Sequence

  2. XR_002956605.1 RNA Sequence

  3. XR_002956611.1 RNA Sequence

  4. XR_002956619.1 RNA Sequence

  5. XR_002956614.1 RNA Sequence

  6. XR_002956612.1 RNA Sequence

  7. XR_002956617.1 RNA Sequence

  8. XR_002956610.1 RNA Sequence

  9. XR_002956606.1 RNA Sequence

  10. XR_002956615.1 RNA Sequence

  11. XR_002956608.1 RNA Sequence

  12. XR_002956613.1 RNA Sequence

  13. XR_002956604.1 RNA Sequence

  14. XR_002956609.1 RNA Sequence

  15. XR_002956607.1 RNA Sequence

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