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Sftpc surfactant associated protein C [ Mus musculus (house mouse) ]

Gene ID: 20389, updated on 31-Jan-2023

Summary

Official Symbol
Sftpcprovided by MGI
Official Full Name
surfactant associated protein Cprovided by MGI
Primary source
MGI:MGI:109517
See related
Ensembl:ENSMUSG00000022097 AllianceGenome:MGI:109517
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SP5; SPC; SP-C; Sftp2; Bricd6; Sftp-2; pro-SpC
Summary
Predicted to enable identical protein binding activity. Located in cytoplasm and extracellular region. Is expressed in several structures, including lung and main bronchus epithelium. Used to study desquamative interstitial pneumonia. Human ortholog(s) of this gene implicated in asthma; lung disease (multiple); and respiratory syncytial virus infectious disease. Orthologous to human SFTPC (surfactant protein C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward lung adult (RPKM 8709.5) See more
Orthologs
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Genomic context

See Sftpc in Genome Data Viewer
Location:
14 D2; 14 36.32 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70758381..70761521, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (70520941..70524081, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene phytanoyl-CoA hydroxylase interacting protein Neighboring gene bone morphogenetic protein 1 Neighboring gene predicted gene, 52136 Neighboring gene leucine-rich repeat LGI family, member 3 Neighboring gene receptor accessory protein 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (9)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in alveolar lamellar body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in alveolar lamellar body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in multivesicular body ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pulmonary surfactant-associated protein C
Names
pulmonary surfactant-associated proteolipid SPL(Val)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011359.2NP_035489.2  pulmonary surfactant-associated protein C

    See identical proteins and their annotated locations for NP_035489.2

    Status: VALIDATED

    Source sequence(s)
    AC122268, BY773034, CJ093163, CJ237354
    Consensus CDS
    CCDS27254.1
    UniProtKB/TrEMBL
    Q6P8P8
    Related
    ENSMUSP00000022692.4, ENSMUST00000022692.5
    Conserved Domains (3) summary
    smart00019
    Location:1193
    SF_P; Pulmonary surfactant proteins
    smart01039
    Location:94193
    BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer
    pfam08999
    Location:193
    SP_C-Propep; Surfactant protein C, N terminal propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    70758381..70761521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)